Gene prioritization based on random walks with restarts and absorbing states, to define gene sets regulating drug pharmacodynamics from single-cell analyses.

Autor: Augusto Sales de Queiroz, Guilherme Sales Santa Cruz, Alain Jean-Marie, Dorian Mazauric, Jérémie Roux, Frédéric Cazals

Publikováno v: PLoS ONE, Vol 17, Iss 11, p e0268956 (2022)

Prioritizing genes for their role in drug sensitivity, is an important step in understanding drugs mechanisms of action and discovering new molecular targets for co-treatment. To formalize this problem, we consider two sets of genes X and P respectiv

Externí odkaz: https://doaj.org/article/8b9205bdc6f44d73b55619f2ed0a463d

Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection.

Autor: Rosario Castro, Luc Jouneau, Hang-Phuong Pham, Olivier Bouchez, Véronique Giudicelli, Marie-Paule Lefranc, Edwige Quillet, Abdenour Benmansour, Frédéric Cazals, Adrien Six, Simon Fillatreau, Oriol Sunyer, Pierre Boudinot

Publikováno v: PLoS Pathogens, Vol 9, Iss 1, p e1003098 (2013)

Upon infection, B-lymphocytes expressing antibodies specific for the intruding pathogen develop clonal responses triggered by pathogen recognition via the B-cell receptor. The constant region of antibodies produced by such responding clones dictates

Externí odkaz: https://doaj.org/article/7be38ef00475454db7f8e1a913d761bf

Geometric constraints within tripeptides and the existence of tripeptide reconstructions

Autor: Timothée O'Donnell, Viraj Agashe, Frédéric Cazals

Publikováno v: Journal of Computational Chemistry
Journal of Computational Chemistry, In press, ⟨10.1101/2022.06.21.497005⟩

Designing movesets providing high quality protein conformations remains a hard problem, especially when it comes to deform a long protein backbone segment, and a key building block to do so is the so-called tripeptide loop closure (TLC). Consider a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a895a7273f590a6c53275977b7336e
https://inria.hal.science/hal-03917931

Boosting the analysis of protein interfaces with Multiple Interface String Alignments: illustration on the spikes of coronaviruses

Autor: Stéphane Bereux, Frédéric Cazals, Bernard Delmas

Publikováno v: Proteins-Structure, Function and Bioinformatics
Proteins-Structure, Function and Bioinformatics, Wiley, In press
Proteins-Structure, Function and Bioinformatics, 2022, 90 (3), pp.848-857. ⟨10.1002/prot.26279⟩

We introduce Multiple Interface String Alignment (MISA), a visualization tool to display coherently various sequence and structure based statistics at protein-protein interfaces (SSE elements, buried surface area, ΔASA, B factor values, etc). The am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658fb9ab4a2e805d695e2ea026a66444
https://hal.inria.fr/hal-03387889/document

Gene prioritization based on random walks with restarts and absorbing states, to define gene sets regulating drug pharmacodynamics from single-cell analyses

Autor: Jérémie Roux, Alain Jean-Marie, Guilherme Sales Santa Cruz, Augusto Sales-De-Queiroz, Dorian Mazauric, Frédéric Cazals

Publikováno v: PLoS ONE
PLoS ONE, 2022, 17 (11), pp.e0268956. ⟨10.1371/journal.pone.0268956⟩

Prioritizing genes for their role in drug sensitivity, is an important step in understanding drugs mechanisms of action and discovering new molecular targets for co-treatment. To formalize this problem, we consider two sets of genes X and P respectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe25dabd5031eb8f89a51625b5a2da5
https://pubmed.ncbi.nlm.nih.gov/36342924