Design of Potent Mannose 6-Phosphate Analogues for the Functionalization of Lysosomal Enzymes To Improve the Treatment of Pompe Disease

Autor: Marie Maynadier, Coralie Bernon, Ilaria Basile, Marcel Garcia, Marc Perez, Frédéric Salgues, Afitz Da Silva, Khaled El Cheikh, Alain Morère, Magali Gary-Bobo, Pierre Cérutti, Catherine Caillaud, Martine Cerutti

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2016, 55 (47), pp.14774-14777. ⟨10.1002/anie.201607824⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2016, 55 (47), pp.14774-14777. 〈10.1002/anie.201607824〉

Improving therapeutics delivery in enzyme replacement therapy (ERT) for lysosomal storage disorders is a challenge. Herein, we present the synthesis of novel analogues of mannose 6-phosphate (M6P), known as AMFAs and functionalized at the anomeric po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8833419206a3a9f6e7c4d065cad8fa2b
https://doi.org/10.1002/ange.201607824

Design of Potent Mannose 6-Phosphate Analogues for the Functionalization of Lysosomal Enzymes To Improve the Treatment of Pompe Disease.

Autor: El Cheikh, Khaled¹, Basile, Ilaria¹, Da Silva, Afitz¹, Bernon, Coralie², Cérutti, Pierre², Salgues, Frédéric³, Perez, Marc⁴, Maynadier, Marie¹, Gary ‐ Bobo, Magali³, Caillaud, Catherine⁵, Cérutti, Martine² martine.cerutti@cnrs.fr, Garcia, Marcel³ marcel.garcia@inserm.fr, Morère, Alain³ alain.morere@umontpellier.fr

Publikováno v: Angewandte Chemie. 11/14/2016, Vol. 128 Issue 47, p14994-14997. 4p.