Zobrazeno 1 - 10
of 8 866
pro vyhledávání: '"FoxO1"'
Autor:
Caiyu Cheng, Mingye Deng, Chubin Cheng, Hangtian Wu, Yutian Wang, Mincheng Lu, Zilong Yao, Kaiqun Li, Xianrong Zhang, Bin Yu
Publikováno v:
Journal of Orthopaedic Translation, Vol 49, Iss , Pp 246-263 (2024)
Background: As the population aging progresses, age-related osteoporosis has become one of the most common and severe chronic degenerative diseases. Due to insufficient understanding of its complex pathomechanisms, current clinical treatments often s
Externí odkaz:
https://doaj.org/article/c265a90773b04d15bccbda080f46b2ea
Autor:
Shirin Assar1comma, Seyed Askar Roghani, Ramin Lotfi, Seyedeh Zahra Shahrokhvand, Bahareh Kardideh, Kheirollah Yari, Bijan Soleymani, Fatemeh Khademi
Publikováno v:
Sudan Journal of Medical Sciences, Vol 19, Iss 3, Pp 389-400 (2024)
Abstract Background: The expression of forkhead box O (FOXO) was found to be connected with developing rheumatoid arthritis (RA), an inflammatory autoimmune disorder. The current study is intended to assess the expression and methylation status of th
Externí odkaz:
https://doaj.org/article/52f1a51f50104557a87d284448f6e4f0
Autor:
Xiu Chen, Heda Zhang, Zheng Fang, Dandan Wang, Yuxin Song, Qian Zhang, Junchen Hou, Sujin Yang, Di Xu, Yinjiao Fei, Wei Zhang, Jian Zhang, Jinhai Tang, Lei Li
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background Obesity and the forkhead box O1(FOXO1) affect the survival of breast cancer patients, but the underlying mechanism remains unclear. We aimed to investigate the role of FOXO1 in obesity-associated-breast cancer. Methods We screened
Externí odkaz:
https://doaj.org/article/f70e6eb810034eb6912fbf20caefb44c
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Objectives Serum/glucocorticoid-inducible kinase 1 (SGK1) gene encodes a serine/threonine protein kinase that plays an essential role in cellular stress response and regulation of multiple metabolic processes. However, its role in bovine adi
Externí odkaz:
https://doaj.org/article/63e7807a6eb74072ac4f3da16000bd9d
Publikováno v:
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 32, Iss 4, Pp 7754-7764 (2024)
Introduction: Aging and obesity have common symptoms, including glucose and lipid metabolism changes. Activation of sirtuin 1 and FOXO1 (Forkhead Box Protein O1) can positively affect metabolic disorders associated with aging and obesity. This resear
Externí odkaz:
https://doaj.org/article/9112cc40eba54c62abc24f4b3faec479
Autor:
Erika Tanaka, Michiyo Koyanagi-Aoi, So Nakagawa, Sayumi Shimode, Hideto Yamada, Yoshito Terai, Takashi Aoi
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 729-740 (2024)
Introduction: In human placental development, the trophectoderm (TE) appears in blastocysts on day 5 post-fertilization and develops after implantation into three types of trophoblast lineages: cytotrophoblast (CT), syncytiotrophoblast (ST), and extr
Externí odkaz:
https://doaj.org/article/9e4349023813422f9a669da5664f173b
Autor:
Mélusine Monrose, Hélène Holota, Guillaume Martinez, Christelle Damon‐Soubeyrand, Laura Thirouard, Emmanuelle Martinot, Edwige Battistelli, Angélique deHaze, Stéphanie Bravard, Christelle Tamisier, Françoise Caira, Charles Coutton, Anne‐Laure Barbotin, Angèle Boursier, Laila Lakhal, Claude Beaudoin, David H. Volle
Publikováno v:
Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)
Abstract Male sexual function can be disrupted by exposure to exogenous compounds that cause testicular physiological alterations. The constitutive androstane receptor (Car) is a receptor for both endobiotics and xenobiotics involved in detoxificatio
Externí odkaz:
https://doaj.org/article/5c0cfff5dc2646119bde8165b727621e
Autor:
Jiaqi Xu, Chaoran Shi, Yinghe Ding, Tian Qin, Chengjun Li, Feifei Yuan, Yudong Liu, Yong Xie, Yiming Qin, Yong Cao, Tianding Wu, Chunyue Duan, Hongbin Lu, Jianzhong Hu, Liyuan Jiang
Publikováno v:
Advanced Science, Vol 11, Iss 43, Pp n/a-n/a (2024)
Abstract Reconstruction of the neurovascular unit is essential for the repair of spinal cord injury (SCI). Nonetheless, detailed documentation of specific vascular changes following SCI and targeted interventions for vascular treatment remains limite
Externí odkaz:
https://doaj.org/article/d69f007d5bec4a4d8756ebf89d75674f
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 287, Iss , Pp 117253- (2024)
Cadmium (Cd), a potentially toxic elements, has the potential to cause harm to the kidneys. Studies has demonstrated that autophagosome-lysosome fusion blockade and consequent autophagy inhibition is related to Cd-induced kidney injury. Studies indic
Externí odkaz:
https://doaj.org/article/e1825a25caab4075a8e0fe4512dde0b5
Publikováno v:
Journal of Functional Foods, Vol 122, Iss , Pp 106475- (2024)
Ginsenoside Rd, one of the major components entering into the circulation from ginseng, is beneficial to health; however, its role and mechanism in improving T2DM require further exploration. In the current study, we explored the hypoglycemic effects
Externí odkaz:
https://doaj.org/article/1680836eed064b05af5db0f34f03e92b