Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Frédéric Berst"'
1
Akademický článek
Diversity-oriented synthesis encoded by deoxyoligonucleotides
Autor: Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of
Externí odkaz: https://doaj.org/article/36c9d05209eb47b1b03cc9fce00df87d
Zobrazit plný text záznamu
3
Rational screening for cooperativity in small-molecule inducers of protein–protein associations
Autor: Shuang Liu, Bingqi Tong, Jeremy W. Mason, Jonathan M. Ostrem, Antonin Tutter, Bruce K. Hua, Sunny A. Tang, Simone Bonazzi, Karin Briner, Frédéric Berst, Frédéric J. Zécri, Stuart L. Schreiber
Publikováno v: bioRxiv
The hallmark of a molecular glue is its ability to induce cooperative protein–protein interactions, leading to the formation of a ternary complex, despite weaker binding towards one or both individual proteins. Notably, the extent of cooperativity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf3ad108fb04b6c68686d086e12b440
https://europepmc.org/articles/PMC10245867/
Zobrazit plný text záznamu
4
DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules
Autor: Jeremy W. Mason, Liam Hudson, Matthias V. Westphal, Antonin Tutter, Gregory Michaud, Wei Shu, Xiaolei Ma, Connor W. Coley, Paul A. Clemons, Simone Bonazzi, Frédéric Berst, Frédéric J. Zécri, Karin Briner, Stuart L. Schreiber
Molecular glues and bifunctional compounds that induce protein–protein associations provide a powerful and general mechanism to modulate cell circuitry. We sought to develop a platform for the direct discovery of compounds able to induce associatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::353823b77fa8f321be337dcdf45df150
https://doi.org/10.1101/2022.10.13.512184
Zobrazit plný text záznamu
6
The development and preparation of the 2,4-dimethoxybenzyl arylhydrazine (DMBAH) 'latent' safety-catch linker: solid phase synthesis of ketopiperazines
Autor: Mark Ladlow, Andrew B. Holmes, Frédéric Berst
Publikováno v: Org. Biomol. Chem.. 1:1711-1719
The development and preparation of the 2,4-dimethoxybenzyl arylhydrazine (DMBAH) linker 3, a new class of “latent” safety-catch linker which is stable under Mitsunobu alkylation conditions and in the presence of amines and hydrazine, is reported.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf99b7329b13219dd1c6f438117ed5c5
https://doi.org/10.1039/b301701j
Zobrazit plný text záznamu
7
The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin
Autor: Peter W. Seale, Peter John Murray, Andrew B. Holmes, Mark Ladlow, Frédéric Berst, Simon L. Croft, Richard J. Upton, Paul Stead, Albert Andrzej Glaxo Wellcome plc Jaxa-Chamiec, William Clegg, Michael Kranz, Kenneth Keavey, Stephen Taylor, Mark R. J. Elsegood
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:773-776
A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd8d1793a0c281c4d686a6ae3e11cd3
https://doi.org/10.1016/s0960-894x(01)00049-x
Zobrazit plný text záznamu
8
A latent aryl hydrazine ‘safety-catch’ linker compatible with N-alkylation
Autor: Mark Ladlow, Andrew B. Holmes, Frédéric Berst, Peter John Murray
Publikováno v: Tetrahedron Letters. 41:6649-6653
The preparation and use of a latent aryl hydrazine ‘safety-catch’ linker for solid-phase chemistry, which is compatible with N-alkylation, is reported. Its use is exemplified by the preparation of mono-ketopiperazines, whereby release from resin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e42f03f20891c6e162b330fb55902c8
https://doi.org/10.1016/s0040-4039(00)01108-4
Zobrazit plný text záznamu
9
Solid-phase synthesis of apicidin A and a cyclic tetrapeptoid analogue
Autor: Andrew B. Holmes, Mark Ladlow, Frédéric Berst
Publikováno v: Chemical communications (Cambridge, England). (5)
The solid-phase synthesis of the antiprotozoal cyclic tetrapeptide apicidin A is reported and its synthetic accessibility is contrasted with that of a structurally similar reduced cyclic tetrapeptoid analogue.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b037ceee82ae8aa64526f22c1a74907
https://pubmed.ncbi.nlm.nih.gov/12120564
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje