Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Frédéric Ooms"'
Autor:
Frédéric Ooms, Jitka Annen, Rajanikant Panda, Paul Meunier, Luaba Tshibanda, Steven Laureys, Jeffrey M. Pollack, Bernard Surlemont
Publikováno v:
Entrepreneurship Theory and Practice. :104225872311702
Despite many calls, functional brain magnetic resonance imaging (fMRI) studies are relatively rare in the domain of entrepreneurship research. This methodological brief presents the brain-imaging method of resting-state fMRI (rs-fMRI) and illustrates
Autor:
Graeme L. Fraser, Ludivine Zoute, Sarah Rorive, Didier Schils, Alexey Lapin, Sébastien Blanc, Hamid R. Hoveyda, Jerrold M. Olefsky, Jérôme Bernard, Cyrille Evangelos Brantis, Sandrine Hospied, Sandra Guitard, François Lenoir, Joanne C. McNelis, Frédéric Ooms, Julien Parcq, Mohamed El Bousmaqui, Guillaume Dutheuil
Publikováno v:
Bioorganicmedicinal chemistry. 26(18)
Free fatty acid-2 (FFA2) receptor is a G-protein coupled receptor of interest in the development of therapeutics in metabolic and inflammatory disease areas. The discovery and optimization of an N-thiazolylamide carboxylic acid FFA2 agonist scaffold
Agonist-Induced Internalization of CC Chemokine Receptor 5 as a Mechanism to Inhibit HIV Replication
Autor:
Hamid R. Hoveyda, Dominique Schols, Jerome Bernard, Thierry Ferain, Frédéric Ooms, Graeme L. Fraser
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:655-662
The chemokine G protein-coupled receptor CC chemokine receptor 5 (CCR5) is used as an entry gate by CCR5-tropic and dual- or CCR5/CXC chemokine receptor 4-tropic strains of HIV to enter the human host cells. Thus, CCR5 antagonists (i.e., maraviroc) h
Publikováno v:
Biochimica et Biophysica Acta, Vol. 1587, No 2-3 (2002) pp. 118-125
We report a four-component partial least squares discriminant analysis (PLS) model for the prediction of blood–brain barrier (BBB) permeation using descriptors derived from 3D molecular fields. The 3D fields were transformed by VolSurf into suitabl
Autor:
T. Happaerts, Géraldine Bouchard, Didier M. Lambert, Bernard Testa, Johan Wouters, O. Oscari, Frédéric Ooms, Pierre-Alain Carrupt
Publikováno v:
Journal of Medicinal Chemistry, Vol. 45, No 9 (2002) pp. 1748-1756
A set of 29 3-alkyl 5-arylimidazolidinediones (hydantoins) with affinity for the human cannabinoid CB1 receptor was studied for their lipophilicity and conformational properties in order to delineate a pharmacophore. These molecules constitute a new
Autor:
Johan Wouters, Frédéric Ooms
Publikováno v:
Current Pharmaceutical Design. 7:529-545
Crystal structures of small molecules (i.e. isolated ligands) are a source of valuable structural information helpful in the process of drug design (pharmacophore model elaborations, 3D QSAR, docking, and de novo design). Indeed, structural data obta
Autor:
Clinton Van’t Land, Sébastien Delvosal, Neal Castagnoli, Frédéric Ooms, Cornelis J. Van der Schyf, Gisella Dockendolf, Johan Wouters, Thomas E. Glass, François Durant
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1781-1787
The "reduced" haloperidol pyridinium metabolite (RHPP+) is found in the brain, plasma and urine of patients treated with the neuroleptic drug haloperidol (HP). RHPP+ is suspected to be neurotoxic through a mechanism that entails interference with the
Publikováno v:
Tetrahedron Letters. 38(43):7625-7628
Although γ-sulfonyloxy-benzylselenides react with butyllithium to produce stereospecifically aryl cyclopropanes, the corresponding γ-silyloxy-benzylselenides lead to a stereoisomeric mixture of γ-hydroxy-α-silyl-benzylselenides via the retro-[1,4
Publikováno v:
European Journal of Medicinal Chemistry. 32:721-730
Summary Different families of heterocycles containing 2 to 4 nitrogen atoms (oxadiazolones, tetrazoles and oxadiazinone derivatives, so-called diazoheterocyclics) are currently used as lead compounds for the design of reversible and selective monoami