mEAK-7 Forms an Alternative mTOR Complex with DNA-PKcs in Human Cancer

Autor: Nguyen, Joe Truong, Haidar, Fatima Sarah, Fox, Alexandra Lucienne, Ray, Connor, Mendonça, Daniela Baccelli, Kim, Jin Koo, Krebsbach, Paul H.

Publikováno v: In iScience 26 July 2019 17:190-207

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Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.

Autor: Nguyen JT; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48105, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA., Ray C; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48105, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA., Fox AL; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48105, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA., Mendonça DB; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48105, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA., Kim JK; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48105, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA.; Section of Periodontics, University of California, Los Angeles, Los Angeles, CA 90095, USA., Krebsbach PH; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48105, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48105, USA.; Section of Periodontics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Publikováno v: Science advances [Sci Adv] 2018 May 09; Vol. 4 (5), pp. eaao5838. Date of Electronic Publication: 2018 May 09 (Print Publication: 2018).