Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor

Autor: Svenja M. Sake, Xiaoyu Zhang, Manoj Kumar Rajak, Melanie Urbanek-Quaing, Arnaud Carpentier, Antonia P. Gunesch, Christina Grethe, Alina Matthaei, Jessica Rückert, Marie Galloux, Thibaut Larcher, Ronan Le Goffic, Fortune Hontonnou, Arnab K. Chatterjee, Kristen Johnson, Kaycie Morwood, Katharina Rox, Walid A. M. Elgaher, Jiabin Huang, Martin Wetzke, Gesine Hansen, Nicole Fischer, Jean-Francois Eléouët, Marie-Anne Rameix-Welti, Anna K. H. Hirsch, Elisabeth Herold, Martin Empting, Chris Lauber, Thomas F. Schulz, Thomas Krey, Sibylle Haid, Thomas Pietschmann

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory tract infection in infants, older adults and the immunocompromised. Effective directly acting antivirals are not yet available for clinical use. To address this,

Externí odkaz: https://doaj.org/article/66d08a2bbc3740f4a9e811166d229bd4

Macromolecular Viral Entry Inhibitors as Broad‐Spectrum First‐Line Antivirals with Activity against SARS‐CoV‐2

Autor: Rüdiger Groß, Lívia Mesquita Dias Loiola, Leila Issmail, Nadja Uhlig, Valentina Eberlein, Carina Conzelmann, Lia‐Raluca Olari, Lena Rauch, Jan Lawrenz, Tatjana Weil, Janis A. Müller, Mateus Borba Cardoso, Andrea Gilg, Olivia Larsson, Urban Höglund, Sandra Axberg Pålsson, Anna Selch Tvilum, Kaja Borup Løvschall, Maria M. Kristensen, Anna‐Lena Spetz, Fortune Hontonnou, Marie Galloux, Thomas Grunwald, Alexander N. Zelikin, Jan Münch

Publikováno v: Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)

Abstract Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS‐CoV‐2. Macromolecular inhi

Externí odkaz: https://doaj.org/article/efb36e92da2449a5bac3fba657c93ca6

Investigation of the Fuzzy Complex between RSV Nucleoprotein and Phosphoprotein to Optimize an Inhibition Assay by Fluorescence Polarization

Autor: Silva Khodjoyan, Deborha Morissette, Fortune Hontonnou, Luis Checa Ruano, Charles-Adrien Richard, Olivier Sperandio, Jean-François Eléouët, Marie Galloux, Philippe Durand, Stéphanie Deville-Foillard, Christina Sizun

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 569
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2023, 24 (1), pp.569. ⟨10.3390/ijms24010569⟩

International audience; The interaction between Respiratory Syncytial Virus phosphoprotein P and nucleoprotein N is essential for the formation of the holo RSV polymerase that carries out replication. In vitro screening of antivirals targeting the N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe88f8adbe8f1af16ae1a1d74758cba0
https://doi.org/10.3390/ijms24010569

A condensate-hardening drug blocks RSV replication in vivo

Autor: Jennifer, Risso-Ballester, Marie, Galloux, Jingjing, Cao, Ronan, Le Goffic, Fortune, Hontonnou, Aude, Jobart-Malfait, Aurore, Desquesnes, Svenja M, Sake, Sibylle, Haid, Miaomiao, Du, Xiumei, Zhang, Huanyun, Zhang, Zhaoguo, Wang, Vincent, Rincheval, Youming, Zhang, Thomas, Pietschmann, Jean-François, Eléouët, Marie-Anne, Rameix-Welti, Ralf, Altmeyer

Publikováno v: Nature Reviews. Molecular Cell Biology

The pathogenicity of SARS-CoV-2 and respiratory syncytial virus (RSV) involves mechanisms of liquid–liquid phase separation, which can be explored as targets for new antiviral therapeutics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb0edc58a046b7e5d2dd881c2d687e3f
https://pubmed.ncbi.nlm.nih.gov/34262155

Evaluation of planar bioluminescence imaging and microPET/CT for therapy monitoring in a mouse model of pigmented metastatic melanoma

Autor: Ewa, Pasquereau-Kotula, Benoit, Hosten, Fortune, Hontonnou, Nicolas, Vignal, Florent, Antoni, Jean-Luc, Poyet, Nathalie, Rizzo-Padoin, Laure, Sarda-Mantel

Publikováno v: American journal of nuclear medicine and molecular imaging. 8(6)

Bioluminescence imaging (BLI) is widely used for in-vivo monitoring of anti-cancer therapy in mice. [18F]MEL050 is a Positron Emission Tomography (PET) radiotracer which specifically targets melanin. We evaluated planar BLI and [18F]MEL050-PET/CT for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eddd19dd16e67716a269e3d3e5012769
https://pubmed.ncbi.nlm.nih.gov/30697459