Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Frédérique Fenneteau"'
Publikováno v:
Chaos (Woodbury, N.Y.). 31(2)
Quantitative systems pharmacology (QSP) proved to be a powerful tool to elucidate the underlying pathophysiological complexity that is intensified by the biological variability and overlapped by the level of sophistication of drug dosing regimens. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0cd78907628f3becbda108994ca27b
https://pubmed.ncbi.nlm.nih.gov/33653032
https://pubmed.ncbi.nlm.nih.gov/33653032
Publikováno v:
Pharmacology & Pharmacy. :42-52
Noncompliance to therapeutic regimen is a real public health problem with tremendous socioeconomic consequences. Instead of direct intervention to patients, which can add extra burden to the already overloaded health system, alternative strategies or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20e317406ff209a505172096e8b1cb36
https://doi.org/10.4236/pp.2010.12007
https://doi.org/10.4236/pp.2010.12007
Publikováno v:
Journal of pharmaceutical sciences. 99(1)
The first objective of the present study was to predict the pharmacokinetics of selected CYP3A substrates administered at a single oral dose to human. The second objective was to predict pharmacokinetics of the selected drugs in presence of inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b452adaf2ddd37674231aaac61b7cea3
https://pubmed.ncbi.nlm.nih.gov/19479982
https://pubmed.ncbi.nlm.nih.gov/19479982
Autor:
Lucie Couture, Veronique Michaud, Frédérique Fenneteau, Jacques Turgeon, Fahima Nekka, Jun Li
Publikováno v:
Theoretical Biology and Medical Modelling, Vol 6, Iss 1, p 2 (2009)
Theoretical Biology & Medical Modelling
Theoretical Biology & Medical Modelling
Background The expression and activity of P-glycoproteins due to genetic or environmental factors may have a significant impact on drug disposition, drug effectiveness or drug toxicity. Hence, characterization of drug disposition over a wide range of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8662077a9043fdfa0d6487189c555e0f
http://www.tbiomed.com/content/6/1/2
http://www.tbiomed.com/content/6/1/2
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 36(6)
The structural complexity of a PBPK model is usually accompanied with significant uncertainty in estimating its input parameters. In the last decade, the global sensitivity analysis, which accounts for the variability of all model input parameters si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab122299329fc00da27b3d1a3914bb0
https://pubmed.ncbi.nlm.nih.gov/19847628
https://pubmed.ncbi.nlm.nih.gov/19847628
Publikováno v:
PAMM. 7:1121905-1121906
In order to improve understanding and prediction of drug disposition prior to in vivo experiments, we aimed to develop a PBPK model that accounts for the involvement of P-glycoprotein activity and expression in mouse brain, liver, kidney and heart ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41946fb754d6bb6e7e85d547733bda2e
https://doi.org/10.1002/pamm.200700608
https://doi.org/10.1002/pamm.200700608
Publikováno v:
Clinical Pharmacology & Therapeutics. 79:P49-P49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f667bbb47993aaf6c7e66b7e375542c6
https://doi.org/10.1016/j.clpt.2005.12.175
https://doi.org/10.1016/j.clpt.2005.12.175