Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Frédéric Lirussi"'
Autor:
T. E. Lopez, H. Zhang, E. Bouysse, F. Neiers, X. Y. Ye, C. Garrido, M. Wendremaire, Frédéric Lirussi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract During labor, monocytes infiltrate massively the myometrium and differentiate into macrophages secreting high levels of reactive oxygen species and of pro-inflammatory cytokines (i.e. IL-1β), leading to myometrial contraction. Although IL-1
Externí odkaz:
https://doaj.org/article/dc4b943a3a8c4d76802f6e89b4708507
Autor:
Mathieu Schwartz, Nicolas Petiot, Jeanne Chaloyard, Véronique Senty-Segault, Frédéric Lirussi, Patrick Senet, Adrien Nicolai, Jean-Marie Heydel, Francis Canon, Sanjiv Sonkaria, Varsha Khare, Claude Didierjean, Fabrice Neiers
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 758 (2024)
This study presents a comprehensive analysis of the dimerization interfaces of fly GSTs through sequence alignment. Our investigation revealed GSTE1 as a particularly intriguing target, providing valuable insights into the variations within Delta and
Externí odkaz:
https://doaj.org/article/54e82adfb4474af494580a88b3c19d1b
Autor:
Ying-Hui Yuan, Nian-Dong Mao, Ji-Long Duan, Hang Zhang, Carmen Garrido, Frédéric Lirussi, Yuan Gao, Tian Xie, Xiang-Yang Ye
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
AbstractAdaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr kinases, is a specific key kinase regulating Thr156 phosphorylation at the μ2 subunit of the adapter complex-2 (AP-2) protein. Due to their important biological
Externí odkaz:
https://doaj.org/article/3e6adc2500364272ade4b76cc24de15a
Autor:
Li Xu, Yuan Wang, Xingrui He, Yuan Gao, Frédéric Lirussi, Yi Zhou, Carmen Garrido, Hang Zhang, Tian Xie, Xiang-Yang Ye
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 7, Iss , Pp 100103- (2023)
Heat shock protein 110 (HSP110) is an emerging biological target for development of drug to treat colorectal cancer. In the present study, we designed and synthesized a series of novel small-molecule inhibitors of HSP110 based on previously reported
Externí odkaz:
https://doaj.org/article/58997d216e374dd38adac42e4da926ac
Autor:
Tatiana Lopez, Maeva Wendremaire, Jimmy Lagarde, Oriane Duquet, Line Alibert, Brice Paquette, Carmen Garrido, Frédéric Lirussi
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2784 (2022)
Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events
Externí odkaz:
https://doaj.org/article/cf28f21b87f645ecb6c9081aa6ea316a
Autor:
Maeva Wendremaire, Tatiana E. Lopez, Marina Barrichon, Hang Zhang, Tarik Hadi, Xiang-Yang Ye, Fabrice Neiers, Marc Bardou, Paul Sagot, Carmen Garrido, Frédéric Lirussi
Publikováno v:
Cells, Vol 11, Iss 6, p 954 (2022)
Maternal obesity is associated with a wide spectrum of labour disorders, including preterm birth. Leptin, a pro-inflammatory adipokine and a key factor of obesity, is suspected to play a major role in these disorders. OB-R, its receptor, is expressed
Externí odkaz:
https://doaj.org/article/d3a68d72671c4825990ef37d87f95059
Autor:
Frédéric Lirussi, Kyrylo Pyrshev, Semen Yesylevskyy, Timothée Rivel, Tatiana Lopez, Eleonore Coppens, Simona Mura, Patrick Couvreur, Christophe Ramseyer
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1869(2)
Up to now the lipid bilayers were rarely considered as targets in cancer therapy despite pronounced differences in lipid composition between plasma membranes of benign and malignant cells. In this study we demonstrate that the lipid bilayer of the pl
Autor:
Tarik Hadi, Frédéric Lirussi, Lisa Lagorgette, Aamir Akbarali, Evgeniy Eruslanov, Bernhard Ryffel, Ettore Appella, Alexey Petukhov, Jeanne Chaloyard, Sharlyn J. Mazur, Oleg N. Demidov, Sunil Singhal, Bogdan B. Grigorash, E. V. Baidyuk, Hiroyasu Sakai, Burhan Uyanik, Anastasia R. Goloudina, Carmen Garrido, Lino Tessarollo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
PPM1D/Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human solid tumors. Recent reports associate gain-of-function mutations of PPM1D in immune cells with worse outcomes for several human cancers. Here we sho
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:435-452
Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being investigated for potential anticancer treatment in clinical trials.Area covered:
Design, synthesis and antitumor efficacy evaluation of a series of novel β-elemene-based macrocycles
Autor:
Xiang Qi, Songwei Jiang, Zi Hui, Yuan Gao, Yang Ye, Frédéric Lirussi, Carmen Garrido, Li Xu, Xingrui He, Renren Bai, Xiang-Yang Ye, Tian Xie
Publikováno v:
Bioorganic & Medicinal Chemistry. 74:117049
β-Elemene is the major constituent of the antitumor drugs elemene extract approved in China. By incorporating macrocyclization strategy into the β-elemene skeleton, we designed a series of novel macrocycles retaining three key carbon-carbon double