Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Frédéric Thuaud"'
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 1, Pp o52-o53 (2013)
In the title compound, C26H24BrNO5·H2O, a synthetic analogue of natural flavagline, the cyclopentane ring adopts an envelope conformation (the flap atom bearing the phenyl group) and the vicinal phenyl and bromophenyl groups are slightly shifted rel
Externí odkaz:
https://doaj.org/article/db768fb85a704d45b291dab7fa090660
Autor:
Yohann Bernard, Nigel Ribeiro, Frédéric Thuaud, Gülen Türkeri, Ronan Dirr, Mounia Boulberdaa, Canan G Nebigil, Laurent Désaubry
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25302 (2011)
BackgroundDespite its effectiveness in the treatment of various cancers, the use of doxorubicin is limited by a potentially fatal cardiomyopathy. Prevention of this cardiotoxicity remains a critical issue in clinical oncology. We hypothesized that fl
Externí odkaz:
https://doaj.org/article/97ec74df58f24b0f91c10728b83b956b
Autor:
Go Hirai, Atsuya Muranaka, Masanobu Uchiyama, Satoko Maeda, Yusaku Nomura, Mikiko Sodeoka, Daisuke Hashizume, Akira Matsuda, Frédéric Thuaud, Daisuke Sekine, Minoru Yoshida, Hiroyuki Koshino, Akihiro Ito, Thomas Cruchter, Satoshi Ichikawa
Publikováno v:
Chemistry – A European Journal. 25:8387-8392
A synthetic methodology to access all possible stereoisomers of spectomycin A1 (SMA1) and A2 (SMA2) has been established through late-stage diversification. The key reaction for the construction of all four diastereomers is an intramolecular cyclizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd409d9015e267008a33d291231895e
https://doi.org/10.1002/chem.201901093
https://doi.org/10.1002/chem.201901093
Publikováno v:
Helvetica Chimica Acta
The convergent synthesis of proteins by multiple ligations requires segments protected at the N- and/or C-terminus with masking groups that are orthogonal to the acid and base labile protecting groups used in Fmoc-SPPS. They must be stable to solid p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787e0ef346ccc1ca91d90e995a69e0a6
https://doi.org/10.1002/hlca.201600264
https://doi.org/10.1002/hlca.201600264
Publikováno v:
Angewandte Chemie. 127:13188-13193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5542716cfa370eb65f42398c34d8b22
https://doi.org/10.1002/ange.201505379
https://doi.org/10.1002/ange.201505379
Autor:
Laurent Désaubry, Christine Basmadjian, Sittiruk Roytrakul, Duncan R. Smith, Sukathida Ubol, Frédéric Thuaud, Phitchayapak Wintachai
Publikováno v:
Microbiology and Immunology. 59:129-141
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus that recently caused large epidemics in islands in, and countries around, the Indian Ocean. There is currently no specific drug for therapeutic treatment or for use as a prophylacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d46e67840e0efbf4d90167a562bb82e4
https://doi.org/10.1111/1348-0421.12230
https://doi.org/10.1111/1348-0421.12230
Publikováno v:
Journal of the American Chemical Society
Aldehydes are widely recognized as valuable synthetic handles for the chemoselective manipulation of peptides and proteins. In this report, we show that peptides and small proteins containing the aspartic acid semialdehyde (Asa) side chain can be eas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62718d18e9143a6321e64f1fb1bdfbf
https://doi.org/10.1021/ja511231f
https://doi.org/10.1021/ja511231f
Autor:
Nigel Ribeiro, Laurent Désaubry, Eric Raymond, Maria Serova, Christophe Salomé, Thierry Chavagnan, Sandrine Faivre, Frédéric Thuaud, Armand de Gramont
Publikováno v:
European Journal of Medicinal Chemistry. 81:181-191
A series of 32 derivatives and isosteres of the mTOR inhibitor 2 were synthesized and compared for their cytotoxicity in radioresistant SQ20B cancer cell line. Several of these compounds, in particular 30b, were significantly more cytotoxic than 2. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfc319a41d7c40725fc942abdf3fcfb
https://doi.org/10.1016/j.ejmech.2014.05.014
https://doi.org/10.1016/j.ejmech.2014.05.014
Publikováno v:
Chemistry & Biology
Chemistry & biology
Chemistry & biology, 2013, 20 (3), pp.316-331. ⟨10.1016/j.chembiol.2013.02.006⟩
Chemistry & biology
Chemistry & biology, 2013, 20 (3), pp.316-331. ⟨10.1016/j.chembiol.2013.02.006⟩
Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell survival, metabolism, and inflammation. Several drugs that target PHBs have been identified and evaluated for various clinical applications. Preclinical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed3c5d677599094a4ac58608680896a
http://europepmc.org/articles/PMC7111013
http://europepmc.org/articles/PMC7111013
Publikováno v:
Organic Letters
An optimized protocol for the masking of α-ketoacids with acid-labile cyclic acetal protecting groups is reported. Unlike prior approaches, these new conditions allow the synthesis of protected α-ketoacids bearing aromatic, hindered alkyl, and prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde56713f594620aaaa9812569ce6307
https://pubmed.ncbi.nlm.nih.gov/27439001
https://pubmed.ncbi.nlm.nih.gov/27439001