Zobrazeno 1 - 10
of 5 066
pro vyhledávání: '"FoxO"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Non-small cell lung cancer (NSCLC), being the most prevalent and lethal malignancy affecting the lungs, poses a significant threat to human health. This research aims at illustrating the precise role and related mechanisms of silent informat
Externí odkaz:
https://doaj.org/article/c4df600be0f94572915aa738642be691
Publikováno v:
FEBS Open Bio, Vol 14, Iss 8, Pp 1230-1246 (2024)
The cellular response to oxidants or xenobiotics comprises two key pathways, resulting in modulation of NRF2 and FOXO transcription factors, respectively. Both mount a cytoprotective response, and their activation relies on crucial protein thiol moie
Externí odkaz:
https://doaj.org/article/00b20c05a08748aeb681c99bebfbb15c
Autor:
Jiaxin Chen, Zhuoshi Wang, Jinghao Fu, Yuesong Cai, Haoyi Cheng, Xinmu Cui, Manqing Sun, Mingyue Liu, Xuewu Zhang
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Liver cancer is a common malignant tumor worldwide, traditional Chinese medicine is one of the treatment measures for liver cancer because of its good anti-tumor effects and fewer toxic side effects. Ginsenoside CK (CK) is an active componen
Externí odkaz:
https://doaj.org/article/c2b4ffd0c2bc4595b7339161d23d5bf5
Autor:
Nivedhitha Velayutham, Jessica C. Garbern, Hannah L. T. Elwell, Zhu Zhuo, Laura Rüland, Farid Elcure Alvarez, Sara Frontini, Yago Rodriguez Carreras, Marie Eichholtz, Elisabeth Ricci‐Blair, Jeanna Y. Shaw, Aldric H. Bouffard, Morgan Sokol, Estela Mancheño Juncosa, Seth Rhoades, Daphne van den Berg, Alexander Kreymerman, Junya Aoyama, Jens Höfflin, Herb Ryan, Shannan Ho Sui, Richard T. Lee
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)
Background Current protocols generate highly pure human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs) in vitro that recapitulate characteristics of mature in vivo cardiomyocytes. Yet, a risk of arrhythmias exists when hiPSC‐C
Externí odkaz:
https://doaj.org/article/0f6ccd0ad57e4a3b9de0de5968e8b89e
Autor:
Chunjiao Yang, Lina Wu, Xin Jin, Aoran Liu, Zhitao Jing, Chuhan Feng, Zhengting Guo, Yuzhe Zhang, Yanju Ma, Fang Li, Zhenpeng Wen, Lirong Yan, Yi Yang, Xu Ji, Ye Zhang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116847- (2024)
Luteolin, a monomeric substance, is a natural product of the Brucea javanica (BJ) plant. Brucea javanica oil emulsion injection (BJOEI) is a proprietary Chinese medicine purified from BJ that is widely used clinically as an anti-tumor treatment. Alth
Externí odkaz:
https://doaj.org/article/33a094f95c0e4090bcb1455393c49df4
Autor:
Cai-Mei Zheng, Yi-Chou Hou, Min-Tser Liao, Kuo-Wang Tsai, Wan-Chung Hu, Chien-Chih Yeh, Kuo-Cheng Lu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116802- (2024)
Oxidative stress plays a key role in chronic kidney disease (CKD) development and progression, inducing kidney cell damage, inflammation, and fibrosis. However, effective therapeutic interventions to slow down CKD advancement are currently lacking. T
Externí odkaz:
https://doaj.org/article/bc92e9d6d71446c9983f2b9ccd40dcd4
Autor:
Won Min Jeong, Seung-Jin Kwag, Jun Young Ha, Seung-Jun Lee, Yeong-In Choe, Dong Yeol Lee, Dong Kyu Jeong, Hwan Hee Bae, Jin-Hee Seo, Young-Sool Hah, Sang Gon Kim
Publikováno v:
Applied Biological Chemistry, Vol 67, Iss 1, Pp 1-11 (2024)
Abstract Muscle atrophy, a debilitating condition characterized by loss of muscle mass and strength, is a major concern in various clinical settings. Acetyl genistin (AG), a bioactive compound, was evaluated for its role in muscle cell differentiatio
Externí odkaz:
https://doaj.org/article/0b70a6f680c04b089184423f0c81fcab
Publikováno v:
Cell Regeneration, Vol 13, Iss 1, Pp 1-23 (2024)
Abstract Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately balanced between maintaining their pluripotency and differentiating as needed. Disruptions in
Externí odkaz:
https://doaj.org/article/eb0277fa628d4d4fbc2f8a2c5437214a
Publikováno v:
eLife, Vol 13 (2024)
Cognitive decline is a significant health concern in our aging society. Here, we used the model organism C. elegans to investigate the impact of the IIS/FOXO pathway on age-related cognitive decline. The daf-2 Insulin/IGF-1 receptor mutant exhibits a
Externí odkaz:
https://doaj.org/article/c036c258dbf64fbfb22dffad196fb5d2