Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington's Disease Cells.

Autor: Bryan MR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology and Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA., Nordham KD; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology and Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA., Rose DIR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology and Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA., O'Brien MT; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology and Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA., Joshi P; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology and Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA., Foshage AM; Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA., Gonçalves FM; Albert Einstein College of Medicine, Bronx, NY, USA., Nitin R; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology and Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA., Uhouse MA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Neurology and Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA., Aschner M; Albert Einstein College of Medicine, Bronx, NY, USA., Bowman AB; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. bowma117@purdue.edu.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN, USA. bowma117@purdue.edu.; Department of Neurology and Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA. bowma117@purdue.edu.; Vanderbilt Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA. bowma117@purdue.edu.; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA. bowma117@purdue.edu.; School of Health Sciences, Purdue University, West Lafayette, IN, USA. bowma117@purdue.edu.

Publikováno v: Molecular neurobiology [Mol Neurobiol] 2020 Mar; Vol. 57 (3), pp. 1570-1593. Date of Electronic Publication: 2019 Dec 04.

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.

Autor: Aho ER; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Wang J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Gogliotti RD; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Howard GC; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Phan J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Acharya P; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Macdonald JD; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Cheng K; National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Lorey SL; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Lu B; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Wenzel S; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Foshage AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Alvarado J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Wang F; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Shaw JG; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Zhao B; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Weissmiller AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Thomas LR; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Vakoc CR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Hall MD; National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA., Hiebert SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Liu Q; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Stauffer SR; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA., Fesik SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA., Tansey WP; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: william.p.tansey@vanderbilt.edu.

Publikováno v: Cell reports [Cell Rep] 2019 Mar 12; Vol. 26 (11), pp. 2916-2928.e13.

Interaction of MYC with host cell factor-1 is mediated by the evolutionarily conserved Myc box IV motif.

Autor: Thomas LR; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Foshage AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Weissmiller AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Popay TM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Vanderbilt International Scholar Program, Vanderbilt University, Nashville, TN, USA., Grieb BC; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA., Qualls SJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Ng V; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Carboneau B; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA., Lorey S; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Eischen CM; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA., Tansey WP; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Publikováno v: Oncogene [Oncogene] 2016 Jul 07; Vol. 35 (27), pp. 3613-8. Date of Electronic Publication: 2015 Nov 02.

Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

Autor: Thomas LR; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Wang Q; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Grieb BC; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Phan J; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Foshage AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Sun Q; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Olejniczak ET; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Clark T; VANTAGE, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Dey S; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Lorey S; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Alicie B; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Howard GC; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Cawthon B; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Ess KC; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Eischen CM; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Zhao Z; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Fesik SW; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Tansey WP; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address: william.p.tansey@vanderbilt.edu.

Publikováno v: Molecular cell [Mol Cell] 2015 May 07; Vol. 58 (3), pp. 440-52. Date of Electronic Publication: 2015 Mar 26.

MYC in liver cancer: mechanisms and targeted therapy opportunities.

Autor: Liu F; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, 430030, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China., Liao Z; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, 430030, China.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China., Zhang Z; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. zhanguo_tjh@hust.edu.cn.; Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, 430030, China. zhanguo_tjh@hust.edu.cn.; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, China. zhanguo_tjh@hust.edu.cn.

Publikováno v: Oncogene [Oncogene] 2023 Nov; Vol. 42 (45), pp. 3303-3318. Date of Electronic Publication: 2023 Oct 13.