Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Frédéric Princen"'
Autor:
Marie-Paule Merville, Thérèse Jarry-Guichard, Frédéric Princen, Jacques E. Gielen, Daniel Gros, Vincent Bours, Pierre A. Robe
Publikováno v:
Carcinogenesis. 22:507-513
Connexins, the structural components of gap junctions, control cell growth and differentiation and are believed to belong to a family of tumour suppressor genes. Studies on connexin localization in brain showed that several of these proteins were exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fdfe5c8c171e94c143eac353110e4c
https://doi.org/10.1093/carcin/22.3.507
https://doi.org/10.1093/carcin/22.3.507
Autor:
Jacques Gielen, Chantal Lechanteur, Philippe Delvenne, Georges Fillet, Vincent Bours, M. Lopez, Marie-Paule Merville, Frédéric Princen
Publikováno v:
Gut. 47:343-348
Background—Gene therapy is a novel approach for the treatment of cancers, and tumours disseminated in the peritoneal cavity are suitable for in situ delivery of a therapeutic gene. Aims—The eYcacy of a therapy combining a suicide gene (herpes sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c0cd103901e3fa12007d5b7d3cff6e
https://doi.org/10.1136/gut.47.3.343
https://doi.org/10.1136/gut.47.3.343
Autor:
Gustave Moonen, Brigitte Malgrange, Marie-Paule Merville, Vincent Bours, Pierre A. Robe, Jacques E. Gielen, Achille Stevenaert, Frédéric Princen, Didier Martin
Publikováno v:
Biochemical Pharmacology. 60:241-249
The herpes simplex virus type 1 thymidine kinase (HSV1-tk) suicide gene/ganciclovir system was first applied to the treatment of glioblastoma tumors, but was hampered by the low gene transfection yield. Fortunately, the gap junction-dependent diffusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c470bbacf8c15adfaa92a17a7734b5f
https://doi.org/10.1016/s0006-2952(00)00315-4
https://doi.org/10.1016/s0006-2952(00)00315-4
Autor:
Marie-Paule Merville, Marie-Josée Lopez, Jacques Gielen, Vincent Bours, Frédéric Princen, Chantal Lechanteur
Publikováno v:
Journal of Drug Targeting. 8:79-89
Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ff295c26510cc71945b0d4ed7c6de7
https://doi.org/10.3109/10611860008996854
https://doi.org/10.3109/10611860008996854
Autor:
Chantal Lechanteur, Anne-Cécile Hellin, Georges Fillet, M. Lopez, Frédéric Princen, Marie-Paule Merville, Jacques Gielen, Vincent Bours, Mohamed Bentires-Alj
Publikováno v:
Cancer Gene Therapy. 7:20-26
Gene therapy is a novel therapeutic approach that might soon improve the prognosis of some cancers. We investigated the feasibility of cytosine deaminase (CD) suicide gene therapy in a model of peritoneal carcinomatosis. DHD/K12 colorectal adenocarci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283dcb6a165ab9a1279e172213ab999e
https://doi.org/10.1038/sj.cgt.7700093
https://doi.org/10.1038/sj.cgt.7700093
Autor:
Ulrich Siebenlist, Alain Chariot, Vincent Bours, Jacques Gielen, Keith Brown, Guido Franzoso, Frédéric Princen, Marie-Paule Merville
Publikováno v:
Journal of Biological Chemistry. 274:5318-5325
Combinatorial interactions between distinct transcription factors generate specificity in the controlled expression of target genes. In this report, we demonstrated that the HOXB7 homeodomain-containing protein, which plays a key role in development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106be78e4979968a8d3197420a758ba1
https://doi.org/10.1074/jbc.274.9.5318
https://doi.org/10.1074/jbc.274.9.5318
Autor:
Georges Fillet, Frédéric Princen, S. Lo Bue, Marie-Paule Merville, Bernard Detroz, Vincent Bours, Jean-Louis Gielen, Chantal Lechanteur
Publikováno v:
Gene Therapy. 4:1189-1194
Peritoneal carcinomatosis is a common clinical situation which, in most cases, cannot be eradicated by surgery or chemotherapy. The feasibility of an HSV-TK-based suicide gene therapy for peritoneal carcinomatosis induced by DHD/K12 colon carcinoma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634c09c6e615878547d0cffd02db740a
https://doi.org/10.1038/sj.gt.3300520
https://doi.org/10.1038/sj.gt.3300520
Autor:
Nathalie Clausse, Vincenzo Castronovo, Ulla M. Wewer, Pascale Jackers, Frédéric Princen, Andrea Berti, Maria-Teresa Fernandez, Mark E. Sobel
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305:98-104
A cDNA coding for a 37 kDa polypeptide has been identified in several species as both the potential precursor of the 67 kDa laminin receptor (37LRP) and a putative ribosome-associated protein (p40). Interestingly, increased expression of this polypep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80bc497198a018ed790dd0a91ce8c4f7
https://doi.org/10.1016/0167-4781(95)00206-5
https://doi.org/10.1016/0167-4781(95)00206-5
Autor:
Olivier Jolois, Matthew Nguyen, Vincent Bours, Brigitte Malgrange, Pierre A. Robe, Frédéric Princen, Marie-Paule Merville
Publikováno v:
International journal of oncology. 25(1)
The efficacy of HSV-TK/ganciclovir gene therapy largely relies on the bystander effect, i.e. the ability of transfected cells to kill the adjacent, untrasfected cells. This mechanism itself depends chiefly on the transfer via gap junctions of phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1ffa6a54e753c401f838715aaa988b
https://pubmed.ncbi.nlm.nih.gov/15202005
https://pubmed.ncbi.nlm.nih.gov/15202005
Autor:
Jacques Gielen, Frédéric Princen, Elizabeth Franzen, Vincent Bours, M. Lopez, Marie-Paule Merville, Michel Moutschen, Chantal Lechanteur
Publikováno v:
Cancer gene therapy. 7(5)
Immunomodulating gene therapy for the treatment of malignant diseases is under extensive investigation. In this study, we induced an antitumoral immune response with murine interleukin-12 (mIL-12) and murine granulocyte-macrophage colony-stimulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a380d09181d200154e55a4cd81fa4905
https://pubmed.ncbi.nlm.nih.gov/10830715
https://pubmed.ncbi.nlm.nih.gov/10830715