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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients

Autor: Vissers, M.F.J.M., Heuberger, J.A.A.C., Groeneveld, G.J., Nijhuis, J.O., Deyn, P.P. de, Hadi, S., Harris, J., Tsai, R.M., Cruz-Herranz, A., Huang, F., Tong, V., Erickson, R., Zhu, Y.D., Scearce-Levie, K., Hsiao-Nakamoto, J., Tang, X.Y., Chang, M., Fox, B.M., Pomponio, R.J., Alonso-Alonso, M., Zilberstein, M., Atassi, N., Troyer, M.D., Ho, C.

Publikováno v: Clinical and translational science, 15(8), 2010-2023. Wiley
Clinical and Translational Science, 15(8), 2010-2023. WILEY
Clinical and translational science

RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1 activity is observed in human diseases, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). RIPK1 inhibition has been shown to protect ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::af01500ec9f2208e7f2c9d74b053cf6c
https://research.rug.nl/en/publications/68746f94-9889-48a0-8f8d-428a9c348bbf

PET/CT in anal cancer — is it worth doing?

Autor: Wells, I.T., Fox, B.M.

Publikováno v: In Clinical Radiology June 2012 67(6):535-540

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The position of the popliteal artery in the arthritic knee

Autor: Farrington, W.J., Charnley, G.J., Harries, S.R., Fox, B.M., Sharp, R., Hughes, P.M.

Publikováno v: In The Journal of Arthroplasty 1999 14(7):800-802