Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Frédérick A, Mallette"'
Autor:
Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are characteristic of injured tissues and hence successive waves of inflammatory cells must be suit
Externí odkaz:
https://doaj.org/article/43e12a5532544c0686ece219c67a0571
Autor:
Haithem Barbour, Nadine Sen Nkwe, Benjamin Estavoyer, Clémence Messmer, Mila Gushul-Leclaire, Romain Villot, Maxime Uriarte, Karine Boulay, Sari Hlayhel, Bassel Farhat, Eric Milot, Frédérick A. Mallette, Salima Daou, El Bachir Affar
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106276- (2023)
Summary: Ubiquitination is an important post-translational modification (PTM) that regulates a large spectrum of cellular processes in eukaryotes. Abnormalities in ubiquitin signaling underlie numerous human pathologies including cancer and neurodege
Externí odkaz:
https://doaj.org/article/8268603610614df7a8f26515e242e596
Autor:
Maxime Uriarte, Nadine Sen Nkwe, Roch Tremblay, Oumaima Ahmed, Clémence Messmer, Nazar Mashtalir, Haithem Barbour, Louis Masclef, Marion Voide, Claire Viallard, Salima Daou, Djaileb Abdelhadi, Daryl Ronato, Mohammadjavad Paydar, Anaïs Darracq, Karine Boulay, Nicolas Desjardins-Lecavalier, Przemyslaw Sapieha, Jean-Yves Masson, Mikhail Sergeev, Benjamin H. Kwok, Laura Hulea, Frédérick A. Mallette, Eric Milot, Bruno Larrivée, Hugo Wurtele, El Bachir Affar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient reple
Externí odkaz:
https://doaj.org/article/b50e1f83646949fdb482fa1c4a35c9f5
Autor:
Jean-François Lemay, Edlie St-Hilaire, Daryl A Ronato, Yuandi Gao, François Bélanger, Sari Gezzar-Dandashi, Aimé Boris Kimenyi Ishimwe, Christina Sawchyn, Dominique Lévesque, Mary McQuaid, François-Michel Boisvert, Frédérick A Mallette, Jean-Yves Masson, Elliot A Drobetsky, Hugo Wurtele
Publikováno v:
PLoS Biology, Vol 20, Iss 10, p e3001543 (2022)
Helix-destabilizing DNA lesions induced by environmental mutagens such as UV light cause genomic instability by strongly blocking the progression of DNA replication forks (RFs). At blocked RF, single-stranded DNA (ssDNA) accumulates and is rapidly bo
Externí odkaz:
https://doaj.org/article/a406ab3b3aab4c1790f2cb75bdd9eeda
Autor:
Romain Villot, Audrey Poirier, Inan Bakan, Karine Boulay, Erlinda Fernández, Romain Devillers, Luciano Gama-Braga, Laura Tribouillard, Andréanne Gagné, Éma Duchesne, Danielle Caron, Jean-Sébastien Bérubé, Jean-Christophe Bérubé, Yan Coulombe, Michèle Orain, Yves Gélinas, Stéphane Gobeil, Yohan Bossé, Jean-Yves Masson, Sabine Elowe, Steve Bilodeau, Venkata Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
KEY FINDINGS ZNF768 is phosphorylated and degraded upon RAS activation ZNF768 depletion impairs proliferation and causes cellular senescence ZNF768 binds and represses p53 and its overexpression suffices to bypass senescence Elevated ZNF768 levels in
Externí odkaz:
https://doaj.org/article/8280dad19e4949b787cc212a7dfd3068
Autor:
Romain Villot, Audrey Poirier, Romain Devillers, Aliona Kolnoguz, Sabine Elowe, Venkata S. K. Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 6 (2021)
We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senesce
Externí odkaz:
https://doaj.org/article/db47c44d8e2b471cb74cfa54f7427180
Autor:
Valérie Janelle, Mathieu Neault, Marie-Ève Lebel, Dave Maurice De Sousa, Salix Boulet, Ludovic Durrieu, Cédric Carli, Chloé Muzac, Sébastien Lemieux, Nathalie Labrecque, Heather J. Melichar, Frédérick A. Mallette, Jean-Sébastien Delisle
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T-cell dysfunction arising upon repeated antigen exposure prevents effective immunity and immunotherapy. Using various clinically and physiologically relevant systems, we show that a prominent feature of PD-1-expressing exhausted T cells is the devel
Externí odkaz:
https://doaj.org/article/1007f9fb6e534841863c22c013ae6191
Autor:
Sathyen A. Prabhu, Omar Moussa, Christophe Gonçalves, Judith H. LaPierre, Hsiang Chou, Fan Huang, Vincent R. Richard, Pault Y. M. Ferruzo, Elizabeth M. Guettler, Isabel Soria-Bretones, Laura Kirby, Natascha Gagnon, Jie Su, Jennifer Silvester, Sai Sakktee Krisna, April A. N. Rose, Karen E. Sheppard, David W. Cescon, Frédérick A. Mallette, Rene P. Zahedi, Christoph H. Borchers, Sonia V. del Rincon, Wilson H. Miller
Publikováno v:
Molecular Cancer Therapeutics. 22:192-204
Aberrant cell-cycle progression is characteristic of melanoma, and CDK4/6 inhibitors, such as palbociclib, are currently being tested for efficacy in this disease. Despite the promising nature of CDK4/6 inhibitors, their use as single agents in melan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8fc658755ecfbbd8c0d925809d970fd
https://doi.org/10.1158/1535-7163.mct-22-0092
https://doi.org/10.1158/1535-7163.mct-22-0092
Autor:
David Papadopoli, Karine Boulay, Lawrence Kazak, Michael Pollak, Frédérick A. Mallette, Ivan Topisirovic, Laura Hulea
Publikováno v:
F1000Research, Vol 8 (2019)
The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and proliferation. Although the involvement of the mTOR pathway in regulatin
Externí odkaz:
https://doaj.org/article/a68dcd0debd44d73810c92204241959a
Autor:
Wilson H. Miller, Sonia V. del Rincon, Christoph H. Borchers, Rene P. Zahedi, Frédérick A. Mallette, David W. Cescon, Karen E. Sheppard, April A. N. Rose, Sai Sakktee Krisna, Jennifer Silvester, Jie Su, Natascha Gagnon, Laura Kirby, Isabel Soria-Bretones, Elizabeth M. Guettler, Pault Y. M. Ferruzo, Vincent R. Richard, Fan Huang, Hsiang Chou, Judith H. LaPierre, Christophe Gonçalves, Omar Moussa, Sathyen A. Prabhu
List of differentially expressed proteins annotated by cluster with pathway analysis in BLM cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00d6e0729cc0511a260e55cb63185dc
https://doi.org/10.1158/1535-7163.22523137
https://doi.org/10.1158/1535-7163.22523137
