Plant and mouse EB1 proteins have opposite intrinsic properties on the dynamic instability of microtubules

Autor: Arthur T. Molines, Virginie Stoppin-Mellet, Isabelle Arnal, Frédéric M. Coquelle

Publikováno v: BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)

Abstract Objective Most eukaryotic cells contain microtubule filaments, which play central roles in intra-cellular organization. However, microtubule networks have a wide variety of architectures from one cell type and organism to another. Nonetheles

Externí odkaz: https://doaj.org/article/72b60021ec034b089ccf9dc335a6d4a9

Protein tyrosine phosphatase 4A3 (PTP4A3/PRL-3) promotes the aggressiveness of human uveal melanoma through dephosphorylation of CRMP2

Autor: Océane Anezo, Laura Duciel, Koushik Mandal, David Gentien, Simon Saule, Nathalie Planque, Frédéric M. Coquelle, Jean-Baptiste Manneville, Cécile Laurent

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.2990. ⟨10.1038/s41598-019-39643-y⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)

Uveal melanoma (UM) is an aggressive tumor in which approximately 50% of patients develop metastasis. Expression of the PTP4A3 gene, encoding a phosphatase, is predictive of poor patient survival. PTP4A3 expression in UM cells increases their migrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e93c0e987ce0dd81d692274240ed74
https://hal.archives-ouvertes.fr/hal-02332471

Native metabotropic glutamate receptor 4 depresses synaptic transmission through an unusual Gαq transduction pathway

Autor: Frédéric M. Coquelle, Simon Bossi, Heather McLean, Raoudha Dammak, Marie-Ange Richard, Paulette Decottignies, Christelle Cadilhac, Thomas Bessiron, Solenne Chardonnet, Pierre Le Maréchal, Fabrice Ango, Cathy Isaura Ramos, Hervé Daniel, Céline Boursier, Catherine Berrier

Publikováno v: Neuropharmacology
Neuropharmacology, Elsevier, 2017, 121, pp.247-260. ⟨10.1016/j.neuropharm.2017.04.036⟩
Neuropharmacology, Elsevier, 2017, 121, pp.247-260. 〈10.1016/j.neuropharm.2017.04.036〉
Neuropharmacology, 2017, 121, pp.247-260. ⟨10.1016/j.neuropharm.2017.04.036⟩

International audience; In cerebellar cortex, mGlu4 receptors located on parallel fibers play an essential role in normal motor function, but the molecular mechanisms involved are not yet completely understood. Using a strategy combining biochemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f55656f16fb2b81ff17933f10d169dd
https://hal.archives-ouvertes.fr/hal-01571666

Structural basis of EB1 effects on microtubule dynamics

Autor: Benjamin Vitre, Isabelle Arnal, Frédéric M. Coquelle

Publikováno v: Biochemical Society Transactions
Biochemical Society Transactions, Portland Press, 2009, 37 (Pt 5), pp.997-1001. ⟨10.1042/BST0370997⟩
Biochemical Society Transactions, 2009, 37 (Pt 5), pp.997-1001. ⟨10.1042/BST0370997⟩

International audience; +TIPs (plus-end tracking proteins) are an increasing group of molecules that localize preferentially to the end of growing microtubules. +TIPs regulate microtubule dynamics and contribute to the organization of the microtubula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b3abba59e809fb3275a142e90636e4
https://doi.org/10.1042/bst0370997

Missense mutations resulting in type 1 lissencephaly

Autor: Orly Reiner, Frédéric M. Coquelle

Publikováno v: CMLS Cellular and Molecular Life Sciences. 62:425-434

Proper human brain formation is dependent upon the integrated activity of multiple genes. Malfunctioning of key proteins results in brain developmental abnormalities. Mutation(s) in the LIS1 gene or the X-linked gene doublecortin (DCX) results in a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909a0d944cb8bd78f8fad402039f6d0a
https://doi.org/10.1007/s00018-004-4344-0