Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Frédéric Saudou"'
Autor:
Hélène Vitet, Julie Bruyère, Hao Xu, Claire Séris, Jacques Brocard, Yah-Sé Abada, Benoît Delatour, Chiara Scaramuzzino, Laurent Venance, Frédéric Saudou
Publikováno v:
eLife, Vol 12 (2023)
Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains a pool of SVs, only a small fraction of which are released, it has been
Externí odkaz:
https://doaj.org/article/b69d94da556b44d79eb205d590d95d58
Autor:
Trang Thi Minh Nguyen, Rudy Gadet, Marine Lanfranchi, Romane A. Lahaye, Sozerko Yandiev, Olivier Lohez, Ivan Mikaelian, Lea Jabbour, Ruth Rimokh, Julien Courchet, Frédéric Saudou, Nikolay Popgeorgiev, Germain Gillet
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106674- (2023)
Summary: Non-lethal caspase activation (NLCA) has been linked to neurodevelopmental processes. However, how neurons control NLCA remains elusive. Here, we focused on Bcl-xL, a Bcl-2 homolog regulating caspase activation through the mitochondria. We g
Externí odkaz:
https://doaj.org/article/718d9620594a4db9b98ffb08eb9f6acb
Autor:
Aviel Even, Giovanni Morelli, Silvia Turchetto, Michal Shilian, Romain Le Bail, Sophie Laguesse, Nathalie Krusy, Ariel Brisker, Alexander Brandis, Shani Inbar, Alain Chariot, Frédéric Saudou, Paula Dietrich, Ioannis Dragatsis, Bert Brone, Loïc Broix, Jean-Michel Rigo, Miguel Weil, Laurent Nguyen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Microtubule tracks are important for the transport of molecules within axons. Here, the authors show that ATAT1, the enzyme responsible for acetylating a-tubulin, receives acetyl groups from ATP citrate lyase whose stability is regulated by Elongator
Externí odkaz:
https://doaj.org/article/56060abcde1a4c4f802c73b700424575
Autor:
Sophie Lenoir, Romane A. Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux, Laetitia Capellano, Aurélie Genoux, Noga Gershoni-Emek, Michal Geva, Michael R. Hayden, Frédéric Saudou
Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105857- (2022)
Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine-encoding CAG repeat expansion in the huntingtin (HTT) gene. HTT is involved in the axonal transport of vesicles containing brain-derived neurotrophic factor (BDNF). In HD
Externí odkaz:
https://doaj.org/article/fd15b7293989424cb83b9058a66155a8
Autor:
Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Huntington’s disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N
Externí odkaz:
https://doaj.org/article/4386a98caf404dd9a84e53f674710b00
Autor:
Nagham Badreddine, Gisela Zalcman, Florence Appaix, Guillaume Becq, Nicolas Tremblay, Frédéric Saudou, Sophie Achard, Elodie Fino
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110623- (2022)
Summary: Motor skill learning requires the activity of the dorsal striatum, with a differential global implication of the dorsomedial and dorsolateral territories. We investigate here whether and how specific striatal neurons encode the acquisition a
Externí odkaz:
https://doaj.org/article/5797c3684a8b494e80e6cadbcd903fd0
Autor:
Laure Asselin, José Rivera Alvarez, Solveig Heide, Camille S. Bonnet, Peggy Tilly, Hélène Vitet, Chantal Weber, Carlos A. Bacino, Kristin Baranaño, Anna Chassevent, Amy Dameron, Laurence Faivre, Neil A. Hanchard, Sonal Mahida, Kirsty McWalter, Cyril Mignot, Caroline Nava, Agnès Rastetter, Haley Streff, Christel Thauvin-Robinet, Marjan M. Weiss, Gladys Zapata, Petra J. G. Zwijnenburg, Frédéric Saudou, Christel Depienne, Christelle Golzio, Delphine Héron, Juliette D. Godin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Kinesins regulate intracellular transport and microtubule dynamics. Here, the authors show that KIF21B variants in humans associate with corpus callosum agenesis and microcephaly. Using mice and zebrafish, they showed the cellular mechanisms altered
Externí odkaz:
https://doaj.org/article/85fa7763d73b4163bd09f2ee5a5c74a8
Autor:
Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández, Rogan A. Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A. Ross, Udai B. Pandey, José J. Lucas, Frédéric Saudou, Maria Pennuto, Manuela Basso
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108980- (2021)
Summary: The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disru
Externí odkaz:
https://doaj.org/article/4ec24cea628a418d9972d9f2b7afcdb5
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100382- (2021)
Summary: BDNF levels are reduced in the chronically stressed brain, in the area of hippocampus. Part of the hippocampal BDNF is provided by neuronal projection of the entorhinal cortex. Studying the cortico-hippocampal transport of BDNF in vivo is te
Externí odkaz:
https://doaj.org/article/3c31f6cd5709418db5f937e5eeb931e1
Autor:
Julie Bruyère, Yah-Se Abada, Hélène Vitet, Gaëlle Fontaine, Jean-Christophe Deloulme, Aurélia Cès, Eric Denarier, Karin Pernet-Gallay, Annie Andrieux, Sandrine Humbert, Marie-Claude Potier, Benoît Delatour, Frédéric Saudou
Publikováno v:
eLife, Vol 9 (2020)
Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeostasis, but the evidence has not been consistent. In particular, signaling pathways controlling APP transport to the synapse in axons and dendrites remain to be ident
Externí odkaz:
https://doaj.org/article/b038de28dd5a440288feebeb14342e19