Zobrazeno 1 - 10 of 239 pro vyhledávání: '"Frédéric, Lamaty"'
1
Akademický článek
Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame.
Autor: Dr. Tharwat Mohy El‐Dine, Matthieu Lavayssiere, Dr. Hélène Adihou, Prof. Gilles Subra, Dr. Thomas‐Xavier Métro, Dr. Olivier Ludemann‐Hombourger, Dr. Frédéric Lamaty
Publikováno v: ChemistryEurope, Vol 2, Iss 3-4, Pp n/a-n/a (2024)
Abstract The solventless synthesis of peptides from unactivated amino acids was optimized in a twin‐screw extruder (TSE). The general method enabled the preparation of dipeptides and tripeptides with no epimerization. This flow mechanochemistry app
Externí odkaz: https://doaj.org/article/a0586154c9b746baa52026f88bcb14df
Zobrazit plný text záznamu
2
Akademický článek
The Constitutive Activity of Spinal 5-HT6 Receptors Contributes to Diabetic Neuropathic Pain in Rats
Autor: Nazarine Mokhtar, Marcin Drop, Florian Jacquot, Sylvain Lamoine, Eric Chapuy, Laetitia Prival, Youssef Aissouni, Vittorio Canale, Frédéric Lamaty, Paweł Zajdel, Philippe Marin, Stéphane Doly, Christine Courteix
Publikováno v: Biomolecules, Vol 13, Iss 2, p 364 (2023)
Diabetic neuropathy is often associated with chronic pain. Serotonin type 6 (5-HT6) receptor ligands, particularly inverse agonists, have strong analgesic potential and may be new candidates for treating diabetic neuropathic pain and associated co-mo
Externí odkaz: https://doaj.org/article/daf7a7ff471b454c903b013b316013ce
Zobrazit plný text záznamu
3
Akademický článek
Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT6 and D3R Affinity in the 1H-Pyrrolo[3,2-c]quinoline Series
Autor: Katarzyna Grychowska, Wojciech Pietruś, Ludmiła Kulawik, Ophélie Bento, Grzegorz Satała, Xavier Bantreil, Frédéric Lamaty, Andrzej J. Bojarski, Joanna Gołębiowska, Agnieszka Nikiforuk, Philippe Marin, Séverine Chaumont-Dubel, Rafał Kurczab, Paweł Zajdel
Publikováno v: Molecules, Vol 28, Iss 3, p 1096 (2023)
Salt bridge (SB, double-charge-assisted hydrogen bonds) formation is one of the strongest molecular non-covalent interactions in biological systems, including ligand–receptor complexes. In the case of G-protein-coupled receptors, such an interactio
Externí odkaz: https://doaj.org/article/813c1b8b56594a4e9a7cc04e5eb520b2
Zobrazit plný text záznamu
4
Akademický článek
1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT6R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity
Autor: Vittorio Canale, Wojciech Trybała, Séverine Chaumont-Dubel, Paulina Koczurkiewicz-Adamczyk, Grzegorz Satała, Ophélie Bento, Klaudia Blicharz-Futera, Xavier Bantreil, Elżbieta Pękala, Andrzej J. Bojarski, Frédéric Lamaty, Philippe Marin, Paweł Zajdel
Publikováno v: Biomolecules, Vol 13, Iss 1, p 12 (2022)
In addition to the canonical Gs adenylyl cyclase pathway, the serotonin type 6 receptor (5-HT6R) recruits additional signaling pathways that control cognitive function, brain development, and synaptic plasticity in an agonist-dependent and independen
Externí odkaz: https://doaj.org/article/359b495a9fb64b6395f525a0ff337ced
Zobrazit plný text záznamu
6
A mechanochemical approach to the synthesis of sydnones and derivatives
Autor: Xavier Bantreil, Florian Luttringer, Frédéric Lamaty, Nicolas PETRY
Publikováno v: Faraday Discussions. 241:114-127
Sydnones are heterocyclic compounds which display important biological activities, including their abilities to react in 1,3-dipolar additions for applications in the development of new prodrugs. Capitalizing on our preliminary work on the mechanosyn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cd26a73f5d8fd76c6bb72e447dae9e
https://doi.org/10.1039/d2fd00096b
Zobrazit plný text záznamu
7
Akademický článek
Peptide synthesis: ball-milling, in solution, or on solid support, what is the best strategy?
Autor: Ophélie Maurin, Pascal Verdié, Gilles Subra, Frédéric Lamaty, Jean Martinez, Thomas-Xavier Métro
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2087-2093 (2017)
While presenting particularly interesting advantages, peptide synthesis by ball-milling was never compared to the two traditional strategies, namely peptide syntheses in solution and on solid support (solid-phase peptide synthesis, SPPS). In this stu
Externí odkaz: https://doaj.org/article/0ff0404eca6942b69d78c7191e83c684
Zobrazit plný text záznamu
8
Akademický článek
A mechanochemical approach to access the proline–proline diketopiperazine framework
Autor: Nicolas Pétry, Hafid Benakki, Eric Clot, Pascal Retailleau, Farhate Guenoun, Fatima Asserar, Chakib Sekkat, Thomas-Xavier Métro, Jean Martinez, Frédéric Lamaty
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2169-2178 (2017)
Ball milling was exploited to prepare a substituted proline building block by mechanochemical nucleophilic substitution. Subsequently, the mechanocoupling of hindered proline amino acid derivatives was developed to provide proline–proline dipeptide
Externí odkaz: https://doaj.org/article/a390a5ca1e94426dabc138cd31a58e11
Zobrazit plný text záznamu
9
Akademický článek
Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties
Autor: Vittorio Canale, Magdalena Kotańska, Anna Dziubina, Matylda Stefaniak, Agata Siwek, Gabriela Starowicz, Krzysztof Marciniec, Patryk Kasza, Grzegorz Satała, Beata Duszyńska, Xavier Bantreil, Frédéric Lamaty, Marek Bednarski, Jacek Sapa, Paweł Zajdel
Publikováno v: Molecules, Vol 26, Iss 13, p 3828 (2021)
The complex pathophysiology of depression, together with the limits of currently available antidepressants, has resulted in the continuous quest for alternative therapeutic strategies. Numerous findings suggest that pharmacological blockade of α2-ad
Externí odkaz: https://doaj.org/article/3d558fc453414e93aad47bd1aa904ce4
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje