Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Frédéric D Sweeney"'
Autor:
Genevieve M Vidanes, Frédéric D Sweeney, Sarah Galicia, Stephanie Cheung, John P Doyle, Daniel Durocher, David P Toczyski
Publikováno v:
PLoS Biology, Vol 8, Iss 1, p e1000286 (2010)
The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage checkpoint, in addition to its numerous roles in mitotic progression. The process of adaptation occurs when cells are presented with persistent or irreparable DN
Externí odkaz:
https://doaj.org/article/b7d9df73f8ff4948a990b814f3cb3ecd
Autor:
C. Jane McGlade, Derek F. Ceccarelli, Leanne E. Wybenga-Groot, Daniel Durocher, Frédéric D. Sweeney, Cynthia S. Ho, Frank Sicheri
Publikováno v:
Cellular Signalling. 26:1825-1836
The protein kinase Rad53 is a key regulator of the DNA damage checkpoint in budding yeast. Its human ortholog, CHEK2, is mutated in familial breast cancer and mediates apoptosis in response to genotoxic stress. Autophosphorylation of Rad53 at residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff06cc48a24efbd623d2e5f838b4aafd
https://doi.org/10.1016/j.cellsig.2014.05.004
https://doi.org/10.1016/j.cellsig.2014.05.004
Publikováno v:
Current Biology. 15:1364-1375
Summary Background: The DNA damage checkpoint is a protein kinase-based signaling system that detects and signals physical alterations in DNA. Despite having identified many components of this signaling cascade, the exact mechanisms by which checkpoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c90b4c1781740dea8cf35b09eb77371
https://doi.org/10.1016/j.cub.2005.06.063
https://doi.org/10.1016/j.cub.2005.06.063
Autor:
Sarah Galicia, David P. Toczyski, Daniel Durocher, Stephanie K. Cheung, Frédéric D. Sweeney, Genevieve M. Vidanes, John P. Doyle
Publikováno v:
PLoS Biology
PLoS biology, vol 8, iss 1
PLoS Biology, Vol 8, Iss 1, p e1000286 (2010)
PLoS biology, vol 8, iss 1
PLoS Biology, Vol 8, Iss 1, p e1000286 (2010)
The mechanistic role of the yeast kinase CDC5, in allowing cells to adapt to the presence of irreparable DNA damage and continue to divide, is revealed.
The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage che
The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e3561b23f6ff881954caccb405ffdb
http://europepmc.org/articles/PMC2811153
http://europepmc.org/articles/PMC2811153
Autor:
Frédéric D. Sweeney, Timothy M. Thomson, Laurence Pelletier, Stephanie Panier, Jarkko Ylanko, Shinichiro Nakada, Jan Wildenhain, Nadine K. Kolas, Megan Mendez, Richard Chahwan, J. Ross Chapman, Daniel Durocher, Stephen P. Jackson
Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage mediator protein MDC1, the p53-binding protein 1 (53BP1), and the breast cancer susceptibility protein BRCA1 to sites of damaged DNA. Here, we reveal that the ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60a2a8d3386d1560f3c913dd6213b2c
https://doi.org/10.5167/uzh-168168
https://doi.org/10.5167/uzh-168168
Autor:
Pamela Kanellis, Mark Gagliardi, Judit P Banath, Rachel K Szilard, Shinichiro Nakada, Sarah Galicia, Frederic D Sweeney, Diane C Cabelof, Peggy L Olive, Daniel Durocher
Publikováno v:
PLoS Genetics, Vol 3, Iss 8, p e134 (2007)
Genome instability is a hallmark of cancer cells. One class of genome aberrations prevalent in tumor cells is termed gross chromosomal rearrangements (GCRs). GCRs comprise chromosome translocations, amplifications, inversions, deletion of whole chrom
Externí odkaz:
https://doaj.org/article/543d1111c50c4b1cac209eefebc8af72