Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione

Autor: Paul Baxter, Francesc X. Soriano, Larry G. Higgins, John D. Hayes, James Varley, Sofia Papadia, Frédéric Léveillé, Giles E. Hardingham

Publikováno v: Journal of Neurochemistry. 107:533-543

Peroxiredoxins are an important family of cysteine-based antioxidant enzymes that exert a neuroprotective effect in several models of neurodegeneration. However, under oxidative stress they are vulnerable to inactivation through hyperoxidation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ac5021e009236d17ad91e2742aa9219
https://doi.org/10.1111/j.1471-4159.2008.05648.x

Neuronal Activity Controls the Antagonistic Balance Between Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α and Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors in Regulating Antioxidant Defenses

Autor: Giles E. Hardingham, Karen F.S. Bell, Frédéric Léveillé, Francesc X. Soriano, Clare A. Puddifoot, Sofia Papadia

Publikováno v: Soriano, F X, Leveille, F, Papadia, S, Bell, K F S, Puddifoot, C & Hardingham, G E 2011, ' Neuronal Activity Controls the Antagonistic Balance Between Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α and Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors in Regulating Antioxidant Defenses ', Antioxidants and Redox Signaling, vol. 14, no. 8, pp. 1425-1436 . https://doi.org/10.1089/ars.2010.3568

Transcriptional coactivators and corepressors often have multiple targets and can have opposing actions on transcription and downstream physiological events. The coactivator peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α is under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75eecb7041bca956f4e71347838c7f38
https://europepmc.org/articles/PMC3044457/

Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation

Autor: Frédéric Léveillé, Laurence Had-Aissouni, C. Melon, E. Gouix, Olivier Nicole, Alain Buisson

Publikováno v: Molecular and Cellular Neuroscience
Molecular and Cellular Neuroscience, Elsevier, 2009, 40, pp.463-473
Molecular and Cellular Neuroscience, 2009, 40, pp.463-473

Evidence have accumulated that reverse glutamate uptake plays a key role in the pathophysiology of cerebral ischemia. Here, we investigated the effects of glial glutamate transporter dysfunction on neuronal survival using the substrate inhibitor of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059c1e4f563d353c20a19b900540c5ba
https://pubmed.ncbi.nlm.nih.gov/19340933

2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo

Autor: Mónica Fernández-Monreal, Eric T. MacKenzie, Frédéric Léveillé, Alain Buisson, José P. López-Atalaya, Denis Vivien, Karim Benchenane, Carine Ali, Géraldine Liot, Antonio Ruocco

Publikováno v: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 24(10)

Tissue-type plasminogen activator (tPA) is available for the treatment of thromboembolic stroke in humans. However, adverse effects of tPA have been observed in animal models of ischemic brain injuries. In the present study, we have used a synthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3a5ad4b62afe3c5936870bfbfb2a6b
https://pubmed.ncbi.nlm.nih.gov/15529015

Is tissue-type plasminogen activator a neuromodulator?

Autor: Laurent Plawinski, Guojun Bu, Alain Buisson, José P. López-Atalaya, Karim Benchenane, Eric T. MacKenzie, Mónica Fernández-Monreal, Mathias Cacquevel, Frédéric Léveillé, Denis Vivien

Publikováno v: Molecular and cellular neurosciences. 25(4)

In the last few years, it has been evidenced that serine proteases play key roles in the mammalian brain, both in physiological and pathological conditions. It has been well established that among these serine proteases, the tissue-type plasminogen a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d08f2265132978284a8acc582e37e2
https://pubmed.ncbi.nlm.nih.gov/15080889