Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Fotuhi Siahpirani A"'
Publikováno v:
Global Pediatric Health, Vol 11 (2024)
Objective . Children’s vulnerability to drug-related side effects has been highlighted in several studies. However, there is no consensus on the risk factors associated with these side effects. This study aimed to investigate risk factors associate
Externí odkaz:
https://doaj.org/article/2a5ca50b429b49ca9347522fd5d4385d
Autor:
Shilu Zhang, Saptarshi Pyne, Stefan Pietrzak, Spencer Halberg, Sunnie Grace McCalla, Alireza Fotuhi Siahpirani, Rupa Sridharan, Sushmita Roy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Cell type-specific gene expression patterns are outputs of transcriptional gene regulatory networks (GRNs) that connect transcription factors and signaling proteins to target genes. Single-cell technologies such as single cell RNA-sequencing
Externí odkaz:
https://doaj.org/article/6364662bddf240fca2682cce7b73a37f
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 795 (2024)
Background: Drug safety relies on advanced methods for timely and accurate prediction of side effects. To tackle this requirement, this scoping review examines machine-learning approaches for predicting drug-related side effects with a particular foc
Externí odkaz:
https://doaj.org/article/46ffb33ac0c74ee8846a17a3dfee23d1
Autor:
Sunnie Grace McCalla, Alireza Fotuhi Siahpirani, Jiaxin Li, Saptarshi Pyne, Matthew Stone, Viswesh Periyasamy, Junha Shin, Sushmita Roy
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 3 (2023)
AbstractSingle-cell RNA-sequencing (scRNA-seq) offers unparalleled insight into the transcriptional programs of different cellular states by measuring the transcriptome of thousands of individual cells. An emerging problem in the analysis of scRNA-se
Externí odkaz:
https://doaj.org/article/e83a7d7ec76e4aafba58b5e60bc49e0b
Publikováno v:
Pediatric Drugs; Sep2024, Vol. 26 Issue 5, p519-553, 35p
Publikováno v:
Global Pediatric Health; 8/27/2024, p1-9, 9p
Publikováno v:
Pharmaceuticals (14248247); Jun2024, Vol. 17 Issue 6, p795, 22p
Autor:
Kunling Huang, Yuchang Wu, Junha Shin, Ye Zheng, Alireza Fotuhi Siahpirani, Yupei Lin, Zheng Ni, Jiawen Chen, Jing You, Sunduz Keles, Daifeng Wang, Sushmita Roy, Qiongshi Lu
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009309 (2021)
Recent advances in consortium-scale genome-wide association studies (GWAS) have highlighted the involvement of common genetic variants in autism spectrum disorder (ASD), but our understanding of their etiologic roles, especially the interplay with ra
Externí odkaz:
https://doaj.org/article/6e86fb79b0f74239ba4235da585ab660
Autor:
Khoa A. Tran, Stefan J. Pietrzak, Nur Zafirah Zaidan, Alireza Fotuhi Siahpirani, Sunnie Grace McCalla, Amber S. Zhou, Gopal Iyer, Sushmita Roy, Rupa Sridharan
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1726-1741.e5 (2019)
Summary: Elucidating the mechanism of reprogramming is confounded by heterogeneity due to the low efficiency and differential kinetics of obtaining induced pluripotent stem cells (iPSCs) from somatic cells. Therefore, we increased the efficiency with
Externí odkaz:
https://doaj.org/article/8e6a7b35caec4373ae0421253ff37534
Autor:
Alireza Fotuhi Siahpirani, Sara Knaack, Deborah Chasman, Morten Seirup, Rupa Sridharan, Ron Stewart, James Thomson, Sushmita Roy
Publikováno v:
Genome Research. 32:1367-1384
Changes in transcriptional regulatory networks can significantly alter cell fate. To gain insight into transcriptional dynamics, several studies have profiled bulk multi-omic data sets with parallel transcriptomic and epigenomic measurements at diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599bf7044f7a598fe1cb9a2bc07797e4
https://doi.org/10.1101/gr.276542.121
https://doi.org/10.1101/gr.276542.121