Výsledky vyhledávání - "Forsch, Ronald A"

Akademický článek

Synthesis of L-2-(N-Pteroylamino )-3-(N -phosphonoacetyl)aminopropanoic Acid as an Analogue of the Putative Phosphorylated Intermediate in the γ-Glutamation of Folic Acid by Folylpolyglutamate Synthetase

Autor: Forsch Ronald, Bader Henry, Rosowsky Andre

Publikováno v: Pteridines, Vol 10, Iss 1, Pp 39-46 (1999)

L-2-(N-Pteroyl)amino-3-(N-phosphonoacetyl)aminopropanoic acid was synthesized as an analogue of the putative y-phosphorylated intermediate in the enzyme-catalyzed γ-glutamation of folic acid by folylpolyglutamate synthetase (FPGS). N-(Benzyloxycarbo

Externí odkaz: https://doaj.org/article/42b90eaf534a4314b75d581dfa087ed7

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Akademický článek

Synthesis of 2,4-Diaminopteridines with Bulky Lipophilic Groups at the 6-Position as Inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mammalian Dihydrofolate Reductase

Autor: Rosowsky Andre, Forsch Ronald A., Queener Sherry F., Bertino Joseph R.

Publikováno v: Pteridines, Vol 8, Iss 3, Pp 173-187 (1997)

Ten previously undescribed 2,4-diamino-6-(2-naphthylamino )methylpteridines with lipophilic chlorine or long-chain alkyl groups on the naphthyl moiety and either hydrogen or a methyl group on N 10 were synthesized from the appropriate 2-naphthylamine

Externí odkaz: https://doaj.org/article/dfe104fb23c7441b9fe4c6d7eeb666b3

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Akademický článek

Synthesis and In Vitro Biological Evaluation of β,γ-Methano Analogues of Methotrexate and Aminopterin

Autor: Rosowsky Andre, Forsch Ronald A., Moran Richard G., Freisheim James H.

Publikováno v: Pteridines, Vol 2, Iss 3, Pp 133-139 (1990)

β,γ-Methano derivatives of methotrexate (MTX) and aminopterin (AMT) were synthesized with the aim of assessing the effect of this side-chain modification on dihydrofolate reductase (OHFR) inhibition, folylpolyglutamate synthetase (FPGS) inhibition,

Externí odkaz: https://doaj.org/article/e7c343891f9d4cd4a2676e6cbd51ac71

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Akademický článek

Synthesis and In Vitro Antitumor Activity of Thiophene Analogues of 5-Chloro-5,8-dideazafolic Acid and 2-Methyl-2-desamino-5-chloro-5,8-dideazafolic Acid

Autor: Forsch, Ronald A., Wright, Joel E., Rosowsky, Andre

Publikováno v: In Bioorganic & Medicinal Chemistry 2002 10(6):2067-2076

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Akademický článek

Synthesis of the Folylpolyglutamate Synthetase Inhibitor Nα-Pteroyl-Lornithine and its Nδ-Benzoyl and Nδ-Hemiphthaloyl Derivatives, and an Improved Synthesis of Nα-( 4-Amino-4-deoxypteroy1)-Nδ-hemiphthaloyl-Lornithine

Autor: Rosowsky Andre, Bader Henry, Forsch Ronald A.

Publikováno v: Pteridines, Vol 1, Iss 2, Pp 91-98 (1989)

N10-Formylpteroic acid may be prepared from folic acid by sequentially heating with formic acid and cleaving the glutamate side chain with carboxypeptidase G1. Condensation of the product with the Nα,O bis( trimethylsilyl) derivative of Nδ-(tert-bu

Externí odkaz: https://doaj.org/article/54b26337014e4914b52767c80bfe32fc

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Carrier- and Receptor-Mediated Transport of Folate Antagonists Targeting Folate-Dependent Enzymes: Correlates of Molecular -Structure and Biological Activity

Autor: Westerhof, G Robbin, Schornagel, Jan H, Kathmann, Ietje, Jackman, Ann L, Rosowsky, Andre, Forsch, Ronald A, Hynes, John B, Boyle, F Thomas, Peters, GJ, Pinedo, HM, Jansen, G

Publikováno v: Westerhof, G R, Schornagel, J H, Kathmann, I, Jackman, A L, Rosowsky, A, Forsch, R A, Hynes, J B, Boyle, F T, Peters, GJ, Pinedo, HM & Jansen, G 1995, ' Carrier-and Receptor-Mediated Transport of Folate Antagonists Targeting Folate-Dependent Enzymes: Correlates of Molecular-Structure and Biological Activity ', Molecular Pharmacology, vol. 48, no. 3, pp. 459-471 .
Molecular Pharmacology, 48(3), 459-471. American Society for Pharmacology and Experimental Therapeutics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::05c0db6312b90c18e81e2fba8512e81c
https://research.vumc.nl/ws/files/10782837/8771