Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Fox, Darrell E."'
Autor:
Smith Julian Duncan, Stephen Challenger, Alan John Pettman, Fox Darrell E, Pierre Pascal, Lynsey C. Hesmondhalgh, Yann Dessi
Publikováno v:
Organic Process Research & Development. 12:575-583
The development and utilization of a scaleable process for the manufacture of the A2a agonist UK-371,104 (1) is described. Key steps in the synthesis include (i) a palladium-catalyzed cyanation reaction to prepare the nitrile 10, (ii) a telescoped co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00f75768328e2dd8d4fe7176397ea66a
https://doi.org/10.1021/op700248t
https://doi.org/10.1021/op700248t
Publikováno v:
Organic Process Research & Development. 8:587-592
Previously our group reported synthetic efforts used to synthesize kilogram quantities of the β-3 receptor agonist (R)-(4-(2-(2-(6-aminopyridin-3-yl)-2-hydroxyethylamino)ethoxy)phenyl)acetic acid, 1. Additional research was conducted to explore an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1c458bd4bd1bf81a4d94daee116fa1
https://doi.org/10.1021/op0499775
https://doi.org/10.1021/op0499775
Autor:
Devries Keith Michael, Frank J. Urban, Michael W. Snyder, Brian C. Vanderplas, Raggon Jeffrey W, Fox Darrell E
Publikováno v:
Organic Process Research & Development. 8:583-586
A scaleable synthesis of the β-3 adrenergic receptor agonist, (4-{2-[2-(6-aminopyridin-3-yl)-(2R)-hydroxy-ethylamino]ethoxy}phenyl)acetic acid is presented. The key coupling step utilizes a silyl-p...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f9a3a675b0283cd924875d53aea249
https://doi.org/10.1021/op049969o
https://doi.org/10.1021/op049969o
Publikováno v:
Tetrahedron Letters. 41:8207-8210
A method to form glycosyl linkages between nitrogen-containing heterocycles and appropriately protected furanoses is described. The method is highly beta-selective, operationally simple, and utilizes readily available reagents making the process amen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6aaf3096b1ae38461d8ea1b2f359a7e
https://doi.org/10.1016/s0040-4039(00)01429-5
https://doi.org/10.1016/s0040-4039(00)01429-5
Publikováno v:
Organic Process Research & Development. 3:126-130
A new, one-step commercial process for the preparation of 3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride, a key intermediate for the syntheses of some new, “atypical antipsychotic” drugs, was ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41439ad45d639df506bc3724e9004c85
https://doi.org/10.1021/op980210k
https://doi.org/10.1021/op980210k
Autor:
Fox Darrell E, Braish Tamim F
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df8ac12dfdf9ebc77c41d4bfb98b5f1b
https://doi.org/10.1002/chin.199208162
https://doi.org/10.1002/chin.199208162
Autor:
Braish Tamim F, Fox Darrell E
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5215614be92b50607beeee06955be68
https://doi.org/10.1002/chin.199342164
https://doi.org/10.1002/chin.199342164
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::984d2b82367717d8ca9b9a3b38e479e4
https://doi.org/10.1002/chin.199929155
https://doi.org/10.1002/chin.199929155
Autor:
Braish Tamim F, Fox Darrell E
Publikováno v:
Synthetic Communications. 22:3067-3074
The synthesis of 2-bromo-4, 5-difluorobenzoic acid was achieved from difluorophthalic anhydride by either using a Losen rearrangement or the Barton bromodecarboxylation reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bae81e56375f6df748d0d93c29eb2c5
https://doi.org/10.1080/00397919209409255
https://doi.org/10.1080/00397919209409255
Publikováno v:
The Journal of Organic Chemistry. 57:761-764
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1768910eaaf85c557b6c334b85a5c64d
https://doi.org/10.1021/jo00028a070
https://doi.org/10.1021/jo00028a070