Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Autor: de Las Fuentes, Lisa, Sung, Yun Ju, Noordam, Raymond, Winkler, Thomas, Feitosa, Mary F, Schwander, Karen, Bentley, Amy R, Brown, Michael R, Guo, Xiuqing, Manning, Alisa, Chasman, Daniel I, Aschard, Hugues, Bartz, Traci M, Bielak, Lawrence F, Campbell, Archie, Cheng, Ching-Yu, Dorajoo, Rajkumar, Hartwig, Fernando P, Horimoto, ARVR, Li, Changwei, Li-Gao, Ruifang, Liu, Yongmei, Marten, Jonathan, Musani, Solomon K, Ntalla, Ioanna, Rankinen, Tuomo, Richard, Melissa, Sim, Xueling, Smith, Albert V, Tajuddin, Salman M, Tayo, Bamidele O, Vojinovic, Dina, Warren, Helen R, Xuan, Deng, Alver, Maris, Boissel, Mathilde, Chai, Jin-Fang, Chen, Xu, Christensen, Kaare, Divers, Jasmin, Evangelou, Evangelos, Gao, Chuan, Girotto, Giorgia, Harris, Sarah E, He, Meian, Hsu, Fang-Chi, Kühnel, Brigitte, Laguzzi, Federica, Li, Xiaoyin, Lyytikäinen, Leo-Pekka, Nolte, Ilja M, Poveda, Alaitz, Rauramaa, Rainer, Riaz, Muhammad, Rueedi, Rico, Shu, Xiao-Ou, Snieder, Harold, Sofer, Tamar, Takeuchi, Fumihiko, Verweij, Niek, Ware, Erin B, Weiss, Stefan, Yanek, Lisa R, Amin, Najaf, Arking, Dan E, Arnett, Donna K, Bergmann, Sven, Boerwinkle, Eric, Brody, Jennifer A, Broeckel, Ulrich, Brumat, Marco, Burke, Gregory, Cabrera, Claudia P, Canouil, Mickaël, Chee, Miao Li, Chen, Yii-Der Ida, Cocca, Massimiliano, Connell, John, de Silva, H Janaka, de Vries, Paul S, Eiriksdottir, Gudny, Faul, Jessica D, Fisher, Virginia, Forrester, Terrence, Fox, Ervin F, Friedlander, Yechiel, Gao, He, Gigante, Bruna, Giulianini, Franco, Gu, Chi Charles, Gu, Dongfeng, Harris, Tamara B, He, Jiang, Heikkinen, Sami, Heng, Chew-Kiat, Hunt, Steven, Ikram, M Arfan, Irvin, Marguerite R, Kähönen, Mika, Kavousi, Maryam

Publikováno v: Molecular psychiatry, vol 26, iss 6

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educ

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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

Autor: de las Fuentes L; Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO, 63110, USA. lfuentes@wustl.edu.; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA. lfuentes@wustl.edu., Sung YJ; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA. yunju@wustl.edu., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., Winkler T; Department of Genetic Epidemiology, University of Regensburg, 93051, Regensburg, Germany., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63108, USA., Schwander K; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Manning A; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA, 02115, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Aschard H; Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA.; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, 75724, France., Bartz TM; Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA, 98101, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Campbell A; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Ecy Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Dorajoo R; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, 138672, Singapore., Hartwig FP; Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, 96020-220, Brazil.; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK., Horimoto ARVR; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, 5403000, Brazil., Li C; Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, GA, 30602, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333ZA, Netherlands., Liu Y; Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA., Marten J; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Musani SK; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39213, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Richard M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 70808, USA., Sim X; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.; Icelandic Heart Association, Kopavogur, 201, Iceland., Tajuddin SM; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Tayo BO; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, 60153, USA., Vojinovic D; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Warren HR; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, London, EC1M 6BQ, UK., Xuan D; Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Alver M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.; Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010, Estonia., Boissel M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France., Chai JF; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore., Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden., Christensen K; Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, 5000, Denmark., Divers J; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Evangelou E; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, 45110, Greece., Gao C; Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Girotto G; Medical Genetics, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, 34100, Italy.; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, 34100, Italy., Harris SE; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK., He M; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Hsu FC; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Kühnel B; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany., Laguzzi F; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden., Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.; Department of Mathematics and Statistics, University of Minnesota, Duluth, MN, 55812, USA., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, University of Tampere, Tampere, 33014, Finland., Nolte IM; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, 9700RB, The Netherlands., Poveda A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Skåne, 205 02, Sweden., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Riaz M; College of Medicine, Biological Sciences and Psychology, Health Sciences, The Infant Mortality and Morbidity Studies (TIMMS), Leicester, LE1 7RH, UK., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA., Snieder H; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, 9700RB, The Netherlands., Sofer T; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 1628655, Japan., Verweij N; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700, The Netherlands., Ware EB; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 9713GZ, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, 17475, Greifswald, Germany., Yanek LR; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Arnett DK; Dean's Office, University of Kentucky College of Public Health, Lexington, KY, 40536, USA., Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, 1011, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA., Brody JA; Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA, 98101, USA., Broeckel U; Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Brumat M; Medical Genetics, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, 34100, Italy., Burke G; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA., Cabrera CP; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, London, EC1M 6BQ, UK., Canouil M; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France., Chee ML; Statistics Unit, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., Chen YI; The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Cocca M; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, 34100, Italy., Connell J; Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, DD1 9SY, UK., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., de Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Eiriksdottir G; Icelandic Heart Association, Kopavogur, 201, Iceland., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Fisher V; Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Forrester T; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, JMAAW15, Jamaica., Fox EF; Cardiology, Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Friedlander Y; Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, 91120, Israel., Gao H; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK., Gigante B; Cardiovascular Unit, Bioclinicum, Department of Medicine, Karolinska Hospital, Stockholm, 17164, Sweden.; Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd University Hospital, Stockholm, 18288, Sweden., Giulianini F; Brigham and Women's Hospital, Boston, MA, 02215, USA., Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA., Gu D; Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA., He J; Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA.; Medicine, Tulane University School of Medicine, New Orleans, LA, 70112, USA., Heikkinen S; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, 70211, Finland.; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, 70211, Finland., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, 119228, Singapore., Hunt S; Cardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, UT, 84108, USA.; Weill Cornell Medicine in Qatar, Doha, Qatar., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Irvin MR; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, University of Tampere, Tampere, 33014, Finland., Kavousi M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Khor CC; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, 138672, Singapore.; Department of Biochemistry, National University of Singapore, Singapore, 117596, Singapore., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark.; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Koh WP; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.; Health Services and Systems Research, Duke-NUS Medical School, Singapore, 169857, Singapore., Komulainen P; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland., Kraja AT; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63108, USA., Krieger JE; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, 5403000, Brazil., Langefeld CD; Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Li Y; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA., Liang J; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Liewald DCM; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK., Liu CT; Biostatistics, Boston University School of Public Health, Boston, MA, 02118, USA., Liu J; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, 138672, Singapore.; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore., Lohman KK; Public Health Sciences, Biostatistics and Data Science, Wake Forest University Health Sciences, Winston-Salem, NC, 27157, USA., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia., McKenzie CA; Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, JMAAW15, Jamaica., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, 80333, Munich, Germany., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.; Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010, Estonia., Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 BT, The Netherlands., Milani L; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333ZA, Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2333ZA, Netherlands., Nalls MA; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, 20895, USA.; Data Tecnica International, Glen Echo, MD, 20812, USA., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, LE3 9QP, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK., Norris JM; Department of Epidemiology, University of Colorado Denver, Aurora, CO, 80045, USA., O'Connell J; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Ogunniyi A; Department of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria., Padmanabhan S; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Palmer ND; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden., Perls T; Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, 02118, USA., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 85764, Neuherberg, Germany., Petersmann A; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Polasek O; University of Split School of Medicine, Split, Croatia.; University Hospital Split, Split, Croatia.; Psychiatric Hospital 'Sveti Ivan', Zagreb, Croatia., Porteous DJ; Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK., Raffel LJ; Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA, 92868, USA., Rice TK; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Rudan I; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK., Rueda-Ochoa OL; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Ecy Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Salako BL; Department of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria., Schreiner PJ; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA., Shikany JM; Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 25249, USA., Sidney SS; Division of Research, Kaiser Permanente of Northern California, Oakland, CA, USA., Sims M; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39213, USA., Sitlani CM; Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA, 98101, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Starr JM; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, EH8 9AZ, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Institute of Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians-Universitat Munchen, 80539, Munich, Germany., Swertz MA; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, 9700RB, The Netherlands., Teumer A; DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, 17475, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany., Tham YC; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Ecy Centre, Singapore, 169856, Singapore., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Vaidya D; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., van der Ende MY; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700, The Netherlands., Waldenberger M; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 85764, Neuherberg, Germany., Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63108, USA., Wang YX; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, 100730, Beijing, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 100730, Beijing, China., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Yu B; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Yu C; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Yuan JM; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, , University of Pittsburgh, Pittsburgh, PA, 15232, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Zonderman AB; Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Becker DM; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Bowden DW; Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Deary IJ; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK., Dörr M; DZHK (German Centre for Cardiovascular Health), Partner Site Greifswald, 17475, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, 17475, Greifswald, Germany., Esko T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, MA, 02142, USA., Freedman BI; Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-, Salem, NC, 27157, USA., Froguel P; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, 59000, France.; Department of Genomics of Common Disease, Imperial College London, London, W12 0NN, UK., Gasparini P; Medical Genetics, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, 34100, Italy.; Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, 34100, Italy., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), 85764, Neuherberg, Germany., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, 68167, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, 100730, Beijing, China., Kammerer CM; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, 1628655, Japan., Lakka TA; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, 70211, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, 70211, Finland., Leander K; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, University of Tampere, Tampere, 33014, Finland., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, 17177, Sweden., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, 1011, Switzerland., Penninx BWJH; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, 1081 BT, The Netherlands., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, LE3 9QP, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, 9700, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Ultrecht, The Netherlands., Wagenknecht LE; Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA., Wu T; Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Cooper RS; Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, 60153, USA., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39213, USA., Evans MK; Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Gudnason V; Icelandic Heart Association, Kopavogur, 201, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Horta BL; Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, 96020-220, Brazil., Kelly TN; Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, 70112, USA., Kritchevsky SB; Sticht Center for Health Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA., Levy D; NHLBI Framingham Heart Study, Framingham, MA, 01702, USA.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA., Palmas WR; Division of General Medicine, Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA., Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, SP, 5403000, Brazil., Province MM; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63108, USA., Psaty BM; Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, 98101, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA., Ridker PM; Harvard Medical School, Boston, MA, 02115, USA.; Brigham and Women's Hospital, Boston, MA, 02215, USA., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Tai ES; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.; Health Services and Systems Research, Duke-NUS Medical School, Singapore, 169857, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., van Duijn CM; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Ecy Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Rice K; Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA., Gauderman WJ; Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, CA, 90032, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., North KE; Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, NC, 27514, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, London, EC1M 6BQ, UK., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, London, EC1M 6BQ, UK., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Skåne, 205 02, Sweden.; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Västerbotten, 901 85, Sweden., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, 63110, USA., Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 70808, USA.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2021 Jun; Vol. 26 (6), pp. 2111-2125. Date of Electronic Publication: 2020 May 05.