Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice

Autor: Lorraine Smith, Wendy Klément, Léonie Dopavogui, Frédéric de Bock, Frédéric Lasserre, Sharon Barretto, Céline Lukowicz, Anne Fougerat, Arnaud Polizzi, Benoist Schaal, Bruno Patris, Colette Denis, Guylène Feuillet, Cécile Canlet, Emilien L Jamin, Laurent Debrauwer, Laila Mselli-Lakhal, Nicolas Loiseau, Hervé Guillou, Nicola Marchi, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre

Publikováno v: Environment International, Vol 144, Iss , Pp 106010- (2020)

Background: We recently demonstrated that chronic dietary exposure to a mixture of pesticides at low-doses induced sexually dimorphic obesogenic and diabetogenic effects in adult mice. Perinatal pesticide exposure may also be a factor in metabolic di

Externí odkaz: https://doaj.org/article/d7d9d1d5d2174beca38b3540364e88a2

Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier

Autor: Marion Clé, Caroline Desmetz, Jonathan Barthelemy, Marie-France Martin, Orianne Constant, Ghizlane Maarifi, Vincent Foulongne, Karine Bolloré, Yaël Glasson, Frédéric De Bock, Marine Blaquiere, Lucie Dehouck, Nelly Pirot, Edouard Tuaillon, Sébastien Nisole, Fatiha Najioullah, Philippe Van de Perre, André Cabié, Nicola Marchi, Fabien Gosselet, Yannick Simonin, Sara Salinas

Publikováno v: mBio, Vol 11, Iss 4 (2020)

ABSTRACT The blood-brain barrier (BBB) largely prevents toxins and pathogens from accessing the brain. Some viruses have the ability to cross this barrier and replicate in the central nervous system (CNS). Zika virus (ZIKV) was responsible in 2015 to

Externí odkaz: https://doaj.org/article/a806d0852bba4648addb7368645ffcc7

Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy

Autor: Marine Blaquière, Fabien Boux, Vasile Stupar, Nora Collomb, Emmanuel L. Barbier, Nicola Marchi, Frédéric de Bock, Lucile Mazière, Antoine Depaulis, Florence Forbes, Emma Zub

Publikováno v: Epilepsia
Epilepsia, 2021, 62 (5), pp.1244-1255. ⟨10.1111/epi.16886⟩
Epilepsia, Wiley, 2021, 62 (5), pp.1244-1255. ⟨10.1111/epi.16886⟩

International audience; Objective: Improving the identification of the epileptogenic zone and associated seizure-spreading regions represents a significant challenge. Innovative brain-imaging modalities tracking neurovascular dynamics during seizures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071ad317b1459e0ca0b752da29795057
https://doi.org/10.1111/epi.16886

Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice

Autor: Wendy Klement, Hervé Guillou, Léonie Dopavogui, Lorraine Smith, Laurence Gamet-Payrastre, Guylène Feuillet, Nicola Marchi, Arnaud Polizzi, Frédéric de Bock, Emilien L. Jamin, Laurent Debrauwer, Sandrine Ellero-Simatos, Céline Lukowicz, Benoist Schaal, Sharon Barretto, Nicolas Loiseau, Bruno Patris, Cécile Canlet, Laila Mselli-Lakhal, Frédéric Lasserre, Anne Fougerat, Colette Denis

Publikováno v: Environment International
Environment International, Elsevier, 2020, 144, pp.106010. ⟨10.1016/j.envint.2020.106010⟩
Environment International, 2020, 144, pp.106010. ⟨10.1016/j.envint.2020.106010⟩
Environment International, Vol 144, Iss, Pp 106010-(2020)

International audience; Background: We recently demonstrated that chronic dietary exposure to a mixture of pesticides at low-doses induced sexually dimorphic obesogenic and diabetogenic effects in adult mice. Perinatal pesticide exposure may also be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a9b2c96c167dc2cdf2054a7d4139e0
https://hal.archives-ouvertes.fr/hal-02912899

Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature

Autor: Laura Tassi, Julie Perroy, Emma Zub, Rita Garbelli, Laura Rossini, Wendy Klement, Benoit Girard, Federica Bertaso, Marine Blaquière, Nicola Marchi, Frédéric de Bock

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2018, 113, pp.70-81. ⟨10.1016/j.nbd.2018.02.002⟩
Neurobiology of Disease, Vol 113, Iss, Pp 70-81 (2018)

Background Cerebrovascular dysfunction and inflammation occur in epilepsy. Here we asked whether pericytes, a pivotal cellular component of brain capillaries, undergo pathological modifications during experimental epileptogenesis and in human epileps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5be585d610cdf3240c723a86e5c9c9f
https://doi.org/10.1016/j.nbd.2018.02.002