Abstract 5882: Prevention of antibiotic-induced dysbiosis in human volunteers by DAV132 and preservation of responsiveness to anti-PD-1 demonstrated by transplantation of human feces into tumor-bearing mice

Autor: Meriem Messaoudene, Nathalie Saint-Lu, Frédérique Sablier-Gallis, Stéphanie Ferreira, Mayra Ponce, Clément Le Bescop, Thomas Loppinet, Tanguy Corbel, Céline Féger, Fabien Vitry, Antoine Andremont, Jean de Gunzburg, Bertrand Routy

Publikováno v: Cancer Research. 83:5882-5882

Background: Over the last decade, studies unraveled the cancer-immune dialogue in the setting of immune checkpoint inhibitors (ICI) and influenced by the gut microbiota. The first evidence of the key role of the microbiota in ICI modulation was obser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c509cd056d94915319f78ee134e584ab
https://doi.org/10.1158/1538-7445.am2023-5882

DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

Autor: Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg

Publikováno v: Antimicrob Agents Chemother

Fluoroquinolone treatments induce dysbiosis of the intestinal microbiota, resulting in loss of resistance to colonization by exogenous bacteria such as Clostridioides difficile that may cause severe diarrhea in humans and lethal infection in hamsters

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a5f4e44c78ecca1119771ef74daba0
https://doi.org/10.1128/aac.01196-19

Impact of oral amoxicillin and amoxicillin/clavulanic acid treatment on bacterial diversity and β-lactam resistance in the canine faecal microbiota

Autor: Luca Guardabassi, Jean de Gunzburg, Teresa Pires dos Santos, Perrine Hugon, Agathe Nevière, Sakina Sayah-Jeanne, Frédérique Sablier-Gallis, Carmen Espinosa-Gongora, Lisbeth Rem Jessen, Charlotte R. Bjornvad, Peter Damborg, Dereje Dadi Gudeta, Nathalie Saint-Lu, Tanguy Corbel, Ida N. Kieler

Publikováno v: The Journal of antimicrobial chemotherapy. 75(2)

Background Aminopenicillins with or without a β-lactamase inhibitor are widely used in both human and veterinary medicine. However, little is known about their differential impact on the gut microbiota and development of antimicrobial resistance. Ob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2626323873d157c73a6957316d64a38
https://pubmed.ncbi.nlm.nih.gov/31778166

Protection of the Human Gut Microbiome From Antibiotics

Autor: Jean de Gunzburg, Violaine Augustin, Amine Ghozlane, Laurence Armand-Lefevre, Xavier Duval, Antoine Andremont, Frédérique Sablier-Gallis, Sean Kennedy, Annie Ducher, Marina Varastet, Loubna Alavoine, Nicolas Pons, Elisabeth Chachaty, Florence Levenez, Charles Burdet, Etienne Ruppé

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, 2018, 217 (4), pp.628-636. ⟨10.1093/infdis/jix604⟩
The Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2018, 217 (4), pp.628-636. ⟨10.1093/infdis/jix604⟩
Journal of Infectious Diseases 4 (217), 628-636. (2018)

In a phase 1 clinical study, coadministration of the adsorbent-based DAV132 product together with the fluoroquinolone antibiotic moxifloxacin, while not affecting the plasma concentrations of the antibiotic, reduced by >99% exposure of the intestinal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72129e0df637086bfb515cf4f8d8b31f
https://hal-pasteur.archives-ouvertes.fr/pasteur-02552147/document

Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics

Autor: Cornelis H. van Werkhoven, Annie Ducher, Matilda Berkell, Mohamed Mysara, Christine Lammens, Julian Torre-Cisneros, Jesús Rodríguez-Baño, Delia Herghea, Oliver A. Cornely, Lena M. Biehl, Louis Bernard, M. Angeles Dominguez-Luzon, Sofia Maraki, Olivier Barraud, Maria Nica, Nathalie Jazmati, Frederique Sablier-Gallis, Jean de Gunzburg, France Mentré, Surbhi Malhotra-Kumar, Marc J. M. Bonten, Maria J. G. T. Vehreschild, the ANTICIPATE Study Group

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Here, the authors report the incidence of Clostridioides difficile infection (CDI) and assess potential clinical characteristics and biomarkers to predict CDI in 1,007 patients of 50 years and above receiving newly initiated antibiotic treatment.

Externí odkaz: https://doaj.org/article/1522f4b91ec546008f82035912919766