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pro vyhledávání: '"Frédéric G Leroux"'
Autor:
Stephen Matthews, Ai C Wong, Peter Cherepanov, Frédéric Elustondo, Andrea Di Fonzo, Frédéric G Leroux, Siobhan M. Hughes, Ambrosius P. Snijders
Publikováno v:
Nature structuralmolecular biology. 19(11)
CDC7 is a serine/threonine kinase that is essential for the initiation of eukaryotic DNA replication. CDC7 activity is controlled by its activator, DBF4. Here we present crystal structures of human CDC7-DBF4 in complex with a nucleotide or ATP-compet