Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Forrest O. Gulden"'
Autor:
Lindsay Liang, Siavash Fazel Darbandi, Sirisha Pochareddy, Forrest O. Gulden, Michael C. Gilson, Brooke K. Sheppard, Atehsa Sahagun, Joon-Yong An, Donna M. Werling, John L. R. Rubenstein, Nenad Sestan, Kevin J. Bender, Stephan J. Sanders
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Genetic variants in the voltage-gated sodium channels SCN1A, SCN2A, SCN3A, and SCN8A are leading causes of epilepsy, developmental delay, and autism spectrum disorder. The mRNA splicing patterns of all four genes vary across devel
Externí odkaz:
https://doaj.org/article/7348d7aab02f4d87839686b6a126df57
Autor:
Donna M. Werling, Sirisha Pochareddy, Jinmyung Choi, Joon-Yong An, Brooke Sheppard, Minshi Peng, Zhen Li, Claudia Dastmalchi, Gabriel Santpere, André M.M. Sousa, Andrew T.N. Tebbenkamp, Navjot Kaur, Forrest O. Gulden, Michael S. Breen, Lindsay Liang, Michael C. Gilson, Xuefang Zhao, Shan Dong, Lambertus Klei, A. Ercument Cicek, Joseph D. Buxbaum, Homa Adle-Biassette, Jean-Leon Thomas, Kimberly A. Aldinger, Diana R. O’Day, Ian A. Glass, Noah A. Zaitlen, Michael E. Talkowski, Kathryn Roeder, Matthew W. State, Bernie Devlin, Stephan J. Sanders, Nenad Sestan
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Gene expression levels vary across developmental stage, cell type, and region in the brain. Genomic variants also contribute to the variation in expression, and some neuropsychiatric disorder loci may exert their effects through this mechani
Externí odkaz:
https://doaj.org/article/659cb161cbb744e39a67fefdafb36d56
Autor:
Marco Onorati, Zhen Li, Fuchen Liu, André M.M. Sousa, Naoki Nakagawa, Mingfeng Li, Maria Teresa Dell’Anno, Forrest O. Gulden, Sirisha Pochareddy, Andrew T.N. Tebbenkamp, Wenqi Han, Mihovil Pletikos, Tianliuyun Gao, Ying Zhu, Candace Bichsel, Luis Varela, Klara Szigeti-Buck, Steven Lisgo, Yalan Zhang, Anze Testen, Xiao-Bing Gao, Jernej Mlakar, Mara Popovic, Marie Flamand, Stephen M. Strittmatter, Leonard K. Kaczmarek, E.S. Anton, Tamas L. Horvath, Brett D. Lindenbach, Nenad Sestan
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2576-2592 (2016)
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroep
Externí odkaz:
https://doaj.org/article/7ed0523b8c024cdea2dcfa2c3cd7c835
Autor:
William B. Dobyns, Georg Seelig, Lynne M. Overman, Forrest O. Gulden, Ian A. Glass, Andrew E. Timms, Ian G. Phelps, Matthew Hirano, Paula Alexandre, Alexander B. Rosenberg, Kathleen J. Millen, Gabriel Santpere, Dan Doherty, Steven Lisgo, Charles M. Roco, Mei Deng, Parthiv Haldipur, Zachary Thomson, Kimberly A. Aldinger, Belen Lorente-Galdos, Diana R. O’Day, Nenad Sestan
Publikováno v:
Nature neuroscience
The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint required to integrate environmental cues with developing motor, cognitive and emotional skills into adulthood. Although mature cerebellar neuroanatomy is well st
Autor:
Nenad Sestan, Donna M. Werling, Brooke Sheppard, Kevin J. Bender, Atehsa Sahagun, Sirisha Pochareddy, Forrest O. Gulden, Siavash Fazel Darbandi, Lindsay Liang, John L.R. Rubenstein, Michael C. Gilson, Stephen Sanders, Joon Yong An
Publikováno v:
Genome medicine, vol 13, iss 1
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
BackgroundGenetic variants in the voltage-gated sodium channelsSCN1A,SCN2A,SCN3A, andSCN8Aare leading causes of epilepsy, developmental delay, and autism spectrum disorder. The mRNA splicing patterns of all four genes vary across development in the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879a6bffbdc8393288db1f7ded8726e9
https://escholarship.org/uc/item/2hk724zk
https://escholarship.org/uc/item/2hk724zk
Autor:
Paula Alexandre, Belen Lorente-Galdos, Diana R. O’Day, Alexander B. Rosenberg, Ian A. Glass, Parthiv Haldipur, Nenad Sestan, Zach Thomson, Charles M. Roco, William B. Dobyns, Kimberly A. Aldinger, Gabriel Santpere, Dan Doherty, Matthew Hirano, Steven Lisgo, Lynne M. Overman, Mei Deng, Andrew E. Timms, Kathleen J. Millen, Forrest O. Gulden, Georg Seelig
Cerebellar development and function require precise regulation of molecular and cellular programs to coordinate motor functions and integrate network signals required for cognition and emotional regulation. However, molecular understanding of human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973ae4c2edc3a36c440ed02aed6d7afb
https://doi.org/10.1101/2020.06.30.174391
https://doi.org/10.1101/2020.06.30.174391
Autor:
Ed S. Lein, Yuka Imamura Kawasawa, Mingfeng Li, Melissa K. Edler, James P. Noonan, Mario Skarica, Marta Melé, Raquel Garcia Perez, Nenad Sestan, Joel E. Kleinman, Mihovil Pletikos, Patrick R. Hof, Kyle A. Meyer, Bernardo Stutz, Forrest O. Gulden, Alexa R. Stephenson, John D. Elsworth, Mary Ann Raghanti, Thomas M. Hyde, Daniel R. Weinberger, Mark Gerstein, Matthew W. State, Akemi Shibata, John J. Ely, Ying Zhu, Tiago Carvalho, Marco Onorati, Chet C. Sherwood, Richard P. Lifton, André M. M. Sousa, Mark Reimers, Fuchen Liu, Shrikant Mane, Tamas L. Horvath, Robert R. Kitchen, Tomas Marques-Bonet, James A. Knowles, Andrew T.N. Tebbenkamp
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya
instname
Recercat. Dipósit de la Recerca de Catalunya
To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-c
Autor:
Michael C. Gilson, Forrest O. Gulden, Zhen Li, Jean-Leon Thomas, Claudia Dastmalchi, Stephen Sanders, Joseph D. Buxbaum, Matthew W. State, Donna M. Werling, Minshi Peng, Navjot Kaur, André M. M. Sousa, Kathryn Roeder, Ian A. Glass, Michael E. Talkowski, Lambertus Klei, Diana R. O’Day, Shan Dong, Lindsay Liang, Xuefang Zhao, Sirisha Pochareddy, Kimberly A. Aldinger, Brooke Sheppard, Bernie Devlin, Gabriel Santpere, A. Ercument Cicek, Homa Adle-Biassette, Joon Yong An, Andrew T.N. Tebbenkamp, Jinmyung Choi, Noah Zaitlen, Michael S. Breen, Nenad Sestan
Publikováno v:
Cell reports, vol 31, iss 1
Cell Reports
Cell Reports, Vol 31, Iss 1, Pp-(2020)
Cell reports
Cell Reports
Cell Reports, Vol 31, Iss 1, Pp-(2020)
Cell reports
SUMMARY Gene expression levels vary across developmental stage, cell type, and region in the brain. Genomic variants also contribute to the variation in expression, and some neuropsychiatric disorder loci may exert their effects through this mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40d256ff3c529add55836204edbc202
https://doi.org/10.1101/585430
https://doi.org/10.1101/585430
Autor:
James T.R. Walters, Ed S. Lein, Donna M. Werling, Paola Giusti-Rodríguez, Mark Gerstein, Shuang Liu, Mihovil Pletikos, Patrick F. Sullivan, Susan M. Sunkin, Fulai Jin, Daniel R. Weinberger, Yuka Imamura Kawasawa, Daifeng Wang, Ming Hu, Michael Conlon O'Donovan, Mingfeng Li, Matthew W. State, Stephen Sanders, Hyo Jung Kang, Jinmyung Choi, Daniel H. Geschwind, Thomas M. Hyde, Michael Hawrylycz, Mark Reimers, Yurae Shin, James A. Knowles, Sirisha Pochareddy, Pat Levitt, Christiaan de Leeuw, Nenad Sestan, Gabriel Santpere, André M. M. Sousa, Danielle Posthuma, Sydney Muchnik, Ying Zhu, Michael John Owen, Oleg V. Evgrafov, Hyejung Won, PsychENCODE Developmental Subgroup, Xuming Xu, Forrest O. Gulden, Zhen Li, Yun Li, Robert R. Kitchen, Antonio F. Pardiñas, Joel E. Kleinman, Belen Lorente-Galdos
Publikováno v:
Science (New York, N.Y.), vol 362, iss 6420
Science, 362(6420):1264, 1-15. American Association for the Advancement of Science
Li, M, Santpere, G, Kawasawa, Y I, Evgrafov, O V, Gulden, F O, Pochareddy, S, Sunkin, S M, Li, Z, Shin, Y, Zhu, Y, Sousa, A M M, Werling, D M, Kitchen, R R, Kang, H J, Pletikos, M, Choi, J, Muchnik, S, Xu, X, Wang, D, Lorente-Galdos, B, Liu, S, Giusti-Rodríguez, P, Won, H, De Leeuw, C A, Pardiñas, A F, Hu, M, Jin, F, Li, Y, Owen, M J, O'Donovan, M C, Walters, J T R, Posthuma, D, Levitt, P, Weinberger, D R, Hyde, T M, Kleinman, J E, Geschwind, D H, Hawrylycz, M J, State, M W, Sanders, S J, Sullivan, P F, Gerstein, M B, Lein, E S, Knowles, J A & Sestan, N 2018, ' Integrative functional genomic analysis of human brain development and neuropsychiatric risks ', Science, vol. 362, no. 6420, 1264, pp. 1-15 . https://doi.org/10.1126/science.aat7615
Science, 362(6420):1264, 1-15. American Association for the Advancement of Science
Li, M, Santpere, G, Kawasawa, Y I, Evgrafov, O V, Gulden, F O, Pochareddy, S, Sunkin, S M, Li, Z, Shin, Y, Zhu, Y, Sousa, A M M, Werling, D M, Kitchen, R R, Kang, H J, Pletikos, M, Choi, J, Muchnik, S, Xu, X, Wang, D, Lorente-Galdos, B, Liu, S, Giusti-Rodríguez, P, Won, H, De Leeuw, C A, Pardiñas, A F, Hu, M, Jin, F, Li, Y, Owen, M J, O'Donovan, M C, Walters, J T R, Posthuma, D, Levitt, P, Weinberger, D R, Hyde, T M, Kleinman, J E, Geschwind, D H, Hawrylycz, M J, State, M W, Sanders, S J, Sullivan, P F, Gerstein, M B, Lein, E S, Knowles, J A & Sestan, N 2018, ' Integrative functional genomic analysis of human brain development and neuropsychiatric risks ', Science, vol. 362, no. 6420, 1264, pp. 1-15 . https://doi.org/10.1126/science.aat7615
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes us uniquely human. The development of the brain is a highly complex process, and this process is reliant on precise regulation of molecular and cellular events grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d2f55db6e1ad43aca6bf9fa87db245
https://escholarship.org/uc/item/2gt1b22t
https://escholarship.org/uc/item/2gt1b22t
Autor:
Zhuo Li, Forrest O. Gulden, Sirisha Pochareddy, Begoña Ballester-Lurbe, Alain Chédotal, M. Pilar Madrigal, Navjot Kaur, Xuming Xu, Sungbo Shim, José Terrado, Wenqi Han, Xiaojun Xing, Nenad Sestan, Juan Antonio Moreno-Bravo, Yutaka Takeo, Kangrong Lu, Ignacio Pérez-Roger, Yuka Imamura Kawasawa, Mingfeng Li, Zhen Li, Anthony J. Koleske
Publikováno v:
Neuron
Neural stem cells directly or indirectly generate all neurons and macroglial cells and guide migrating neurons by using a palisade-like scaffold made of their radial fibers. Here, we describe an unexpected role for the radial fiber scaffold in direct