Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring

Autor: Jean Nakhle, Khattar Khattar, Tülin Özkan, Adel Boughlita, Daouda Abba Moussa, Amelie Darlix, Frédérique Lorcy, Valérie RIGAU, Luc BAUCHET, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Floriant Bellvert, Laurent Turchi, Thierry Virolle, Jean-Philippe Hugnot, Nicolas Buisine, Mireille Galloni, Valerie Dardalhon, Anne-Marie Rodriguez, Marie-Luce Vignais

Publikováno v: Cancer Research Communications
Cancer Research Communications, 2023, 3 (6), pp.1041-1056. ⟨10.1158/2767-9764.CRC-23-0144⟩
Cancer Research Communications, 2023, 3, pp.1041-1056. ⟨10.1158/2767-9764.crc-23-0144⟩

International audience; Glioblastomas (GBM) are heterogeneous tumors with high metabolic plasticity. Their poor prognosis is linked to the presence of glioblastoma stem cells (GSC), which support resistance to therapy, notably to temozolomide (TMZ).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82ca59d992aa68ebf144b2b728720ed
https://hal.science/hal-04154698

Figure S6 from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring

Autor: Marie-Luce Vignais, Anne-Marie Rodriguez, Valerie Dardalhon, Mireille Galloni, Nicolas Buisine, Jean-Philippe Hugnot, Thierry Virolle, Laurent Turchi, Floriant Bellvert, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Luc BAUCHET, Valérie RIGAU, Frédérique Lorcy, Amelie Darlix, Daouda Abba Moussa, Adel Boughlita, Tülin Özkan, Khattar Khattar, Jean Nakhle

Metabolite detection in resected GBM from 8 patients, at 1rst resection and at 2nd resection post-TMZ treatment. For each metabolite, the C12/C13 ratios normalized to tissue protein concentrations are indicated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75e8ea53647e783fb37e804e586fbb0
https://doi.org/10.1158/2767-9764.23192206.v1

Figure S5 from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring

Autor: Marie-Luce Vignais, Anne-Marie Rodriguez, Valerie Dardalhon, Mireille Galloni, Nicolas Buisine, Jean-Philippe Hugnot, Thierry Virolle, Laurent Turchi, Floriant Bellvert, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Luc BAUCHET, Valérie RIGAU, Frédérique Lorcy, Amelie Darlix, Daouda Abba Moussa, Adel Boughlita, Tülin Özkan, Khattar Khattar, Jean Nakhle

MSC mitochondria modify the usage of metabolites by GCSs in response to TMZ CTRL Mito TMZ CTRL Mito Mito TMZ (A) Metabolic substrate consumption of GSCs expressed as metabolite initial consumption rates (Biolog MitoPlates). Mean values ± SEM (4 inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d45e77ebf4aefbeadb43ec8f0b76eb6
https://doi.org/10.1158/2767-9764.23192209.v1

Figure S1 from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring

Autor: Marie-Luce Vignais, Anne-Marie Rodriguez, Valerie Dardalhon, Mireille Galloni, Nicolas Buisine, Jean-Philippe Hugnot, Thierry Virolle, Laurent Turchi, Floriant Bellvert, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Luc BAUCHET, Valérie RIGAU, Frédérique Lorcy, Amelie Darlix, Daouda Abba Moussa, Adel Boughlita, Tülin Özkan, Khattar Khattar, Jean Nakhle

Experimental design and timeline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85887a1b5a0d3b796bd1583a5812c172
https://doi.org/10.1158/2767-9764.23192221.v1

Figure S4 from Mitochondria transfer from mesenchymal stem cells confers chemoresistance to Glioblastoma stem cells through metabolic rewiring

Autor: Marie-Luce Vignais, Anne-Marie Rodriguez, Valerie Dardalhon, Mireille Galloni, Nicolas Buisine, Jean-Philippe Hugnot, Thierry Virolle, Laurent Turchi, Floriant Bellvert, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin, Luc BAUCHET, Valérie RIGAU, Frédérique Lorcy, Amelie Darlix, Daouda Abba Moussa, Adel Boughlita, Tülin Özkan, Khattar Khattar, Jean Nakhle

Metabolites produced by GSCs following MSC mitochondria acquisition and TMZ treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7ba7e44421d63478dd434e23361de3
https://doi.org/10.1158/2767-9764.23192212