Disruption of the neurexin 1 gene is associated with schizophrenia

Autor: Toulopoulou, T, Wiersma, D, Murray, R, Ruggeri, M, Tosato, S, Bonetto, C, Steinberg, S, Sigurdsson, E, Sigmundsson, T, Petursson, H, Gylfason, A, Olason, PI, Hardarsson, G, Jonsdottir, GA, Cahn, W, de Haan, L, Krabbendam, L, MyinGermeys, I, Werge, T, Kiemeney, LA, Franke, B, Pietiläinen, OPH, Picchioni, M, Vassos, E, Ettinger, U, Rietschel, M, Gustafsson, O, BuizerVoskamp, JE, Fossdal, R, Giegling, I, Sabatti, C, Ophoff, RA, Möller, HJ, Hartmann, AM, Hoffmann, P, Crombie, C, Rujescu, D, Veltman, J, Fraser, G, St Clair, D, Peltonen, L, Stefansson, K, Barnes, MR, Ingason, A, Stefansson, H, Nöthen, MM, Walker, N, Lonnqvist, J, Suvisaari, J, TuulioHenriksson, A, Djurovic, S, Collier, DA, Kahn, RS, Melle, I, Andreassen, OA, Hansen, T, Linszen, D, von Os, J, Bramon, E, Cichon, S, Bruggeman, R

Publikováno v: Human molecular genetics, 18(5), 988-996. Oxford University Press
Human Molecular Genetics, 18, 5, pp. 988-96
Human Molecular Genetics, 18, 988-96
Human Molecular Genetics, 18(5), 988-996. Oxford University Press
Rujescu, D & Krabbendam, L 2009, ' Disruption of the neurexin 1 gene is associated with schizophrenia ', Human Molecular Genetics, vol. 18, no. 5, pp. 988-996 . https://doi.org/10.1093/hmg/ddn351
Human Molecular Genetics; Vol
Human Molecular Genetics

Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined NRXN1, and the closely related NRXN2 and NRXN3 genes, for copy number variants (CNVs) in 2977

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e7f8bb4091edfb1f666d14a1be47e2
https://pure.amc.nl/en/publications/disruption-of-the-neurexin-1-gene-is-associated-with-schizophrenia(2abe7aac-e6ff-4386-b71c-c9bbe97a21a5).html

Large recurrent microdeletions associated with schizophrenia [Letter to Nature]

Autor: Stefansson, H., Rujescu, D., Cichon, S., Pietilainen, O., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., Buizer-Voskamp, J., Hansen, T., Jakobsen, K., Muglia, P., Francks, C., Matthews, P., Gylfason, A., Halldorsson, B., Gudbjartsson, D., Thorgeirsson, T., Sigurdsson, A., Jonasdottir, A., Bjornsson, A., Mattiasdottir, S., Blondal, T., Haraldsson, M., Magnusdottir, B., Giegling, I., Möller, H., Hartmann, A., Shianna, K., Ge, D., Need, A., Crombie, C., Fraser, G., Walker, N., Lonnqvist, J., Suvisaari, J., Tuulio-Henriksson, A., Paunio, T., Toulopoulou, T., Bramon, E., Forti, M., Murray, R., Ruggeri, M., Vassos, E., Tosato, S., Walshe, M., Li, T., Vasilescu, C., Muhleisen, T., Wang, A., Ullum, H., Djurovic, S., Melle, I., Olesen, J., Kiemeney, L., Franke, B., Sabatti, C., Freimer, N., Gulcher, J., Thorsteinsdottir, U., Kong, A., Andreassen, O., Ophoff, R., Georgi, A., Rietschel, M., Werge, T., Petursson, H., Goldstein, D., Nothen, M., Peltonen, L., Collier, D., St. Clair, D., Stefansson, K.

Publikováno v: Nature

Reduced fecundity, associated with severe mental disorders, places negative selection pressure on risk alleles and may explain, in part, why common variants have not been found that confer risk of disorders such as autism, schizophrenia and mental re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1874::cc62db8b9826b0b5a2e92315196dc1a5
https://hdl.handle.net/11858/00-001M-0000-0012-C93F-611858/00-001M-0000-0012-C93E-8

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