Rck of Salmonella Typhimurium Delays the Host Cell Cycle to Facilitate Bacterial Invasion

Autor: Julien Mambu, Emilie Barilleau, Laetitia Fragnet-Trapp, Yves Le Vern, Michel Olivier, Guillaume Sadrin, Olivier Grépinet, Frédéric Taieb, Philippe Velge, Agnès Wiedemann

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

Salmonella Typhimurium expresses on its outer membrane the protein Rck which interacts with the epidermal growth factor receptor (EGFR) of the plasma membrane of the targeted host cells. This interaction activates signaling pathways, leading to the i

Externí odkaz: https://doaj.org/article/8252f38f0152493bbd77615ee8925adf

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

Autor: Nadège Bossuet-Greif, Julien Vignard, Frédéric Taieb, Gladys Mirey, Damien Dubois, Claude Petit, Eric Oswald, Jean-Philippe Nougayrède

Publikováno v: mBio, Vol 9, Iss 2 (2018)

ABSTRACT Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island. These genotoxic metabolites are produced by pks-encoded peptide-polyk

Externí odkaz: https://doaj.org/article/2f0d926a50d440af8b39cd1eca2c38c9

Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections

Autor: Rachid A. El-Aouar Filho, Aurélie Nicolas, Thiago L. De Paula Castro, Martine Deplanche, Vasco A. De Carvalho Azevedo, Pierre L. Goossens, Frédéric Taieb, Gerard Lina, Yves Le Loir, Nadia Berkova

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion. Pathogenic bacteria produce multiple compounds that generate favora

Externí odkaz: https://doaj.org/article/032184e14e934139b830afce5dfade1b

Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells

Autor: Eric Oswald, Frédéric Taieb, Jean-Philippe Nougayrède

Publikováno v: Toxins, Vol 3, Iss 4, Pp 356-368 (2011)

Cycle inhibiting factors (Cifs) are type III secreted effectors produced by diverse pathogenic bacteria. Cifs are “cyclomodulins” that inhibit the eukaryotic host cell cycle and also hijack other key cellular processes such as those controlling t

Externí odkaz: https://doaj.org/article/7e078cb4272c4d9ca87cd92f715240a0

Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response

Autor: Claire Naylies, Gladys Mirey, Patrick Rouimi, Benoît J. Pons, Maxime Deslande, Saleha Hashim, Julien Vignard, Catherine Bouchenot, Yannick Lippi, Frédéric Taieb, Aurélie Pettes-Duler

Publikováno v: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2021, ⟨10.1007/s00018-021-03902-x⟩
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (17-18), pp.6319-6335. ⟨10.1007/s00018-021-03902-x⟩
Cellular and Molecular Life Sciences, 2021, 78 (17-18), pp.6319-6335. ⟨10.1007/s00018-021-03902-x⟩

The Cytolethal Distending Toxin (CDT) is a bacterial genotoxin produced by pathogenic bacteria causing major foodborne diseases worldwide. CDT activates the DNA Damage Response and modulates the host immune response, but the precise relationship betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12bbce2c9f7c168e88e1125faac9d14
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03328013