Výsledky vyhledávání - "Frédéric Parmentier"

Akademický článek

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes: an exploratory analysis of immune biomarkers

Autor: Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Nicolas Bovy, Luc Vanderelst, Marcelle Van Mechelen, Pierre Vandepapelière, Christian Boitard

Publikováno v: BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)

Abstract Background IMCY-0098, a synthetic peptide developed to halt disease progression via elimination of key immune cells in the autoimmune cascade, has shown a promising safety profile for the treatment of type 1 diabetes (T1D) in a recent phase

Externí odkaz: https://doaj.org/article/3ea8c33bb1fa4f08a58cae9c56d17631

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Akademický článek

First-in-human, double-blind, randomized phase 1b study of peptide immunotherapy IMCY-0098 in new-onset type 1 diabetes

Autor: Jean Van Rampelbergh, Peter Achenbach, Richard David Leslie, Mohammad Alhadj Ali, Colin Dayan, Bart Keymeulen, Katharine R. Owen, Martin Kindermans, Frédéric Parmentier, Vincent Carlier, Roxana R. Ahangarani, Evelien Gebruers, Nicolas Bovy, Luc Vanderelst, Marcelle Van Mechelen, Pierre Vandepapelière, Christian Boitard

Publikováno v: BMC Medicine, Vol 21, Iss 1, Pp 1-16 (2023)

Abstract Background Type 1 diabetes (T1D) is a CD4+ T cell-driven autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells by CD8+ T cells. Achieving glycemic targets in T1D remains challenging in clinical practice

Externí odkaz: https://doaj.org/article/143d6c1cb5cb44809e4416a40ebd193d

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Akademický článek

A precision medicine framework using artificial intelligence for the identification and confirmation of genomic biomarkers of response to an Alzheimer's disease therapy: Analysis of the blarcamesine (ANAVEX2‐73) Phase 2a clinical study

Autor: Harald Hampel, Coralie Williams, Adrien Etcheto, Federico Goodsaid, Frédéric Parmentier, Jean Sallantin, Walter E. Kaufmann, Christopher U. Missling, Mohammad Afshar

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)

Abstract Introduction The search for drugs to treat Alzheimer's disease (AD) has failed to yield effective therapies. Here we report the first genome‐wide search for biomarkers associated with therapeutic response in AD. Blarcamesine (ANAVEX2‐73)

Externí odkaz: https://doaj.org/article/c68e3da7e9fb46fda4df787666bbe838

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Hospital admissions with influenza and impact of age and comorbidities on severe clinical outcomes in Brazil and Mexico

Autor: Clotilde El Guerche-Séblain, Adrien Etcheto, Frédéric Parmentier, Mohammad Afshar, Alejandro E. Macias, Esteban Puentes, Viviane Gresset-Bourgeois, Meral Akcay, Audrey Petitjean, Laurent Coudeville

Publikováno v: PloS one. 17(11)

Background The risk of hospitalization or death after influenza infection is higher at the extremes of age and in individuals with comorbidities. We estimated the number of hospitalizations with influenza and characterized the cumulative risk of como

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684946600a702008e1a9e0142342e148
https://pubmed.ncbi.nlm.nih.gov/36355793

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Clinical Pharmacokinetics of a Lipid-Based Formulation of Risperidone, VAL401: Analysis of a Single Dose in an Open-Label Trial of Late-Stage Cancer Patients

Autor: Frédéric Parmentier, Paul C. Taylor, Suzanne J. Dilly, George Morris, Mohammad Afshar, Coralie Williams

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics

Background and Objectives A clinical trial was conducted to measure and analyse the pharmacokinetic parameters of a lipid formulation of risperidone, VAL401. The VAL401 formulation is designed to repurpose risperidone from an antipsychotic to an aden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ceea5727eea4e6c51cfefa1065e018
https://doi.org/10.1007/s13318-018-00538-4

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Autor: Mohammad Afshar, Federico Goodsaid, Harald Hampel, Jean Sallantin, Adrien Etcheto, Christopher U. Missling, Walter E. Kaufmann, Coralie Williams, Frédéric Parmentier

Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)

Introduction The search for drugs to treat Alzheimer's disease (AD) has failed to yield effective therapies. Here we report the first genome‐wide search for biomarkers associated with therapeutic response in AD. Blarcamesine (ANAVEX2‐73), a selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d3baf09e5e57dd1ca4b23e590b8b98
http://europepmc.org/articles/PMC7167374

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A49 Modeling the dynamics of genetic cooperativity in the brain of huntington’s disease mice

Autor: Jim Rosinski, Marc Verny, Hélissande Fragnaud, Christian Neri, François-Xavier Lejeune, Erwan Bigan, Satish Sasidharan Nair, Jeff Aaronson, Frédéric Parmentier

Publikováno v: Pathogenic mechanisms.

Gene deregulation has been associated with several neurodegenerative diseases (NDs) and modeling genome-wide data such as transcriptomic data has provided holistic models of ND progression on a gene expression level. However, the consequences of gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c896ccda811de01ad88029848785087a
https://doi.org/10.1136/jnnp-2018-ehdn.47

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