Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Fouad, Kandeel"'
Autor:
Diana Esparza, Carinna Lima, Sarah Abuelreich, Ima Ghaeli, Jinhee Hwang, Eunjin Oh, Ayelet Lenz, Angel Gu, Nan Jiang, Fouad Kandeel, Debbie C. Thurmond, Tijana Jovanovic-Talisman
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionDouble C2-like domain beta (DOC2B) is a vesicle priming protein critical for glucose-stimulated insulin secretion in β-cells. Individuals with type 1 diabetes (T1D) have lower levels of DOC2B in their residual functional β-cell mass and
Externí odkaz:
https://doaj.org/article/49be9d7536124d169961b687cb510217
Autor:
Hiroyuki Kato, Mayra Salgado, Daniel Mendez, Nelson Gonzalez, Jeffrey Rawson, Doreen Ligot, Bennie Balandran, Chris Orr, Janine C. Quijano, Keiko Omori, Meirigeng Qi, Ismail H. Al-Abdullah, Yoko Mullen, Hsun Teresa Ku, Fouad Kandeel, Hirotake Komatsu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Evaluating the quality of isolated human islets before transplantation is crucial for predicting the success in treating Type 1 diabetes. The current gold standard involves time-intensive in vivo transplantation into diabetic immunodeficient
Externí odkaz:
https://doaj.org/article/e4c92950caa44443bef83e5c39527a56
Autor:
Hiroyuki Kato, Huajian Chen, Kuang-Ming Shang, Kenji Izumi, Naoya Koba, Takanori Tsuchiya, Naoki Kawazoe, Janine Quijano, Keiko Omori, Chris Orr, Meirigeng Qi, Hsun Teresa Ku, Fouad Kandeel, Yu-Chong Tai, Guoping Chen, Hirotake Komatsu
Publikováno v:
Cell Transplantation, Vol 33 (2024)
Pancreatic islet transplantation is one of the clinical options for certain types of diabetes. However, difficulty in maintaining islets prior to transplantation limits the clinical expansion of islet transplantations. Our study introduces a dynamic
Externí odkaz:
https://doaj.org/article/5bd294cb3a824e56a8d2d219d5f74665
Autor:
Heather N. Zook, Janine C. Quijano, Jose A. Ortiz, Cecile Donohue, Kassandra Lopez, Wendong Li, Neslihan Erdem, Kevin Jou, Christiana J. Crook, Isaac Garcia, Jr., Fouad Kandeel, Enrique Montero, Hsun Teresa Ku
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109237- (2024)
Summary: Ductal progenitor-like cells are a sub-population of ductal cells in the adult human pancreas that have the potential to contribute to regenerative medicine. However, the microenvironmental cues that regulate their activation are poorly unde
Externí odkaz:
https://doaj.org/article/2fdc19767cbe4e75960c9bb4dbf83843
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303863 (2024)
Type 1 diabetes (T1D)-associated hyperglycemia develops, in part, from loss of insulin-secreting beta cells. The degree of glycemic dysregulation and the age at onset of disease can serve as indicators of the aggressiveness of the disease. Tracking b
Externí odkaz:
https://doaj.org/article/0659856f51fa41f1bf00e8c35ddc7d61
Autor:
Jacob Cobb, Jeffrey Rawson, Nelson Gonzalez, Mahmoud Singer, Fouad Kandeel, Mohamed I. Husseiny
Publikováno v:
Vaccines, Vol 12, Iss 3, p 276 (2024)
A combination therapy of preproinsulin (PPI) and immunomodulators (TGFβ+IL10) orally delivered via genetically modified Salmonella and anti-CD3 promoted glucose balance in in NOD mice with recent onset diabetes. The Salmonella bacteria were modified
Externí odkaz:
https://doaj.org/article/3b15bc7880c64a608ad946ed362ae014
Autor:
Nelson Gonzalez, Hiroyuki Kato, Wilma Tixi, Jose Ortiz, Chris Orr, Hung-Ping Shih, Hsun Teresa Ku, Jiing-Kuan Yee, Fouad Kandeel, Yoko Mullen, Eiji Kobayashi, Hirotake Komatsu
Publikováno v:
Cell Transplantation, Vol 32 (2023)
“Firefly rats” ubiquitously express the luciferase reporter gene under the control of constitutively active ROSA26 promoter in inbred Lewis rats. Due to the minimal immunogenicity of luciferase, wide applications of Firefly rats have been reporte
Externí odkaz:
https://doaj.org/article/d9939e4fbe0148df8740c480b1a26889
Autor:
Jiangling Peng, Wei Tang, Jeffrey Rawson, Lynn Miao, Nelson Gonzalez, Runkai Yin, Jiaqi Chen, Melinda Ji, Zhixuan Li, Anna Gao, Andy Z. Wu, John E. Shively, Fouad Kandeel, Junfeng Li
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1480 (2023)
Recently, a G-protein coupled receptor 44 (GPR44) was discovered to play a significant role in the process of inflammation-related diseases, including cancer and diabetes. However, the precise role of GPR44 has yet to be fully elucidated. Currently,
Externí odkaz:
https://doaj.org/article/9651c4ece46445dc974b3f96b53e9d6d
Autor:
Jacob Cobb, Sameh S M Soliman, Mauricio Retuerto, Janine C Quijano, Chris Orr, Mahmoud Ghannoum, Fouad Kandeel, Mohamed I Husseiny
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285905 (2023)
We developed an oral Salmonella-based vaccine that prevents and reverses diabetes in non-obese diabetic (NOD) mice. Related to this, the gastrointestinal tract harbors a complex dynamic population of microorganisms, the gut microbiome, that influence
Externí odkaz:
https://doaj.org/article/0979359f82844f5994d5d5b6c71241c0
Autor:
Hiroyuki Kato, Tatsuaki Miwa, Janine Quijano, Leonard Medrano, Jose Ortiz, Akiko Desantis, Keiko Omori, Aya Wada, Kentaro Tatsukoshi, Fouad Kandeel, Yoko Mullen, Hsun Teresa Ku, Hirotake Komatsu
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundTransplantation of the human pancreatic islets is a promising approach for specific types of diabetes to improve glycemic control. Although effective, there are several issues that limit the clinical expansion of this treatment, including d
Externí odkaz:
https://doaj.org/article/464c9420acd848cba8fbb35c40f514de