Výsledky vyhledávání - "Fossey Stacey L"

Akademický článek

Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines

Autor: Kisseberth William C, Bear Misty D, Fossey Stacey L, Pennell Michael, London Cheryl A

Publikováno v: BMC Cancer, Vol 11, Iss 1, p 125 (2011)

Abstract Background We have previously demonstrated that both canine and human OSA cell lines, as well as 8 fresh canine OSA tumor samples, exhibit constitutive phosphorylation of STAT3, and that this correlates with enhanced expression of matrix met

Externí odkaz: https://doaj.org/article/b982ad3e39584a31a6125e188982993e

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Akademický článek

The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

Autor: Li Pui-Kai, Schwartz Eric B, Li Chenglong, Lin Jiayuh, Bear Misty D, Fossey Stacey L, Fuchs James R, Fenger Joelle, Kisseberth William C, London Cheryl A

Publikováno v: BMC Cancer, Vol 11, Iss 1, p 112 (2011)

Abstract Background Curcumin is a naturally occurring phenolic compound shown to have a wide variety of antitumor activities; however, it does not attain sufficient blood levels to do so when ingested. Using structure-based design, a novel compound,

Externí odkaz: https://doaj.org/article/91e36158d2fc401db3a0ed3b64c00abf

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Akademický článek

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

Autor: Young Gregory S, Fossey Stacey L, Hoyt Dale G, Lin Jiayuh, Abdelhamid Dalia, Schwartz Eric B, Benson Don M, Bakan Courtney, Yui Jennifer, Li Chenglong, Fuchs James R, Bill Matthew A, Carson William E, Li Pui-Kai, Lesinski Gregory B

Publikováno v: Molecular Cancer, Vol 9, Iss 1, p 165 (2010)

Abstract Background We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway t

Externí odkaz: https://doaj.org/article/f3aff333fbda4d3d8d697c842c935fd4

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Akademický článek

Characterization of STAT3 activation and expression in canine and human osteosarcoma

Autor: Li Pui-Kai, Lin Jiayuh, Bear Misty D, McCleese Jennifer K, Liao Albert T, Fossey Stacey L, Kisseberth William C, London Cheryl A

Publikováno v: BMC Cancer, Vol 9, Iss 1, p 81 (2009)

Abstract Background Dysregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a key participant in tumor cell survival, proliferation, and metastasis and is often correlated with a more malignant tumor phenoty

Externí odkaz: https://doaj.org/article/c29123df5994445f8da455af7a76b36e

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