Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Frédéric Donche"'
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ff65b82b2e1feff6acc28b9dcac4dc
https://doi.org/10.1021/acs.jmedchem.9b00318
https://doi.org/10.1021/acs.jmedchem.9b00318
Autor:
Hervé Coste, Marie-Hélène Fouchet, Frédéric Donche, Sylvie Demaria Magny, Florent Potvain, M Walker, Marc Issandou, Nerina Dodic, Anne-Benedicte Boullay, Anne Marie Jeanne Bouillot, Christophe Junot, Christelle Martin
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6218-6232
We describe the discovery of novel potent inhibitors of 2,3-oxidosqualene:lanosterol cyclase inhibitors (OSCi) from a focused pharmacophore-based screen. Optimization of the most tractable hits gave a series of compounds showing inhibition of cholest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cc548326435712eff6b2fe670048ac
https://doi.org/10.1016/j.bmc.2008.04.034
https://doi.org/10.1016/j.bmc.2008.04.034
Autor:
Jean-Marie Brusq, Pascal Grondin, Benjamin Beaufils, Frédéric Donche, Stéphane Sautet, Celine Marques, Edwige Nicodeme, Yann Dudit, Catherine-Anne Clément, Pascal Huet, Yannick Saintillan, Eric Boursier, Jérôme Toum, Mathieu Pizzonero, Emilie Rondet, Lionel Trottet, Olivier Mirguet
AMP-activated protein kinase (AMPK) is an evolutionarily conserved fuel-sensing enzyme that is activated in shortage of energy and suppressed in its surfeit. AMPK activation stimulates fatty acid oxidation, enhances insulin sensitivity, alleviates hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8260bf96114fc481fec9048186ad6416
https://europepmc.org/articles/PMC4027520/
https://europepmc.org/articles/PMC4027520/
Autor:
Anne Marie Jeanne Bouillot, Frédéric Donche, Olivier Mirguet, Rab K. Prinjha, Gael Krysa, Edwige Nicodeme, Ann Louise Walker, Chun-wa Chung, Laurie J. Gordon, Kevin Lee, Soren Beinke, David Matthew Wilson, Inma Rioja, Toni Lewis, Leanne Cutler, Dave Lugo, Jonathan Thomas Seal, Jason Witherington, Paul Bamborough, Yann Lamotte, Scott McCleary, Jorge Kirilovsky, Françoise Gellibert
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(8)
A novel series of quinoline isoxazole BET family bromodomain inhibitors are discussed. Crystallography is used to illustrate binding modes and rationalize their SAR. One member, I-BET151 (GSK1210151A), shows good oral bioavailability in both the rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efda9004d594274ddcec17c62b1aae4d
https://pubmed.ncbi.nlm.nih.gov/22437115
https://pubmed.ncbi.nlm.nih.gov/22437115
Autor:
Delphine Delannée, Agnès Costaz, Jonathan Thomas Seal, Lionel Trottet, Rémi Tellier, Jean-Marie Brusq, Olivier Mirguet, Anne Marie Jeanne Bouillot, Sandrine Martin, Gael Krysa, Anne-Benedicte Boullay, Jorge Kirilovsky, Eric Boursier, Jérôme Toum, Yann Dudit, Van-Loc Nguyen, Edwige Nicodeme, Françoise Gellibert, Alizon M. Riou, Pascal Huet, Romain Luc Marie Gosmini, Yann Lamotte, Florence Blandel, Frédéric Donche
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(8)
The discovery, synthesis and biological evaluation of a novel series of 7-isoxazoloquinolines is described. Several analogs are shown to increase ApoA1 expression within the nanomolar range in the human hepatic cell line HepG2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30974817f673615f23351a44033e69cf
https://pubmed.ncbi.nlm.nih.gov/22386529
https://pubmed.ncbi.nlm.nih.gov/22386529
Autor:
Michael L. Sierra, Véronique Beneton, Anne-Bénédict Boullay, Thierry Boyer, Andrew G. Brewster, Frédéric Donche, Marie-Claire Forest, Marie-Hélène Fouchet, Françoise J. Gellibert, Didier A. Grillot, Millard H. Lambert, Alain Laroze, Christelle Le Grumelec, Jean Michel Linget, Valerie G. Montana, Van-Loc Nguyen, Edwige Nicodème, Vipul Patel, Annie Penfornis, Olivier Pineau
Publikováno v:
Journal of Medicinal Chemistry; Feb2007, Vol. 50 Issue 4, p685-695, 11p