The KAT module of the SAGA complex maintains the oncogenic gene expression program in MYCN- amplified neuroblastoma.

Autor: Malone CF; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Mabe NW; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Forman AB; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Engel KL; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chen YC; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Soeung M; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Salhotra S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Basanthakumar A; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Liu B; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dent SYR; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The Center for Cancer Epigenetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA.

Publikováno v: Science advances [Sci Adv] 2024 May 31; Vol. 10 (22), pp. eadm9449. Date of Electronic Publication: 2024 May 31.

Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer.

Autor: Malone CF; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Dharia NV; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts., Kugener G; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Forman AB; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Rothberg MV; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Abdusamad M; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Gonzalez A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Kuljanin M; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Robichaud AL; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Conway AS; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Dempster JM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Paolella BR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Dumont N; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Hovestadt V; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts., Mancias JD; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Younger ST; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Root DE; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Golub TR; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts., Vazquez F; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Kimberly_stegmaier@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.

Publikováno v: Cancer discovery [Cancer Discov] 2021 Sep; Vol. 11 (9), pp. 2282-2299. Date of Electronic Publication: 2021 Apr 21.

A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus.

Autor: Valeski JE; IMMCO Diagnostics Inc., Buffalo, NY 14223., Kumar V, Forman AB, Beutner EH, Chorzelski TP

Publikováno v: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 1992 Aug; Vol. 27 (2 Pt 1), pp. 194-8.

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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells.

Autor: Terasaki T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Semba Y; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.; Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Sasaki K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan., Imanaga H; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan., Setoguchi K; Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Yamauchi T; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Hirabayashi S; Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Nakao F; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan., Akahane K; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan., Inukai T; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan., Sanda T; Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Akashi K; Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.; Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan., Maeda T; Division of Precision Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan. maeda.takahiro.294@m.kyushu-u.ac.jp.

Publikováno v: Leukemia [Leukemia] 2024 Sep; Vol. 38 (9), pp. 1918-1928. Date of Electronic Publication: 2024 Jul 11.