Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Frédéric Chédin"'
Autor:
David Rombaut, Carine Lefèvre, Tony Rached, Sabrina Bondu, Anne Letessier, Raphael M. Mangione, Batoul Farhat, Auriane Lesieur-Pasquier, Daisy Castillo-Guzman, Ismael Boussaid, Chloé Friedrich, Aurore Tourville, Magali De Carvalho, Françoise Levavasseur, Marjorie Leduc, Morgane Le Gall, Sarah Battault, Marie Temple, Alexandre Houy, Didier Bouscary, Lise Willems, Sophie Park, Sophie Raynaud, Thomas Cluzeau, Emmanuelle Clappier, Pierre Fenaux, Lionel Adès, Raphael Margueron, Michel Wassef, Samar Alsafadi, Nicolas Chapuis, Olivier Kosmider, Eric Solary, Angelos Constantinou, Marc-Henri Stern, Nathalie Droin, Benoit Palancade, Benoit Miotto, Frédéric Chédin, Michaela Fontenay
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences are poorly understoo
Externí odkaz:
https://doaj.org/article/123566d884df484c9b7e6a5d549470f7
Autor:
Hongchang Zhao, Stella R Hartono, Kirtney Mae Flores de Vera, Zheyuan Yu, Krishni Satchi, Tracy Zhao, Roger Sciammas, Lionel Sanz, Frédéric Chédin, Jacqueline Barlow
Publikováno v:
eLife, Vol 11 (2022)
Class switch recombination generates distinct antibody isotypes critical to a robust adaptive immune system, and defects are associated with autoimmune disorders and lymphomagenesis. Transcription is required during class switch recombination to recr
Externí odkaz:
https://doaj.org/article/1cc4de19daa34fbdb2ea820c6df9b779
Autor:
Célia Alecki, Victoria Chiwara, Lionel A. Sanz, Daniel Grau, Osvaldo Arias Pérez, Elodie L. Boulier, Karim-Jean Armache, Frédéric Chédin, Nicole J. Francis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
RNA is implicated in the targeting and function of Polycomb Group (PcG) chromatin regulators. Here the authors show that R-loops, three-stranded nucleic acid structures formed by DNA and RNA, are formed at some PcG binding sites in flies, as they are
Externí odkaz:
https://doaj.org/article/67fff55423e64e0eb9a287213bb9999c
Publikováno v:
eLife, Vol 9 (2020)
Displacement loops (D-loops) are signature intermediates formed during homologous recombination. Numerous factors regulate D-loop formation and disruption, thereby influencing crucial aspects of DNA repair, including donor choice and the possibility
Externí odkaz:
https://doaj.org/article/0b49950c133f4c2382f5323ebaf1c5a8
Autor:
Shanaya Shital Shah, Stella Hartono, Aurèle Piazza, Vanessa Som, William Wright, Frédéric Chédin, Wolf-Dietrich Heyer
Publikováno v:
eLife, Vol 9 (2020)
Displacement loops (D-loops) are critical intermediates formed during homologous recombination. Rdh54 (a.k.a. Tid1), a Rad54 paralog in Saccharomyces cerevisiae, is well-known for its role with Dmc1 recombinase during meiotic recombination. Yet contr
Externí odkaz:
https://doaj.org/article/b733ef15e04c47d69371f47d2ccc9a96
Autor:
Shira Sagie, Shir Toubiana, Stella R. Hartono, Hagar Katzir, Aya Tzur-Gilat, Shany Havazelet, Claire Francastel, Guillaume Velasco, Frédéric Chédin, Sara Selig
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
ICF syndrome cells exhibit shortened telomeres and elevated levels of the noncoding RNA TERRA. Here the authors show this is associated with high levels of DNA damage, suggesting an increase in telomere dysfunction due to the formation of DNA: RNA hy
Externí odkaz:
https://doaj.org/article/a6ea7685f09c4013935240ad88a3e9f7
Autor:
Caroline Townsend Stork, Michael Bocek, Madzia P Crossley, Julie Sollier, Lionel A Sanz, Frédéric Chédin, Tomek Swigut, Karlene A Cimprich
Publikováno v:
eLife, Vol 5 (2016)
The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 s
Externí odkaz:
https://doaj.org/article/2a1e17c1ffb44c1cb044d013ec1a87a2
Publikováno v:
eLife, Vol 4 (2015)
Aicardi–Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE). AGS is thought to arise from the accumulation of incompletely metabolized endogenous nucl
Externí odkaz:
https://doaj.org/article/dbafbfed16254558851d360809c83863
Publikováno v:
PLoS Genetics, Vol 10, Iss 4, p e1004294 (2014)
Expansion of a trinucleotide (CGG) repeat element within the 5' untranslated region (5'UTR) of the human FMR1 gene is responsible for a number of heritable disorders operating through distinct pathogenic mechanisms: gene silencing for fragile X syndr
Externí odkaz:
https://doaj.org/article/8220904b9ebe4dd79e479e007dbfc502
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78752 (2013)
DNA methyltransferase 1 (DNMT1) is the enzyme most responsible for epigenetic modification of human DNA and the intended target of approved cancer drugs such as 5-aza-cytidine and 5-aza-2'-deoxycytidine. 5-aza nucleosides have complex mechanisms of a
Externí odkaz:
https://doaj.org/article/ec32c8c2e7654dcdb3cf87d705aa021b