Výsledky vyhledávání - "Frédéric Rondu"

Potent antihyperglycaemic property of a new imidazoline derivative S-22068 (PMS 847) in a rat model of NIDDM

Autor: Xuan Wang, Agnès Pelé-Tounian, Bruno Pfeiffer, Sylvie Marc, Frédéric Rondu, Alain Ktorza, Beatrice Guardiola-Lemaitre, Luc Pénicaud, Dominique Manechez, Pierre Renard, Azzdine Lamouri, Estera Touboul, Raymond Dokhan, Jean-Jacques Godfroid

Publikováno v: British Journal of Pharmacology. 124:1591-1596

Recent data suggest that some imidazoline derivatives can lower plasma glucose in experimental animal models of diabetes. We studied the activity of an imidazoline S-22068, in rat model of non-insulin-dependent diabetes mellitus (NIDDM) produced with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::568f620ef306c5d628fc658728cdd25a
https://doi.org/10.1038/sj.bjp.0701989

Zobrazit plný text záznamu

Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats

Autor: Beatrice Guardiola-Lemaitre, Susan L.F. Chan, Agnès Pelé-Tounian, Dominique Manechez, Frédéric Rondu, Noel G. Morgan, Azzdine Lamouri, Estera Touboul, Alain Ktorza, Marie-Hélène Giroix, Luc Pénicaud, Jean-Jacques Godfroid, Bruno Pfeiffer, Pierre Renard, Gaëlle Le Bihan

Publikováno v: European Journal of Pharmacology
European Journal of Pharmacology, Elsevier, 1999, 377 (1), pp.81-7

We have investigated the possible mechanisms underlying the antihyperglycaemic effect of the imidazoline derivative S-22068. In vitro, in the presence of 5 mmol/l glucose, S-22068 (100 micromol/l) induced a significant and sustained increase in insul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e190ab8df70e520b68c8b7937a23b3
https://hal.archives-ouvertes.fr/hal-00394147

Zobrazit plný text záznamu

Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benzyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines

Autor: Jean Jacques Godfroid, P. Renard, E. Touboul, Bruno Pfeiffer, G. Le Bihan, B. Guardiola-Lemaitre, Luc Pénicaud, T. Bellahsene, Xuan Wang, Georges Dive, D. Manechez, Alain Ktorza, A. Lamouri, Frédéric Rondu

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 1997, 40, pp.3793-3803

The physiopathology of non-insulin-dependent diabetes mellitus is associated with a dysfunction in the regulation of insulin secretion. The alpha 2-adrenoceptors have been reported to be involved in this alteration, although alpha 2-antagonists conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5cfa9313bc3ab60d706aeda0472dfd
https://hal.archives-ouvertes.fr/hal-00399364

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání