Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration

Autor: Joyce Mordenti, Valverde Cr, Fei Dt, Licko, Lea T. Berleau, Anne M. Ryan, R A Cuthbertson, Napoleone Ferrara, Fourre Km, Y G Meng, Allen Pc, K Thomsen

Publikováno v: Toxicologic pathology. 27(5)

Access of recombinant proteins to the retina following intravitreal administration is poorly understood. A study was conducted in male Rhesus monkeys (15 to 28 mo of age; 2.8-3.3 kg) in order to compare the intraocular tissue distribution, pharmacoki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5fc38cba3520a69393f5503ea068ab
https://pubmed.ncbi.nlm.nih.gov/10528633

Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration.

Autor: Mordenti J; Department of Experimental Therapeutics, Genentech, Inc., Souty San Francisco, California 94080, USA., Cuthbertson RA, Ferrara N, Thomsen K, Berleau L, Licko V, Allen PC, Valverde CR, Meng YG, Fei DT, Fourre KM, Ryan AM

Publikováno v: Toxicologic pathology [Toxicol Pathol] 1999 Sep-Oct; Vol. 27 (5), pp. 536-44.