New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine

Autor: Relling, MV, Krauss, RM, Roden, DM, Klein, TE, Fowler, DM, Terada, N, Lin, L, Riel-Mehan, M, Do, TP, Kubo, M, Yee, SW, Johnson, GT, Giacomini, KM

Publikováno v: Clinical pharmacology and therapeutics, vol 102, iss 6

The goal of pharmacogenomics research is to discover genetic polymorphisms that underlie variation in drug response. Increasingly, pharmacogenomics research involves large numbers of patients and the application of new technologies and methodologies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::efde5210c44066781cc205ccaa4446e2
https://escholarship.org/uc/item/78p807fd

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Deep mutational scanning of CYP2C19 in human cells reveals a substrate specificity-abundance tradeoff.

Autor: Boyle GE; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Sitko KA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Galloway JG; Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Haddox HK; Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Bianchi AH; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Dixon A; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Wheelock MK; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Vandi AJ; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Wang ZR; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Thomson RES; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4067, Australia., Garge RK; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA 98195, USA., Rettie AE; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA., Rubin AF; Bioinformatics Division, Walter and Eliza Hall Institute, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Geck RC; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Gillam EMJ; School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4067, Australia., DeWitt WS; Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA 94720, USA., Matsen FA 4th; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Seattle, WA 98109, USA.; Department of Statistics, University of Washington, Seattle, WA 98195, USA., Fowler DM; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.

Publikováno v: Genetics [Genetics] 2024 Nov 06; Vol. 228 (3).

Retinoic acid induces human gastruloids with posterior embryo-like structures.

Autor: Hamazaki N; Department of Genome Sciences, University of Washington, Seattle, WA, USA. hamazaki@uw.edu.; Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA. hamazaki@uw.edu.; Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA, USA. hamazaki@uw.edu.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA. hamazaki@uw.edu.; Seattle Hub for Synthetic Biology, Seattle, WA, USA. hamazaki@uw.edu., Yang W; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Kubo CA; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Qiu C; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Martin BK; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Garge RK; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Regalado SG; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA.; Medical Scientist Training Program, University of Washington, Seattle, WA, USA., Nichols EK; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Pendyala S; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Bradley N; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Fowler DM; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Lee C; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Daza RM; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Seattle Hub for Synthetic Biology, Seattle, WA, USA., Srivatsan S; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.; Fred Hutchinson Cancer Center, Seattle, WA, USA., Shendure J; Department of Genome Sciences, University of Washington, Seattle, WA, USA. shendure@uw.edu.; Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA, USA. shendure@uw.edu.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA. shendure@uw.edu.; Seattle Hub for Synthetic Biology, Seattle, WA, USA. shendure@uw.edu.; Howard Hughes Medical Institute, Seattle, WA, USA. shendure@uw.edu.; Allen Discovery Center for Cell Lineage Tracing, Seattle, WA, USA. shendure@uw.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2024 Oct; Vol. 26 (10), pp. 1790-1803. Date of Electronic Publication: 2024 Aug 20.