Výsledky vyhledávání - "Fork head domain"

Molecular cloning and expression analysis of Foxp3 from Nile tilapia

Autor: Wenchuang Qi, Minghui Li, Deshou Wang, Jing Wei, Xiaoping Zhang, Lintian Yu, Lina Sun, Linyan Zhou

Publikováno v: Veterinary Immunology and Immunopathology. 155:48-56

Foxp3 is a crucial transcription factor for the development and function of CD4(+)CD25(+) regulatory T cells (Tr) which play a key role in preventing autoimmune diseases and maintaining maternal-fetal tolerance in mammals. However, the knowledge of F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3f64886d6553a9ed08d72016ff64e3
https://doi.org/10.1016/j.vetimm.2013.06.004

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A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes

Autor: John Lally, Antony M. Carr, Andrew J. Fadden, Neil Q. McDonald, Richard Harris, Stephanie A. Schalbetter, Maureen Bowles

Publikováno v: Nucleic Acids Research

The MUS81-EME1 endonuclease maintains metazoan genomic integrity by cleaving branched DNA structures that arise during the resolution of recombination intermediates. In humans, MUS81 also forms a poorly characterized complex with EME2. Here, we ident

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https://doi.org/10.1093/nar/gkt760

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The Fox genes of Branchiostoma floridae

Autor: Francoise Mazet, Kuo-Chen Jung, Song-Wei Huang, Yen-Ta Chen, Jr-Kai Yu, Sebastian M. Shimeld

Publikováno v: Development Genes and Evolution. 218:629-638

The Fox genes are united by encoding a fork head domain, a deoxyribonucleic acid (DNA)-binding domain of the winged-helix type that marks these genes as encoding transcription factors. Vertebrate Fox genes are classified into 23 subclasses named from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300ef835048b10c0e16fc6650312e66b
https://doi.org/10.1007/s00427-008-0229-9

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NMR Dynamics Distinguish Between Hard and Soft Hydrophobic Cores in the DNA-binding Domain of PhoB and Demonstrate Different Roles of the Cores in Binding to DNA

Autor: Yoshifumi Nishimura, Kozo Makino, Hideyasu Okamura

Publikováno v: Journal of Molecular Biology. 367:1093-1117

The transcription factor PhoB contains an N-terminal regulatory domain and a C-terminal DNA-binding/transactivation domain. The DNA-binding/transactivation domain alone can bind specifically to DNA and consequently activate transcription. It consists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606646d8b00b7d0e4dcae03d490e6133
https://doi.org/10.1016/j.jmb.2007.01.052

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Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance*

Autor: Asami Hishiki, Toshiyuki Shimizu, Kodai Hara, Mamoru Sato, Hideshi Yokoyama, Yuzu Ikegaya, Hiroshi Hashimoto

HLTF (helicase-like transcription factor) is a yeast RAD5 homolog found in mammals. HLTF has E3 ubiquitin ligase and DNA helicase activities, and plays a pivotal role in the template-switching pathway of DNA damage tolerance. HLTF has an N-terminal d

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https://europepmc.org/articles/PMC4505575/

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Molecular Architecture of a Eukaryotic DNA Replication Terminus-Terminator Protein Complex

Autor: Gregor Krings, Deepak Bastia

Publikováno v: Molecular and Cellular Biology. 26:8061-8074

DNA replication forks pause at programmed fork barriers within nontranscribed regions of the ribosomal DNA (rDNA) genes of many eukaryotes to coordinate and regulate replication, transcription, and recombination. The mechanism of eukaryotic fork arre

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https://doi.org/10.1128/mcb.01102-06

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Solution Structure and DNA-binding Mode of the Matrix Attachment Region-binding Domain of the Transcription Factor SATB1 That Regulates the T-cell Maturation

Autor: Kazuhiko Yamasaki, Hiroshi Yamaguchi, Masaru Tateno

Publikováno v: Journal of Biological Chemistry. 281:5319-5327

SATB1 is a transcriptional regulator controlling the gene expression that is essential in the maturation of the immune T-cell. SATB1 binds to the nuclear matrix attachment regions of DNA, where it recruits histone deacetylase and represses transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dc461261e842f8809515af3c5b9a82
https://doi.org/10.1074/jbc.m510933200

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The β3 tubulin gene is a direct target of bagpipe and biniou in the visceral mesoderm of Drosophila

Autor: Stéphane Zaffran, Manfred Frasch

Publikováno v: Mechanisms of Development. 114(1-2):85-93

Previous studies have identified the NK homeobox gene bagpipe and the FoxF fork head domain gene biniou as essential regulators of visceral mesoderm development in Drosophila. Here we present additional genetic and molecular information on the functi

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