Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Frédéric, Chalmel"'
Autor:
Irinka Séraudie, Catherine Pillet, Beatrice Cesana, Pauline Bazelle, Florian Jeanneret, Bertrand Evrard, Frédéric Chalmel, Assilah Bouzit, Christophe Battail, Jean-Alexandre Long, Jean Luc Descotes, Claude Cochet, Odile Filhol
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-14 (2023)
Abstract Clear cell Renal Cell Carcinoma (ccRCC) is one of the most prevalent kidney cancers, which is often asymptomatic and thus discovered at a metastatic state (mRCC). mRCC are highly heterogeneous tumors composed of subclonal populations that le
Externí odkaz:
https://doaj.org/article/415be9ff2e4f47dc8a8903936a3afc95
Autor:
Louise Ramhøj, Marta Axelstad, Yoni Baert, Ana I. Cañas-Portilla, Frédéric Chalmel, Lars Dahmen, Antonio De La Vieja, Bertrand Evrard, Ann-Cathrin Haigis, Timo Hamers, Kim Heikamp, Henrik Holbech, Patricia Iglesias-Hernandez, Dries Knapen, Lorna Marchandise, Jane E. Morthorst, Nikolai Georgiev Nikolov, Ana C. V. E. Nissen, Michael Oelgeschlaeger, Kostja Renko, Vera Rogiers, Gerrit Schüürmann, Evelyn Stinckens, Mette H. Stub, Monica Torres-Ruiz, Majorie Van Duursen, Tamara Vanhaecke, Lucia Vergauwen, Eva Bay Wedebye, Terje Svingen
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Current test strategies to identify thyroid hormone (TH) system disruptors are inadequate for conducting robust chemical risk assessment required for regulation. The tests rely heavily on histopathological changes in rodent thyroid glands or measurin
Externí odkaz:
https://doaj.org/article/11318ef2537f459fb447b21949bc2674
Autor:
Ludovic Dumont, Hélène Lopez Maestre, Frédéric Chalmel, Louise Huber, Aurélie Rives-Feraille, Laura Moutard, Frédérique Bateux, Christine Rondanino, Nathalie Rives
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionSuitable cryopreservation procedures of pre-pubertal testicular tissue associated with efficient culture conditions are crucial in the fields of fertility preservation and restoration. In vitro spermatogenesis remains a challenging techni
Externí odkaz:
https://doaj.org/article/8a89651f2168499e9a238e569a1c0310
Autor:
Soazik P. Jamin, Feria Hikmet, Romain Mathieu, Bernard Jégou, Cecilia Lindskog, Frédéric Chalmel, Michael Primig
Publikováno v:
Molecular Oncology, Vol 15, Iss 11, Pp 3003-3023 (2021)
Cancer/Testis (CT) genes are induced in germ cells, repressed in somatic cells, and derepressed in somatic tumors, where these genes can contribute to cancer progression. CT gene identification requires data obtained using standardized protocols and
Externí odkaz:
https://doaj.org/article/dc5a09e0471843029402344e665b323c
Autor:
Anna Keppner, Miguel Correia, Sara Santambrogio, Teng Wei Koay, Darko Maric, Carina Osterhof, Denise V Winter, Angèle Clerc, Michael Stumpe, Frédéric Chalmel, Sylvia Dewilde, Alex Odermatt, Dieter Kressler, Thomas Hankeln, Roland H Wenger, David Hoogewijs
Publikováno v:
eLife, Vol 11 (2022)
Spermatogenesis is a highly specialized differentiation process driven by a dynamic gene expression program and ending with the production of mature spermatozoa. Whereas hundreds of genes are known to be essential for male germline proliferation and
Externí odkaz:
https://doaj.org/article/e692440467a1446e9f1f94e8b46fc3c1
Autor:
Barbara Nicol, Sara A. Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H.-C. Yao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Proper ovarian differentiation requires RUNX1. Here, the authors show that double knockout of Runx1/Foxl2 results in masculinization of fetal ovaries, and that RUNX1 and FOXL2 jointly occupy common chromatin regions to maintain pre-granulosa cell ide
Externí odkaz:
https://doaj.org/article/70611c2bdf5d4776a09548dc9ccd8240
Autor:
Justine Saulnier, Frédéric Chalmel, Marion Delessard, Laura Moutard, Tony Pereira, François Fraissinet, Ludovic Dumont, Aurélie Rives-Feraille, Christine Rondanino, Nathalie Rives
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5893 (2022)
In vitro spermatogenesis appears to be a promising approach to restore the fertility of childhood cancer survivors. The rat model has proven to be challenging, since germ cell maturation is arrested in organotypic cultures. Here, we report that, desp
Externí odkaz:
https://doaj.org/article/e6ba0f13021a4d96a1e946b437abd965
Autor:
Judikael R. Saout, Gwendoline Lecuyer, Simon Léonard, Bertrand Evrard, Solène-Florence Kammerer-Jacquet, Laurence Noël, Zine-Eddine Khene, Romain Mathieu, Angélique Brunot, Antoine D. Rolland, Karim Bensalah, Nathalie Rioux-Leclercq, Aurélie Lardenois, Frédéric Chalmel
Publikováno v:
European Urology
European Urology, 2023, 83 (5), pp.441-451. ⟨10.1016/j.eururo.2023.02.008⟩
European Urology, 2023, 83 (5), pp.441-451. ⟨10.1016/j.eururo.2023.02.008⟩
International audience; BACKGROUND: Intratumor heterogeneity (ITH) is a key feature in clear cell renal cell carcinomas (ccRCCs) that impacts outcomes such as aggressiveness, response to treatments, or recurrence. In particular, it may explain tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d34991202c07fdb93e947a280ca9bf
https://hal.science/hal-04094522/document
https://hal.science/hal-04094522/document
Autor:
Sirine Souali-Crespo, Diana Condrea, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Erwan Grandgirard, Violaine Alunni, Marie Cerciat, Matthieu Jung, Chloé Mayere, Serge Nef, Manuel Mark, Frédéric Chalmel, Norbert B. Ghyselinck
NR5A1 is an orphan nuclear receptor crucial for gonadal development in mammals. In the mouse testis it is expressed both in Sertoli cells (SC) and Leydig cells (LC). To investigate its role posteriorly to sex determination, we have generated and anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf06edd781be6fc7178f14af62417390
https://doi.org/10.1101/2023.01.04.522755
https://doi.org/10.1101/2023.01.04.522755
Autor:
Indusha Kugathas, Hanna K. L. Johansson, Edith Chan Sock Peng, Maryne Toupin, Bertrand Evrard, Thomas A. Darde, Julie Boberg, Monica K. Draskau, Antoine D. Rolland, Séverine Mazaud-Guittot, Frédéric Chalmel, Terje Svingen
Publikováno v:
Kugathas, I, Johansson, H K L, Chan Sock Peng, E, Toupin, M, Evrard, B, Darde, T A, Boberg, J, Draskau, M K, Rolland, A D, Mazaud-Guittot, S, Chalmel, F & Svingen, T 2023, ' Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole ', Archives of Toxicology, vol. 97, pp. 849-863 . https://doi.org/10.1007/s00204-023-03442-2
Archives of Toxicology
Archives of Toxicology, 2023, 97 (3), pp.849-863. ⟨10.1007/s00204-023-03442-2⟩
Archives of Toxicology
Archives of Toxicology, 2023, 97 (3), pp.849-863. ⟨10.1007/s00204-023-03442-2⟩
Exposure to endocrine-disrupting chemicals (EDCs) during development may cause reproductive disorders in women. Although female reproductive endpoints are assessed in rodent toxicity studies, a concern is that typical endpoints are not sensitive enou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc064d00a0564016fb619e64450e33a
https://orbit.dtu.dk/en/publications/3d1771d2-2852-4992-9796-cc5d695b3671
https://orbit.dtu.dk/en/publications/3d1771d2-2852-4992-9796-cc5d695b3671