Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Frédéric Lozac'h"'
Autor:
Caroline Welte, Hans-Arno Synal, Simon Fahrni, Frédéric Lozac'h, Markus Walles, Joël Bourquin, Daniele De Maria, Gian Camenisch, David Pearson
Publikováno v:
Bioanalysis. 10:321-339
Aim: Although regulatory guidances require human metabolism information of drug candidates early in the development process, the human mass balance study (or hADME study), is performed relatively late. hADME studies typically involve the administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f719b03255d45ce236b0dcec39c94ab8
https://doi.org/10.4155/bio-2017-0216
https://doi.org/10.4155/bio-2017-0216
Autor:
Hans-Arno Synal, Cyrille Marvalin, Frédéric Lozac'h, Lukas Wacker, Markus Walles, Simon Fahrni, Daniele De Maria, Gian Camenisch
Publikováno v:
Drug Metabolism and Pharmacokinetics, 39
Although Accelerator Mass Spectrometry (AMS) offers unparalleled sensitivity by investigating the fate of 14C-labeled compounds within the organism, its widespread use in ADME (absorption, distribution, metabolism, excretion) studies is limited. Conv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fb4ad30ee9e35c9f1031e5fe77bb69
https://doi.org/10.1016/j.dmpk.2021.100400
https://doi.org/10.1016/j.dmpk.2021.100400
Autor:
Frédéric, Lozac'h, Simon, Fahrni, Daniele De, Maria, Caroline, Welte, Joël, Bourquin, Hans-Arno, Synal, David, Pearson, Markus, Walles, Gian, Camenisch
Publikováno v:
Bioanalysis. 10(5)
Although regulatory guidances require human metabolism information of drug candidates early in the development process, the human mass balance study (or hADME study), is performed relatively late. hADME studies typically involve the administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fcfe15aa745e9da363fa33529fc7a7c7
https://pubmed.ncbi.nlm.nih.gov/29451392
https://pubmed.ncbi.nlm.nih.gov/29451392
Publikováno v:
Metabolite Safety in Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4089cd6006b81bec27e5ce237eaadced
https://doi.org/10.1002/9781118949689.ch10
https://doi.org/10.1002/9781118949689.ch10
Autor:
Joel Krauser, Esther van de Kerkhof, Frédéric Lozac'h, Alexandre Catoire, Thomas Faller, Jesper Christensen, Piet Swart, Karine Litherland, Francois Natt, Jürg Hunziker, Maxime Garnier
Publikováno v:
Pharmacology Research & Perspectives
The chemical modification 2′‐O‐methyl of nucleosides is often used to increase siRNA stability towards nuclease activities. However, the metabolic fate of modified nucleosides remains unclear. Therefore, the aim of this study was to determine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b71cf5c11f6d9a383a30b18ac695f4a
https://doi.org/10.1002/prp2.209
https://doi.org/10.1002/prp2.209
Publikováno v:
Drug Discovery Today, 6, 21, 873-879
Modern accelerator mass spectrometry (AMS) methods enable the routine application of this technology in drug development. By the administration of a (14)C-labelled microdose or microtrace, pharmacokinetic (PK) data, such as mass balance, metabolite p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc220723d012b9ad7c8bb2b1b1b3eda
http://resolver.tudelft.nl/uuid:fb91760d-ea00-4197-8fbd-411adb403bba
http://resolver.tudelft.nl/uuid:fb91760d-ea00-4197-8fbd-411adb403bba
Autor:
Piet Swart, Frédéric Lozac'h, Felix Waldmeier, Kevin R. Kelly, Yanfeng Wang, Patrick Urban, Suraj Anand, Eugene Tan, Chris H. Takimoto, Alain C. Mita, Markus Zollinger, Monica M. Mita
Publikováno v:
Investigational New Drugs. 31:605-615
A phase 1, open-label, non-randomized, single center study was conducted to determine the pharmacokinetics, distribution, metabolism, elimination, and mass balance of patupilone in patients with advanced solid tumors. Five patients with advanced soli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b63082020fd56d339e84eb78f6fc6a1
https://doi.org/10.1007/s10637-012-9838-2
https://doi.org/10.1007/s10637-012-9838-2
Autor:
Markus, Zollinger, Frédéric, Lozac'h, Eunju, Hurh, Corinne, Emotte, Hounayda, Bauly, Piet, Swart
Publikováno v:
Cancer chemotherapy and pharmacology. 74(1)
The absorption, distribution, metabolism, and excretion of the hedgehog pathway inhibitor sonidegib (LDE225) were determined in healthy male subjects.Six subjects received a single oral dose of 800 mg ¹⁴C-sonidegib (74 kBq, 2.0 µCi) under fasting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e8fbdba2fd427aad7d9116e888feacb
https://pubmed.ncbi.nlm.nih.gov/24817600
https://pubmed.ncbi.nlm.nih.gov/24817600
Autor:
Brian M. McMullen, Paul C.M. van Noort, Henny van den Heuvel, Frédéric Lozac'h, Thomas Le Couriaut
Publikováno v:
Environmental toxicology and chemistry. 24(4)
The maximum amounts of phenanthrene that can be taken up in both the slowly desorbing domain and the very slowly desorbing domain of 19 soils and sediments were determined by measuring the desorption of phenanthrene added at high loadings associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90d57d0071862847efa60eeb955d325
https://pubmed.ncbi.nlm.nih.gov/15839556
https://pubmed.ncbi.nlm.nih.gov/15839556
Autor:
Zollinger, Markus, Lozac'h, Frédéric, Hurh, Eunju, Emotte, Corinne, Bauly, Hounayda, Swart, Piet
Publikováno v:
Cancer Chemotherapy & Pharmacology; Jul2014, Vol. 74 Issue 1, p63-75, 13p