Imidazoquinoline Derivatives as Potential Inhibitors of InhA Enzyme and Mycobacterium tuberculosis

Autor: Pascal Hoffmann, Joëlle Azéma-Despeyroux, Fernanda Goncalves, Alessandro Stamilla, Nathalie Saffon-Merceron, Frédéric Rodriguez, Giulia Degiacomi, Maria Rosalia Pasca, Christian Lherbet

Publikováno v: Molecules, Vol 29, Iss 13, p 3076 (2024)

Tuberculosis is a serious public health problem worldwide. The search for new antibiotics has become a priority, especially with the emergence of resistant strains. A new family of imidazoquinoline derivatives, structurally analogous to triazolophtha

Externí odkaz: https://doaj.org/article/2c1ad0e2eed648a4ab889c946f63fcb2

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

Autor: Cécile Baudoin-Dehoux, Tessa Castellan, Frédéric Rodriguez, Arnaud Rives, Fabien Stauffert, Virginie Garcia, Thierry Levade, Philippe Compain, Yves Génisson

Publikováno v: Molecules, Vol 24, Iss 2, p 354 (2019)

A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion. This study illustrated how a

Externí odkaz: https://doaj.org/article/e927eba948964c89b70d37f9bf64d369

Isolation and identification of ten new sildenafil derivatives in an alleged herbal supplement for sexual enhancement

Autor: Isabelle Fabing, Frédéric Rodriguez, Gaëtan Assemat, Robert Martino, Véronique Gilard, Myriam Malet-Martino, Stéphane Balayssac, Yves Génisson, Nathalie Martins-Froment

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2020, 191, pp.113482. ⟨10.1016/j.jpba.2020.113482⟩
Journal of Pharmaceutical and Biomedical Analysis, 2020, 191, pp.113482. ⟨10.1016/j.jpba.2020.113482⟩

International audience; A sexual enhancer dietary supplement in pre-commercialization phase was analyzed. It 18 contained the two phosphodiesterase-5 inhibitors (PDE-5i) sildenafil and methisosildenafil as 19 major adulterants. Fourteen more sildenaf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa2455b1cb204f047c5eddf0a11d956
https://hal.archives-ouvertes.fr/hal-02966885/document

N,O-Dialkyl deoxynojirimycin derivatives as CERT START domain ligands

Autor: Frédéric Rodriguez, Mathieu L. Lepage, Philippe Compain, Tessa Castellan, Cécile Santos, Yves Génisson, Cécile Dehoux, Anne Bodlenner, Yan Liang, Stéphanie Ballereau

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2020, pp.126796. ⟨10.1016/j.bmcl.2019.126796⟩
Bioorganic and Medicinal Chemistry Letters, 2020, pp.126796. ⟨10.1016/j.bmcl.2019.126796⟩

Dysregulation of the ceramide transport protein CERT is associated to diseases such as cancer. In search for new CERT START domain ligands, N-dodecyl-deoxynojirimycin (N-dodecyl-DNJ) iminosugar was found to display, as a ceramide mimic, significant p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4160a4e1ef4ded8c10d8b76f969afb8
https://hal.archives-ouvertes.fr/hal-02362770/file/BMCL-DNJ.pdf

Pares y redes de laboratorios del Centre National de la Recherche Scientifique y de sus asociados

Autor: Marie-Pierre Bès, Adrien Defossez, Frédéric Rodriguez

Publikováno v: REDES: Revista Hispana para el Análisis de Redes Sociales, Vol 19, Iss 2 (2010)

El siguiente artículo arroja luz sobre el tema de la organización "irreversible" de las alianzas de investigación, a partir de datos longitudinales relativos a los contratos firmados por grupos de investigación del Centre National de la Recherche

Externí odkaz: https://doaj.org/article/21731f3594724cc4bb745cb07ac84cdb