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Energy metabolism in the failing right ventricle: Limitations of oxygen delivery and the creatine kinase system

Autor: Fowler, ED, Hauton, D, Boyle, J, Egginton, S, Steele, DS, White, E

Publikováno v: Fowler, E D, Hauton, D, Boyle, J, Egginton, S, Steele, D S & White, E 2019, ' Energy metabolism in the failing right ventricle : Limitations of oxygen delivery and the creatine kinase system ', International Journal of Molecular Sciences, vol. 20, no. 8, 1805 . https://doi.org/10.3390/ijms20081805
International Journal of Molecular Sciences
Volume 20
Issue 8
International Journal of Molecular Sciences, Vol 20, Iss 8, p 1805 (2019)

Pulmonary arterial hypertension (PAH) results in hypertrophic remodeling of the right ventricle (RV) to overcome increased pulmonary pressure. This increases the O2 consumption of the myocardium, and without a concomitant increase in energy generatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a8cb2ca3441f447a3ba79db118fdffa3

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Beta1-adrenoceptor antagonist, metoprolol attenuates cardiac myocyte Ca²⁺ handling dysfunction in rats with pulmonary artery hypertension

Autor: Fowler, ED, Drinkhill, MJ, Norman, R, Pervolaraki, E, Stones, R, Steer, E, Benoist, D, Steele, DS, Calaghan, SC, White, E

Right heart failure is the major cause of death in Pulmonary Artery Hypertension (PAH) patients but is not a current, specific therapeutic target. Pre-clinical studies have shown that adrenoceptor blockade can improve cardiac function but the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::44ebfccded569e2eb81bff99bcc96fe8
https://eprints.whiterose.ac.uk/131352/3/1-s2.0-S0022282818301767-main.pdf

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Diastolic dysfunction in pulmonary artery hypertension:Creatine kinase and the potential therapeutic benefit of beta-blockers

Autor: Fowler, ED, Drinkhill, MJ, Stones, R, White, E

Publikováno v: Fowler, E D, Drinkhill, M J, Stones, R & White, E 2018, ' Diastolic dysfunction in pulmonary artery hypertension : Creatine kinase and the potential therapeutic benefit of beta-blockers ', Clinical and Experimental Pharmacology and Physiology . https://doi.org/10.1111/1440-1681.12898
Clinical and Experimental Pharmacology & Physiology

Summary Passive properties of the myocardium influence diastolic filling and cardiac output. In heart failure, changes in contributors to the passive properties of the ventricle, such as titin and collagen, and loss of the metabolic enzyme creatine k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c2484ce34309785c303716f61cf16803
https://research-information.bris.ac.uk/en/publications/0cd884f8-958d-418d-87ca-68e6d7281bc5

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Synergisitic role of ADP and Ca2+ in diastolic myocardial stiffness

Autor: Sequeira, V, Najafi, A, McConnell, M, Fowler, ED, Bollen, IAE, Wust, RCI, dos Remedios, C, Helmes, M, White, E, Stienen, GJM, Tardiff, J, Kuster, DWD, Van der Velden, J

Heart failure (HF) with diastolic dysfunction has been attributed to increased myocardial stiffness that limits proper filling of the ventricle. Altered cross-bridge interaction may significantly contribute to high diastolic stiffness, but this has n

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Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension

Autor: Fowler, ED, Benoist, D, Drinkhill, MJ, Stones, R, Helmes, M, Wüst, RCI, Stienen, GJM, Steele, DS, White, E

Publikováno v: Fowler, E D, Benoist, D, Drinkhill, M J, Stones, R, Helmes, M H B, Wüst, R C I, Stienen, G J M, Steele, D S & White, E 2015, ' Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension ', Journal of Molecular and Cellular Cardiology, vol. 86, pp. 1-8 . https://doi.org/10.1016/j.yjmcc.2015.06.016
Journal of molecular and cellular cardiology, 86, 1-8. Academic Press Inc.
Journal of Molecular and Cellular Cardiology, 86, 1-8. Academic Press Inc.
Journal of Molecular and Cellular Cardiology

Our objective was to investigate the role of creatine kinase in the contractile dysfunction of right ventricular failure caused by pulmonary artery hypertension. Pulmonary artery hypertension and right ventricular failure were induced in rats by mono

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