Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Frédéric H-T Allain"'
Autor:
Lucía Álvarez, Kevin Haubrich, Louisa Iselin, Laurent Gillioz, Vincenzo Ruscica, Karine Lapouge, Sandra Augsten, Ina Huppertz, Nila Roy Choudhury, Bernd Simon, Pawel Masiewicz, Mathilde Lethier, Stephen Cusack, Katrin Rittinger, Frank Gabel, Alexander Leitner, Gracjan Michlewski, Matthias W. Hentze, Frédéric H. T. Allain, Alfredo Castello, Janosch Hennig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut
Externí odkaz:
https://doaj.org/article/d8245675d28e4b2bbc482fdb79f08563
Autor:
Matthieu Bergé, Sébastien Campagne, Johann Mignolet, Seamus Holden, Laurence Théraulaz, Suliana Manley, Frédéric H-T Allain, Patrick H Viollier
Publikováno v:
eLife, Vol 5 (2016)
Although free-living and obligate intracellular bacteria are both polarized it is unclear whether the underlying polarization mechanisms and effector proteins are conserved. Here we dissect at the cytological, functional and structural level a conser
Externí odkaz:
https://doaj.org/article/1c80183e9d3c4a9ca95a4d53c49b01d9
Autor:
Piotr Klukowski, Fred F. Damberger, Frédéric H.-T. Allain, Hideo Iwai, Harindranath Kadavath, Theresa A. Ramelot, Gaetano T. Montelione, Roland Riek, Peter Güntert
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-13 (2024)
Abstract Multidimensional NMR spectra are the basis for studying proteins by NMR spectroscopy and crucial for the development and evaluation of methods for biomolecular NMR data analysis. Nevertheless, in contrast to derived data such as chemical shi
Externí odkaz:
https://doaj.org/article/d607f976b6f94288a6a64321321d3e7a
Autor:
Mario Schubert, Silvia Bleuler-Martinez, Alex Butschi, Martin A Wälti, Pascal Egloff, Katrin Stutz, Shi Yan, Mayeul Collot, Jean-Maurice Mallet, Iain B H Wilson, Michael O Hengartner, Markus Aebi, Frédéric H-T Allain, Markus Künzler
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002706 (2012)
Discrimination between self and non-self is a prerequisite for any defence mechanism; in innate defence, this discrimination is often mediated by lectins recognizing non-self carbohydrate structures and so relies on an arsenal of host lectins with di
Externí odkaz:
https://doaj.org/article/45c7d5b3702e41178f59d545fd19aa0b
Autor:
Ahmed Moursy, Antoine Cléry, Stefan Gerhardy, Katharina M. Betz, Sanjana Rao, Jarosław Mazur, Sébastien Campagne, Irene Beusch, Malgorzata M. Duszczyk, Mark D. Robinson, Vikram Govind Panse, Frédéric H.-T. Allain
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the RNA sequence(s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 during the splicing reaction remain elusive. Here, we developed a split-iC
Externí odkaz:
https://doaj.org/article/4a88fb1ca6af451d9d41da0376069163
Autor:
Georg Dorn, Christoph Gmeiner, Tebbe de Vries, Emil Dedic, Mihajlo Novakovic, Fred F. Damberger, Christophe Maris, Esteban Finol, Chris P. Sarnowski, Joachim Kohlbrecher, Timothy J. Welsh, Sreenath Bolisetty, Raffaele Mezzenga, Ruedi Aebersold, Alexander Leitner, Maxim Yulikov, Gunnar Jeschke, Frédéric H.-T. Allain
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract RNA-binding proteins (RBPs) are crucial regulators of gene expression, often composed of defined domains interspersed with flexible, intrinsically disordered regions. Determining the structure of ribonucleoprotein (RNP) complexes involving s
Externí odkaz:
https://doaj.org/article/6ecfd082137440199e61e0254d4f1997
Autor:
Sébastien Campagne, Daniel Jutzi, Florian Malard, Maja Matoga, Ksenija Romane, Miki Feldmuller, Martino Colombo, Marc-David Ruepp, Frédéric H-T. Allain
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Pharmacologic depletion of RNA-binding motif 39 (RBM39) using aryl sulfonamides represents a promising anti-cancer therapy but requires high levels of the adaptor protein DCAF15. Consequently, novel approaches to deplete RBM39 in an DCAF15-i
Externí odkaz:
https://doaj.org/article/79b7174732b448a7b9de0ce1ce1bf801
Autor:
Thomas Wiegand, Denis Lacabanne, Anahit Torosyan, Julien Boudet, Riccardo Cadalbert, Frédéric H.-T. Allain, Beat H. Meier, Anja Böckmann
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Today, the sedimentation of proteins into a magic-angle spinning (MAS) rotor gives access to fast and reliable sample preparation for solid-state Nuclear Magnetic Resonance (NMR), and this has allowed for the investigation of a variety of non-crystal
Externí odkaz:
https://doaj.org/article/ac55a9986b3148cc9e409b2ba7bfa6cc
Autor:
Sirine Nouri, Julien Boudet, Hiang Dreher-Teo, Frédéric H.-T. Allain, Rudi Glockshuber, Loïc Salmon, Christoph Giese
Publikováno v:
Angewandte Chemie. International Edition
In NMR spectroscopy, residual dipolar couplings (RDCs) have emerged as one of the most exquisite probes of biological structure and dynamics. The measurement of RDCs relies on the partial alignment of the molecule of interest, for example by using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdeffd38df3ea733f7a417c39ca507a7
https://doi.org/10.1002/anie.202305120
https://doi.org/10.1002/anie.202305120
Autor:
Markus Blatter, Charlotte Meylan, Antoine Cléry, Roberto Giambruno, Yaroslav Nikolaev, Michel Heidecker, Jessica Arvindbhai Solanki, Manuel O. Diaz, Davide Gabellini, Frédéric H.-T. Allain
Publikováno v:
Science Advances, 9 (16)
Mixed-lineage leukemia 1 (MLL1) is a transcription activator of the HOX family, which binds to specific epigenetic marks on histone H3 through its third plant homeodomain (PHD3) domain. Through an unknown mechanism, MLL1 activity is repressed by cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03131604c531e493919b5477b8954e8
