Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides.

Autor: Pandi A; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany. amir.pandi@mpi-marburg.mpg.de., Adam D; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.; Bundeswehr Institute of Microbiology, Munich, Germany., Zare A; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Trinh VT; Department of Chemistry, Philipps-University Marburg, Marburg, Germany., Schaefer SL; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany., Burt M; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Klabunde B; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Bobkova E; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Kushwaha M; Université Paris-Saclay, INRAe, AgroParisTech, Micalis Institute, Jouy-en-Josas, France., Foroughijabbari Y; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Braun P; Bundeswehr Institute of Microbiology, Munich, Germany.; German Center for Infection Research (DZIF), Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Immunology, Infection and Pandemic Research, Munich, Germany., Spahn C; Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany., Preußer C; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Philipps-University Marburg, Marburg, Germany.; Core Facility Extracellular Vesicles, Center for Tumor Biology and Immunology, Philipps-University of Marburg, Marburg, Germany., Pogge von Strandmann E; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Philipps-University Marburg, Marburg, Germany.; Core Facility Extracellular Vesicles, Center for Tumor Biology and Immunology, Philipps-University of Marburg, Marburg, Germany., Bode HB; Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.; Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany.; Department of Chemistry, Chemical Biology, Philipps-University Marburg, Marburg, Germany.; Senckenberg Gesellschaft für Naturforschung, Frankfurt, Germany.; SYNMIKRO Center of Synthetic Microbiology, Marburg, Germany., von Buttlar H; Bundeswehr Institute of Microbiology, Munich, Germany.; German Center for Infection Research (DZIF), Munich, Germany., Bertrams W; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Jung AL; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; Core Facility Flow Cytometry - Bacterial Vesicles, Philipps-University Marburg, Marburg, Germany., Abendroth F; Department of Chemistry, Philipps-University Marburg, Marburg, Germany., Schmeck B; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; SYNMIKRO Center of Synthetic Microbiology, Marburg, Germany.; Core Facility Flow Cytometry - Bacterial Vesicles, Philipps-University Marburg, Marburg, Germany.; Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Marburg, Philipps-University Marburg, Marburg, Germany.; Institute for Lung Health (ILH), Giessen, Germany.; Member of the German Center for Infectious Disease Research (DZIF), Marburg, Germany., Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.; Institute for Biophysics, Goethe University Frankfurt, Frankfurt am Main, Germany., Vázquez O; Department of Chemistry, Philipps-University Marburg, Marburg, Germany.; SYNMIKRO Center of Synthetic Microbiology, Marburg, Germany., Erb TJ; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany. toerb@mpi-marburg.mpg.de.; SYNMIKRO Center of Synthetic Microbiology, Marburg, Germany. toerb@mpi-marburg.mpg.de.

Publikováno v: Nature communications [Nat Commun] 2023 Nov 08; Vol. 14 (1), pp. 7197. Date of Electronic Publication: 2023 Nov 08.

Cell-Free Systems: Ideal Platforms for Accelerating the Discovery and Production of Peptide-Based Antibiotics.

Autor: Park, Hyeongwoo¹ (AUTHOR) hwdream2016@postech.ac.kr, Jin, Haneul² (AUTHOR) jinhn@postech.ac.kr, Kim, Dayeong² (AUTHOR) dayeongk@postech.ac.kr, Lee, Joongoo^1,2 (AUTHOR) jgoolee@postech.ac.kr

Publikováno v: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p9109. 27p.

An enhanced genetic algorithm solution for itinerary recommendation considering various constraints.

Autor: Şehab, Muhammed, Turan, Metin

Publikováno v: PeerJ Computer Science; Oct2024, p1-41, 41p

The Century-Long Journey of Peptide-Based Drugs.

Autor: Almeida, José R.

Publikováno v: Antibiotics (2079-6382); Mar2024, Vol. 13 Issue 3, p196, 5p

Computational tools for plant genomics and breeding.

Autor: Wang H; State Key Laboratory of Maize Bio-breeding, Frontiers Science Center for Molecular Design Breeding, Joint International Research Laboratory of Crop Molecular Breeding, National Maize Improvement Center, College of Agronomy and Biotechnology, China Agricultural University, Beijing, 100193, China. wanghai@cau.edu.cn.; Sanya Institute of China Agricultural University, Sanya, 572025, China. wanghai@cau.edu.cn.; Hainan Yazhou Bay Seed Laboratory, Sanya, 572025, China. wanghai@cau.edu.cn., Chen M; State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of the State Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing, 100091, China., Wei X; Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China., Xia R; College of Horticulture, South China Agricultural University, Guangzhou, 510640, China., Pei D; State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of the State Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing, 100091, China., Huang X; Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China., Han B; National Center for Gene Research, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 200233, China.

Publikováno v: Science China. Life sciences [Sci China Life Sci] 2024 Aug; Vol. 67 (8), pp. 1579-1590. Date of Electronic Publication: 2024 Apr 23.