Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Frédéric, Couture"'
Publikováno v:
ACS Omega, Vol 9, Iss 45, Pp 45080-45089 (2024)
Externí odkaz:
https://doaj.org/article/b5f8b11d1c2447cf8f8259530c6cf551
Autor:
Sarah Paris-Robidas, Isabelle Bolduc, Vanessa Lapointe, Julia Galimi, Philippe Lemieux, Carole-Ann Huppé, Frédéric Couture
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Acute respiratory distress syndrome is a severe lung condition resulting from various causes, with life-threatening consequences that necessitate intensive care. The phenomenon can be modeled in preclinical models, notably through the use of
Externí odkaz:
https://doaj.org/article/5ad01dcfbeb34d0d9ac7f8b6062fda46
Autor:
Maud Auger, Luis Sorroza-Martinez, Nadine Brahiti, Carole-Ann Huppé, Laurence Faucher-Giguère, Imen Arbi, Maxime Hervault, Xue Cheng, Bruno Gaillet, Frédéric Couture, David Guay, Al-Halifa Soultan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102290- (2024)
Delivery of antisense oligonucleotides (ASOs) to airway epithelial cells is arduous due to the physiological barriers that protect the lungs and the endosomal entrapment phenomenon, which prevents ASOs from reaching their intracellular targets. Vario
Externí odkaz:
https://doaj.org/article/aa9af6d9fa10459b94b6f48a2b6b7dac
Autor:
Katarina Kulhankova, Soumba Traore, Xue Cheng, Hadrien Benk-Fortin, Stéphanie Hallée, Mario Harvey, Joannie Roberge, Frédéric Couture, Sajeev Kohli, Thomas J. Gross, David K. Meyerholz, Garrett R. Rettig, Bernice Thommandru, Gavin Kurgan, Christine Wohlford-Lenane, Dennis J. Hartigan-O’Connor, Bradley P. Yates, Gregory A. Newby, David R. Liu, Alice F. Tarantal, David Guay, Paul B. McCray
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Gene editing strategies for cystic fibrosis are challenged by the complex barrier properties of airway epithelia. We previously reported that the amphiphilic S10 shuttle peptide non-covalently combined with CRISPR-associated (Cas) ribonucleo
Externí odkaz:
https://doaj.org/article/8ac54f1857804245a0069d9ef38b1f91
Autor:
Nawel Mekdad, Thi Minh Hue Tran, Roxane Desjardins, Anna Kwiatkowska, Frédéric Couture, Robert Day
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Prostate cancer (PCa) is a complex disease progressing from in situ to invasive or metastatic tumors while also being capable of modulating its androgen dependence. Understanding how novel therapies are working across the different stages of
Externí odkaz:
https://doaj.org/article/1a20c45ac946450584feee92fb579f6d
Autor:
Samuel Babity, Shihao Pei, Julia Galimi, Vanessa Lapointe, Davide Brambilla, Frédéric Couture
Publikováno v:
Advanced Sensor Research, Vol 2, Iss 9, Pp n/a-n/a (2023)
Abstract Neutrophils play a key role in the innate immune inflammatory response, notably through the release of the myeloperoxidase enzyme from azurophilic granules, locally generating reactive oxygen species. Although short‐lived, these reactive o
Externí odkaz:
https://doaj.org/article/977180b476df459dbe67ec9b8b000d7d
Autor:
Frédéric Couture, Luojun Wang, Frédérik Dufour, Keena Chabot-Maheux, Nadia Ekindi Ndongo, Robert Sabbagh, Robert Day
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The proprotein convertase PACE4 has demonstrated value as a viable therapeutic target in prostate cancer (PCa). A novel isoform named PACE4-altCT, which arises in neoplastic lesions, plays an important role in tumor progression and has been
Externí odkaz:
https://doaj.org/article/4bdf3b32a1ab49edba94da8b817416f6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Bacteriocins and reuterin are promising antimicrobials for application in food, veterinary, and medical sectors. In the light of their high potential for application in hand sanitizer, we investigated the skin toxicity of reuterin, microcin
Externí odkaz:
https://doaj.org/article/fc020cf9f4974ef09f1797fdbb71abb3
Autor:
Samira Soltani, Frédéric Couture, Yvan Boutin, Laila Ben Said, Samuel Cashman-Kadri, Muriel Subirade, Eric Biron, Ismail Fliss
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 740-746 (2021)
Reuterin (3-hyrdoxypropionaldehyde (3-HPA)) is a highly potent metabolite of L. reuteri, which has applications in food, health, and veterinary sectors. Similar to other natural antimicrobial compounds, the approval of reuterin as a bio-preservative
Externí odkaz:
https://doaj.org/article/b7c031f297aa41fdb545d563b41884e6
Autor:
Samira Soltani, Séverine Zirah, Sylvie Rebuffat, Frédéric Couture, Yvan Boutin, Eric Biron, Muriel Subirade, Ismail Fliss
Publikováno v:
Frontiers in Microbiology, Vol 12 (2022)
Bacteriocins are receiving increased attention as potent candidates in food preservation and medicine. Although the inhibitory activity of bacteriocins has been studied widely, little is known about their gastrointestinal stability and toxicity towar
Externí odkaz:
https://doaj.org/article/7441440936a54977a1fc69d4ada17611