Výsledky vyhledávání - "Frédéric Baudat"

Akademický článek

FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading

Autor: Akbar Zainu, Pauline Dupaigne, Soumya Bouchouika, Julien Cau, Julie A. J. Clément, Pauline Auffret, Virginie Ropars, Jean-Baptiste Charbonnier, Bernard de Massy, Raphael Mercier, Rajeev Kumar, Frédéric Baudat

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1 are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by homologous recombination (HR). A balanced activity of positive and negative R

Externí odkaz: https://doaj.org/article/b23ba1e45f564ac9871d10aea2621def

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Akademický článek

Genomic architecture of endogenous ichnoviruses reveals distinct evolutionary pathways leading to virus domestication in parasitic wasps

Autor: Fabrice Legeai, Bernardo F. Santos, Stéphanie Robin, Anthony Bretaudeau, Rebecca B. Dikow, Claire Lemaitre, Véronique Jouan, Marc Ravallec, Jean-Michel Drezen, Denis Tagu, Frédéric Baudat, Gabor Gyapay, Xin Zhou, Shanlin Liu, Bruce A. Webb, Seán G. Brady, Anne-Nathalie Volkoff

Publikováno v: BMC Biology, Vol 18, Iss 1, Pp 1-23 (2020)

Abstract Background Polydnaviruses (PDVs) are mutualistic endogenous viruses inoculated by some lineages of parasitoid wasps into their hosts, where they facilitate successful wasp development. PDVs include the ichnoviruses and bracoviruses that orig

Externí odkaz: https://doaj.org/article/c3118a6fc30e4dfdad3101c63c5b2dd6

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Akademický článek

PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

Autor: Yukiko Imai, Mathilde Biot, Julie AJ Clément, Mariko Teragaki, Serge Urbach, Thomas Robert, Frédéric Baudat, Corinne Grey, Bernard de Massy

Publikováno v: eLife, Vol 9 (2020)

Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation are unknown. Using proteomic ap

Externí odkaz: https://doaj.org/article/854848377549491da558312ea21dbe9c

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The FIGNL1-FIRRM complex is required to complete meiotic recombination in the mouse and prevents massive DNA damage-independent RAD51 and DMC1 loading

Autor: Akbar Zainu, Pauline Dupaigne, Soumya Bouchouika, Julien Cau, Julie A. J. Clément, Pauline Auffret, Virginie Ropars, Jean-Baptiste Charbonnier, Bernard de Massy, Rajeev Kumar, Frédéric Baudat

During meiosis, nucleoprotein filaments of the strand exchange proteins RAD51 and DMC1 are crucial for repairing SPO11-generated DNA double-strand breaks (DSBs) by homologous recombination (HR). A balanced activity of positive and negative RAD51/DMC1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93ab84a7b016f89a60e516b68837e102
https://doi.org/10.1101/2023.05.17.541096

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Akademický článek

PRDM9, a driver of the genetic map.

Autor: Corinne Grey, Frédéric Baudat, Bernard de Massy

Publikováno v: PLoS Genetics, Vol 14, Iss 8, p e1007479 (2018)

During meiosis, maternal and paternal chromosomes undergo exchanges by homologous recombination. This is essential for fertility and contributes to genome evolution. In many eukaryotes, sites of meiotic recombination, also called hotspots, are region

Externí odkaz: https://doaj.org/article/3e426d5e45f94d1f986c4c7eaebb8b04

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Akademický článek

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9

Autor: Hong Wu, Nikolas Mathioudakis, Boubou Diagouraga, Aiping Dong, Ludmila Dombrovski, Frédéric Baudat, Stephen Cusack, Bernard de Massy, Jan Kadlec

Publikováno v: Cell Reports, Vol 5, Iss 1, Pp 13-20 (2013)

PRDM9, a histone lysine methyltransferase, is a key determinant of the localization of meiotic recombination hot spots in humans and mice and the only vertebrate protein known to be involved in hybrid sterility. Here, we report the crystal structure

Externí odkaz: https://doaj.org/article/441a5c8c07ee4339885fc3874938ebc6

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Sex chromosome quadrivalents in oocytes of the African pygmy mouse Mus minutoides that harbors non-conventional sex chromosomes

Autor: Bernard de Massy, Frédéric Baudat, Frédéric Veyrunes

Publikováno v: Chromosoma
Chromosoma, 2019, 128 (3), pp.397-411. ⟨10.1007/s00412-019-00699-4⟩
Chromosoma, Springer Verlag, 2019, 128 (3), pp.397-411. ⟨10.1007/s00412-019-00699-4⟩

International audience; Eutherian mammals have an extremely conserved sex-determining system controlled by highly differentiated sex chromosomes. Females are XX and males XY, and any deviation generally leads to infertility, mainly due to meiosis dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1d33af9dc9c369ef2e5d68e9b322bf
https://doi.org/10.1007/s00412-019-00699-4

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Genomic architecture of endogenous ichnoviruses reveals distinct evolutionary pathways leading to virus domestication in parasitic wasps

Autor: Gabor Gyapay, Claire Lemaitre, Seán G. Brady, Frédéric Baudat, Denis Tagu, Anne-Nathalie Volkoff, Fabrice Legeai, Anthony Bretaudeau, Rebecca B. Dikow, Xin Zhou, Marc Ravallec, Stéphanie Robin, Jean-Michel Drezen, Bernardo F. Santos, Shanlin Liu, Véronique Jouan, Bruce A. Webb

Publikováno v: BMC Biology
BMC Biology, 2020, 18 (1), pp.1-23. ⟨10.1186/s12915-020-00822-3⟩
BMC Biology, BioMed Central, 2020, 18 (1), pp.1-23. ⟨10.1186/s12915-020-00822-3⟩
BMC Biology, Vol 18, Iss 1, Pp 1-23 (2020)

Background Polydnaviruses (PDVs) are mutualistic endogenous viruses inoculated by some lineages of parasitoid wasps into their hosts, where they facilitate successful wasp development. PDVs include the ichnoviruses and bracoviruses that originate fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1299a721804d552886f3de0ebbb6874d
https://hal.inrae.fr/hal-02918230

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PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment

Autor: Mariko Teragaki, Julie A. J. Clément, Serge Urbach, Corinne Grey, Yukiko Imai, Mathilde Biot, Thomas Robert, Frédéric Baudat, Bernard de Massy

Publikováno v: eLife
eLife, Vol 9 (2020)
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.57117⟩
eLife, eLife Sciences Publication, 2020, 9, pp.e57117. ⟨10.7554/eLife.57117⟩
eLife, 2020, 9, pp.e57117. ⟨10.7554/elife.57117⟩

International audience; Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation are unk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8faf3f9d1501d61faba908f3bcc01a8
https://pubmed.ncbi.nlm.nih.gov/33047671

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Akademický článek

Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.

Autor: Petr Flachs, Ondřej Mihola, Petr Simeček, Soňa Gregorová, John C Schimenti, Yasuhisa Matsui, Frédéric Baudat, Bernard de Massy, Jaroslav Piálek, Jiří Forejt, Zdenek Trachtulec

Publikováno v: PLoS Genetics, Vol 8, Iss 11, p e1003044 (2012)

The Dobzhansky-Muller model of incompatibilities explains reproductive isolation between species by incorrect epistatic interactions. Although the mechanisms of speciation are of great interest, no incompatibility has been characterized at the gene l

Externí odkaz: https://doaj.org/article/37c688b497cd41a4b268bbff67848644

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