Polygenic heterogeneity in antidepressant treatment and placebo response

Autor: Anne Krogh Nøhr, Annika Forsingdal, Ida Moltke, Oliver D. Howes, Morana Vitezic, Anders Albrechtsen, Maria Dalby

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)

Abstract The genetic architecture of antidepressant response is poorly understood. Polygenic risk scores (PRS), exploration of placebo response and the use of sub-scales might provide insights. Here, we investigate the association between PRSs for re

Externí odkaz: https://doaj.org/article/1ef5143e614e451f83ea81e64b2cbff3

Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?

Autor: Forsingdal, Annika, Jørgensen, Trine Nygaard, Olsen, Line, Werge, Thomas, Didriksen, Michael, Nielsen, Jacob

Publikováno v: In Biological Psychiatry 1 January 2019 85(1):13-24

Increased Prevalence of Rare Copy Number Variants in Treatment-Resistant Psychosis

Autor: Martilias Farrell, Tyler E Dietterich, Matthew K Harner, Lisa M Bruno, Dawn M Filmyer, Rita A Shaughnessy, Maya L Lichtenstein, Rose Mary Xavier, Allison M Britt, Tamara F Biondi, James J Crowley, Gabriel Lázaro-Muñoz, Annika E Forsingdal, Jacob Nielsen, Michael Didriksen, Jonathan S Berg, Jia Wen, Jin Szatkiewicz, Patrick F Sullivan, Richard C Josiassen

Publikováno v: Schizophrenia bulletin.

BackgroundIt remains unknown why ~30% of patients with psychotic disorders fail to respond to treatment. Previous genomic investigations of treatment-resistant psychosis have been inconclusive, but some evidence suggests a possible link between rare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4104393b7c88c478d7e10461b54dd29
https://pubmed.ncbi.nlm.nih.gov/36454006

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A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder

Autor: Anne Krogh Nøhr, Samuel Demharter, Morana Vitezic, Ida Moltke, Raimund Buller, Anders Albrechtsen, Annika Forsingdal, Morten Lindow, Troels Nielsen

Publikováno v: Neuropsychopharmacology
Nøhr, A K, Lindow, M, Forsingdal, A, Demharter, S, Nielsen, T, Buller, R, Moltke, I, Vitezic, M & Albrechtsen, A 2021, ' A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder ', Neuropsychopharmacology, vol. 46, no. 7, pp. 1324-1332 . https://doi.org/10.1038/s41386-021-01002-9

A better understanding of the biological factors underlying antidepressant treatment in patients with major depressive disorder (MDD) is needed. We perform gene expression analyses and explore sources of variability in peripheral blood related to ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d8195f4ef5544a9909a7d7cdecce52
http://europepmc.org/articles/PMC8134553